Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific nTPM"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific nTPM"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific FPKM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific nTPM"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific nTPM"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific nTPM"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific nTPM"	"RNA tissue cell type enrichment"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific nTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific nTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Blood expression cluster"	"Tissue expression cluster"	"Cell line expression cluster"	"Single cell expression cluster"	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Pathology prognostics - Breast cancer"	"Pathology prognostics - Cervical cancer"	"Pathology prognostics - Colorectal cancer"	"Pathology prognostics - Endometrial cancer"	"Pathology prognostics - Glioma"	"Pathology prognostics - Head and neck cancer"	"Pathology prognostics - Liver cancer"	"Pathology prognostics - Lung cancer"	"Pathology prognostics - Melanoma"	"Pathology prognostics - Ovarian cancer"	"Pathology prognostics - Pancreatic cancer"	"Pathology prognostics - Prostate cancer"	"Pathology prognostics - Renal cancer"	"Pathology prognostics - Stomach cancer"	"Pathology prognostics - Testis cancer"	"Pathology prognostics - Thyroid cancer"	"Pathology prognostics - Urothelial cancer"
ALDH1L1	"10-fTHF, FDH, FTHFD"	ENSG00000144908	"Aldehyde dehydrogenase 1 family member L1"	O75891	3	126103562-126197994	"Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins"	"One-carbon metabolism"	Oxidoreductase		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"liver: 369.7"	"Cell type enhanced"	"Detected in many"		"Astrocytes: 89.8;Hepatocytes: 550.1;Proximal tubular cells: 166.9;Serous glandular cells: 92.2"	"Cancer enriched"	"Detected in many"	4	"liver cancer: 40.4"	"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enhanced"	"Detected in many"		"Bladder cancer: 18.2"	"Adipose subcutaneous - Adipocytes (Subcutaneous), Adipose visceral - Adipocytes (Visceral), Breast - Adipocytes (Breast), Heart muscle - Cardiomyocytes, Kidney - Proximal tubular cells, Kidney - Proximal tubular cells, Liver - Hepatocytes"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA036900, HPA050139"	Enhanced	Supported	Supported	Cytosol		No	No		3000000		"Cluster 15: Liver - Metabolism"	"Cluster 60: Keratinocytes - Epithelial cell function"	"Cluster 13: Hepatocytes - Oxidoreductase activity"	Cytosol		"HPA036900: AB_10672273, HPA050139: AB_2681031"	"unprognostic (5.93e-2)"	"unprognostic (1.22e-1)"	"unprognostic (9.12e-2)"	"unprognostic (2.68e-1)"	"unprognostic (1.10e-1)"	"unprognostic (1.10e-1)"	"unprognostic (7.12e-2)"	"unprognostic (1.29e-1)"	"unprognostic (3.05e-2)"	"unprognostic (4.73e-2)"	"unprognostic (3.05e-3)"	"unprognostic (8.40e-2)"	"prognostic favorable (2.42e-8)"	"unprognostic (3.60e-1)"	"unprognostic (1.47e-1)"	"unprognostic (7.03e-3)"	"unprognostic (7.93e-2)"
ALDH1L2	"FLJ38508, mtFDH"	ENSG00000136010	"Aldehyde dehydrogenase 1 family member L2"	Q3SY69	12	105019784-105107643	"Enzymes, Metabolic proteins, Predicted intracellular proteins"	"One-carbon metabolism"	Oxidoreductase		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Group enriched"	"Detected in many"	5	"pancreas: 40.7;salivary gland: 13.0"	"Cell type enhanced"	"Detected in many"		"Early spermatids: 40.2;Excitatory neurons: 22.7;Inhibitory neurons: 23.5;Oligodendrocyte precursor cells: 24.1;Plasma cells: 23.4;Serous glandular cells: 33.7"	"Low cancer specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enhanced"	"Detected in many"		"Myeloma: 38.1"		"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA039481, HPA059282"	Approved		Enhanced	Mitochondria		No	No				"Cluster 25: Pancreas - Digestion"	"Cluster 20: Connective tissue cells - ECM organization"	"Cluster 21: Serous glandular cells - Salivary secretion"	Mitