[{"Gene":"ADCY4","Gene synonym":["AC4"],"Ensembl":"ENSG00000129467","Gene description":"Adenylate cyclase 4","Uniprot":["Q8NFM4"],"Chromosome":"14","Position":"24318349-24335093","Protein class":["Enzymes","Metabolic proteins","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["cAMP biosynthesis"],"Molecular function":["Lyase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"6","RNA single cell type specific nTPM":{"Adipocytes":"83.5","Endothelial cells":"74.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"9","RNA blood cell specific nTPM":{"basophil":"2.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"granulocytes":"2.9"},"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Kidney - Endothelial cells","Liver - Vascular Endothelial cells","Pancreas - Endothelial cells","Prostate - Endothelial cells","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Testis - Endothelial cells","Thyroid - Endothelial cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB005070","HPA048344"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 41: Basophils - Cellular respiration","Tissue expression cluster":"Cluster 82: Adipose tissue - ECM organization","Cell line expression cluster":"Cluster 20: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB005070":"AB_2273639","HPA048344":"AB_2680366"},"Pathology prognostics - Breast cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.59e-2"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.34e-1"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.47e-4"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"favorable","is_prognostic":true,"p_val":"8.20e-4"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.06e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.82e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.75e-4"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.58e-2"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.51e-2"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.88e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.77e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.87e-2"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"7.01e-4"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.02e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.88e-2"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.57e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.47e-2"}},{"Gene":"DIPK2B","Gene synonym":["CXorf36","DIA1R","FLJ14103"],"Ensembl":"ENSG00000147113","Gene description":"Divergent protein kinase domain 2B","Uniprot":["Q9H7Y0"],"Chromosome":"X","Position":"45148373-45200901","Protein class":["Disease related genes","Predicted secreted proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Autism","Autism spectrum disorder"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Adipocytes":"173.4","Endothelial cells":"135.9"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Liver - Vascular Endothelial cells","Pancreas - Endothelial cells","Prostate - Endothelial cells","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Testis - Endothelial cells","Thyroid - Endothelial cells"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA002806"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted - unknown location","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"940000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Adipose tissue - ECM organization","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA002806":"AB_1078595"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.12e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.32e-2"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.51e-3"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.05e-1"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.65e-2"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.07e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.30e-2"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.61e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.50e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.39e-1"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.06e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.32e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.75e-3"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.79e-3"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.98e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.47e-2"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.11e-2"}},{"Gene":"ESAM","Gene synonym":["W117m"],"Ensembl":"ENSG00000149564","Gene description":"Endothelial cell adhesion molecule","Uniprot":["Q96AP7"],"Chromosome":"11","Position":"124752583-124762290","Protein class":["Plasma proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Adipocytes":"385.2","Endothelial cells":"271.5","Sertoli cells":"63.6","Smooth muscle cells":"101.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"8.2","naive B-cell":"7.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"9","RNA blood lineage specific nTPM":{"B-cells":"7.5","granulocytes":"8.2","T-cells":"2.2"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Leukemia":"15.7"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Liver - Vascular Endothelial cells","Lung - Endothelial cells","Pancreas - Endothelial cells","Prostate - Endothelial cells","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Stomach - Endothelial cells","Testis - Endothelial cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA056293","HPA072563"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Cell Junctions","Cytosol"],"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"82000000","Blood expression cluster":"Cluster 34: Basophils - Unknown function","Tissue expression cluster":"Cluster 82: Adipose tissue - ECM organization","Cell line expression cluster":"Cluster 32: Myeloid leukemia - Oxygen transport","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":["Cell Junctions"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA056293":"AB_2683089","HPA072563":null},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.52e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.03e-1"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.05e-2"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.56e-1"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.41e-2"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.49e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.61e-1"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.05e-2"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.99e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.08e-1"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.60e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.54e-1"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.10e-2"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.29e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.06e-2"}},{"Gene":"GIMAP8","Gene synonym":["DKFZp667I133","hIAN6","IAN9"],"Ensembl":"ENSG00000171115","Gene description":"GTPase, IMAP family member 8","Uniprot":["Q8ND71"],"Chromosome":"7","Position":"150450630-150479393","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"lymphoid tissue":"40.6"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Adipocytes":"65.2","Endothelial cells":"82.1","Kupffer cells":"66.5","Macrophages":"30.7","Microglial cells":"31.9","monocytes":"35.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"6","RNA cell line specific nTPM":{"Leukemia":"1.5","lymphoma":"2.3","Myeloma":"1.2"},"RNA tissue cell type enrichment":["Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Lung - Endothelial cells","Prostate - Endothelial cells","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Testis - Endothelial cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA014474","HPA017765"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 51: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 16: Immune cells - Immune response","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA014474":"AB_1849685","HPA017765":"AB_1849683"},"Pathology prognostics - Breast cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.86e-2"},"Pathology prognostics - Cervical cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.87e-3"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.04e-1"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.42e-3"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.11e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.09e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.07e-3"},"Pathology prognostics - Lung cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.32e-2"},"Pathology prognostics - Melanoma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.58e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.07e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.26e-3"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.15e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.04e-3"},"Pathology prognostics - Stomach cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.01e-1"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"8.47e-4"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.85e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.31e-1"}},{"Gene":"ITGA5","Gene synonym":["CD49e","FNRA"],"Ensembl":"ENSG00000161638","Gene description":"Integrin subunit alpha 5","Uniprot":["P08648"],"Chromosome":"12","Position":"54395261-54419266","Protein class":["Cancer-related genes","CD markers","Plasma proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion","Host-virus interaction"],"Molecular function":["Host cell receptor for virus entry","Integrin","Receptor"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"398.8","smooth muscle":"361.9","urinary bladder":"386.5"},"RNA single cell type specificity":"Cell type enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Extravillous trophoblasts":"447.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"neutrophil":"89.1"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Kidney - Endothelial cells","Liver - Vascular Endothelial cells","Prostate - Smooth muscle cells","Testis - Endothelial cells"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in many","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"basal ganglia":"10.4"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA002642","CAB009008"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"26000000","Blood expression cluster":"Cluster 8: Neutrophils - Inflammatory response","Tissue expression cluster":"Cluster 12: Smooth muscle tissue - Mixed function","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 54: Extravillous trophoblasts - Unknown function","Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB009008":"AB_647474","HPA002642":"AB_1078469"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.51e-3"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"4.07e-6"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"8.43e-4"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.58e-1"},"Pathology prognostics - Glioma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.51e-3"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"2.91e-4"},"Pathology prognostics - Liver cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"2.23e-5"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"2.44e-4"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.76e-2"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.19e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.99e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.28e-2"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"1.32e-8"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.11e-3"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.35e-2"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"8.89e-4"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.18e-3"}},{"Gene":"MCF2L","Gene synonym":["ARHGEF14","DBS","KIAA0362","OST"],"Ensembl":"ENSG00000126217","Gene description":"MCF.2 cell line derived transforming sequence like","Uniprot":["O15068"],"Chromosome":"13","Position":"112894378-113099742","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Guanine-nucleotide releasing factor"],"Disease involvement":["Proto-oncogene"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"brain":"134.5"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Adipocytes":"127.9","Bipolar cells":"62.9","Cone photoreceptor cells":"98.2","Endothelial cells":"66.6","Intestinal goblet cells":"66.0","Microglial cells":"90.3","Oligodendrocytes":"70.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"skin cancer":"33.2"},"RNA tissue cell type enrichment":["Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Testis - Endothelial cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: B-cells - Adaptive immune response","Tissue expression cluster":"Cluster 69: Cerebellum - 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Lung cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.02e-2"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.94e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.11e-1"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":true,"p_val":"4.36e-5"},"Pathology prognostics - Prostate cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.17e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"favorable","is_prognostic":true,"p_val":"9.14e-6"},"Pathology prognostics - Stomach cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.04e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.28e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.24e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"favorable","is_prognostic":true,"p_val":"2.63e-5"}},{"Gene":"MMRN2","Gene synonym":["EMILIN3","EndoGlyx-1","FLJ13465"],"Ensembl":"ENSG00000173269","Gene description":"Multimerin 2","Uniprot":["Q9H8L6"],"Chromosome":"10","Position":"86935540-86969481","Protein class":["Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Angiogenesis"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"7","RNA single cell type specific nTPM":{"Adipocytes":"220.5","Endothelial cells":"134.8"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"84000000","Blood expression cluster":"Cluster 16: MAIT-cells - Unknown function","Tissue expression cluster":"Cluster 82: Adipose tissue - ECM organization","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"HPA020741":"AB_1848154"},"Pathology prognostics - Breast cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.17e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.87e-2"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.67e-3"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.30e-1"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.73e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.08e-2"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.75e-3"},"Pathology prognostics - Lung cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.43e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.09e-2"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.11e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.81e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.34e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.17e-3"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.54e-3"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.25e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.44e-2"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.66e-1"}},{"Gene":"NPR1","Gene synonym":["ANPa","ANPRA","GUCY2A","NPRA"],"Ensembl":"ENSG00000169418","Gene description":"Natriuretic peptide receptor 1","Uniprot":["P16066"],"Chromosome":"1","Position":"153678688-153693992","Protein class":["Enzymes","FDA approved drug targets","Metabolic proteins","Predicted membrane proteins","Transporters"],"Biological process":["cGMP biosynthesis"],"Molecular function":["Lyase","Receptor","Vasoactive"],"Disease involvement":["FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"adipose tissue":"67.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Adipocytes":"92.4","Alveolar cells type 2":"24.5","Endothelial cells":"55.0","Fibroblasts":"35.0"},"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in all","RNA cancer specificity score":"4","RNA cancer specific FPKM":{"ovarian cancer":"39.2","renal cancer":"12.8"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"cervical cancer":"9.2","ovarian cancer":"8.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipocytes (Subcutaneous)","Adipose visceral - Adipocytes (Visceral)","Breast - Adipocytes (Breast)","Liver - Vascular Endothelial cells","Prostate - Endothelial cells","Testis - Endothelial cells"],"RNA mouse brain regional specificity":"Region enriched","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":"5","RNA mouse brain regional specific nTPM":{"olfactory bulb":"18.7"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in many","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA031087"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nucleoli","Plasma membrane"],"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Adipose tissue - ECM organization","Cell line expression cluster":"Cluster 59: Fibroblasts - Metabolism","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":["Nucleoli"],"Subcellular additional location":["Nucleoplasm","Plasma membrane"],"Antibody RRID":{"HPA031087":"AB_10601975"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.54e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.03e-3"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.31e-2"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"3.97e-4"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.55e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.60e-2"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.54e-2"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.03e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.46e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.27e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":true,"p_val":"2.49e-4"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.27e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.69e-2"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.16e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.09e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.06e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.74e-2"}},{"Gene":"PECAM1","Gene synonym":["CD31"],"Ensembl":"ENSG00000261371","Gene description":"Platelet and endothelial cell adhesion molecule 1","Uniprot":["P16284"],"Chromosome":"17","Position":"64319415-64413776","Protein class":["Cancer-related genes","Candidate cardiovascular disease genes","CD markers","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Cell adhesion","Phagocytosis"],"Molecular function":null,"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"placenta":"455.1"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Adipocytes":"691.0","Endothelial cells":"633.9","monocytes":"238.5"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"non-classical monocyte":"702.3"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"4","RNA cell line specific nTPM":{"Leukemia":"40.8"},"RNA tissue cell type enrichment":["Adipose subcutaneous - 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Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"110000000","Blood expression cluster":"Cluster 51: Monocytes - Innate immune response","Tissue expression cluster":"Cluster 28: Placenta - Pregnancy","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":["Plasma membrane"],"Subcellular additional location":["Nucleoli"],"Antibody RRID":{"HPA004690":"AB_1078462","HPA004871":null},"Pathology prognostics - Breast cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.79e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.14e-1"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.79e-2"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.76e-1"},"Pathology prognostics - Glioma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.34e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.42e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.84e-1"},"Pathology prognostics - Lung cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.37e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.57e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.25e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.53e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.68e-2"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"8.98e-5"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.72e-3"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.57e-2"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.56e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.16e-2"}},{"Gene":"S1PR1","Gene synonym":["CD363","D1S3362","edg-1","EDG1"],"Ensembl":"ENSG00000170989","Gene description":"Sphingosine-1-phosphate receptor 1","Uniprot":["P21453"],"Chromosome":"1","Position":"101236865-101243713","Protein class":["Cancer-related genes","CD markers","FDA approved drug targets","G-protein coupled receptors","Predicted membrane proteins","Transporters"],"Biological process":["Angiogenesis","Chemotaxis"],"Molecular function":["G-protein coupled receptor","Receptor","Transducer"],"Disease involvement":["Cancer-related genes","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Adipocytes":"261.4","Endothelial cells":"153.5","NK-cells":"58.4"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"basophil":"1248.4"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"21.9"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Lung - Endothelial cells","Pancreas - Endothelial cells","Prostate - Endothelial cells","Skeletal muscle - Endothelial cells","Skin - Endothelial cells","Stomach - Endothelial cells","Testis - Endothelial cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB010104","HPA075568"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Vesicles"],"Secretome location":null,"CCD Protein":"No","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 38: Basophils - Unknown function","Tissue expression cluster":"Cluster 57: Non-specific - Angiogenesis","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":["Vesicles"],"Subcellular additional location":null,"Antibody RRID":{"CAB010104":"AB_2238920","HPA075568":"AB_2686758"},"Pathology prognostics - Breast cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.41e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.35e-2"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.46e-2"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.61e-1"},"Pathology prognostics - Glioma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.78e-2"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.49e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.34e-3"},"Pathology prognostics - Lung cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.99e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.36e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.12e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.34e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.23e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.82e-3"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.54e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.04e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.64e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"8.78e-4"}},{"Gene":"TIE1","Gene synonym":["JTK14","TIE"],"Ensembl":"ENSG00000066056","Gene description":"Tyrosine kinase with immunoglobulin like and EGF like domains 1","Uniprot":["P35590"],"Chromosome":"1","Position":"43300982-43323108","Protein class":["Cancer-related genes","Enzymes","Plasma proteins","Predicted intracellular proteins","Predicted membrane proteins"],"Biological process":["Angiogenesis"],"Molecular function":["Kinase","Receptor","Transferase","Tyrosine-protein kinase"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"4","RNA single cell type specific nTPM":{"Adipocytes":"126.1","Endothelial cells":"108.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Group enriched","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":"24","RNA blood cell specific nTPM":{"basophil":"2.1","NK-cell":"2.5"},"RNA blood lineage specificity":"Group enriched","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":"24","RNA blood lineage specific nTPM":{"granulocytes":"2.1","NK-cells":"2.5"},"RNA cell line specificity":"Group enriched","RNA cell line distribution":"Detected in many","RNA cell line specificity score":"5","RNA cell line specific nTPM":{"Leukemia":"12.2","ovarian cancer":"22.4","Sarcoma":"24.1","thyroid cancer":"28.1"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Heart muscle - Endothelial cells","Kidney - Endothelial cells","Liver - Vascular Endothelial cells","Pancreas - Endothelial cells","Prostate - Endothelial cells","Skin - Endothelial cells","Testis - Endothelial cells","Thyroid - Endothelial cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"87000000","Blood expression cluster":"Cluster 41: Basophils - Cellular respiration","Tissue expression cluster":"Cluster 82: Adipose tissue - ECM organization","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.88e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.26e-1"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.60e-3"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.01e-1"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.91e-2"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.53e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.19e-2"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.83e-2"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.02e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.34e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.91e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.25e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.17e-3"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.16e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.89e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.29e-2"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.35e-2"}},{"Gene":"VWF","Gene synonym":["F8VWF"],"Ensembl":"ENSG00000110799","Gene description":"Von Willebrand factor","Uniprot":["P04275"],"Chromosome":"12","Position":"5948877-6124770","Protein class":["Cancer-related genes","Candidate cardiovascular disease genes","Disease related genes","FDA approved drug targets","Human disease related genes","Plasma proteins","Predicted secreted proteins"],"Biological process":["Blood coagulation","Cell adhesion","Hemostasis"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","FDA approved drug targets","von Willebrand disease"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":"11","RNA single cell type specific nTPM":{"Adipocytes":"930.0","Endothelial cells":"826.7"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":{"renal cancer":"76.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Endothelial cells","Adipose visceral - Endothelial cells","Breast - Endothelial cells","Colon - Endothelial cells","Prostate - Endothelial cells","Skeletal muscle - Endothelial cells","Stomach - Endothelial cells","Testis - Endothelial cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB001694","HPA001815","HPA002082","CAB072874","CAB072875"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Secreted to blood","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":28300000000,"Blood concentration - Conc. blood MS [pg\/L]":"5600000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Adipose tissue - ECM organization","Cell line expression cluster":"Cluster 3: HUVEC & TIME - Signal transduction","Single cell expression cluster":"Cluster 66: Endothelial cells - Angiogenesis","Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"CAB001694":null,"CAB072874":"AB_2665726","CAB072875":"AB_2665727","HPA001815":"AB_611880","HPA002082":"AB_1080575"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.66e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.11e-1"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.46e-2"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.27e-1"},"Pathology prognostics - Glioma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.43e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.91e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.09e-2"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.63e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.63e-2"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.92e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"4.69e-1"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.12e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.98e-2"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"2.31e-4"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.55e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.12e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.73e-3"}}]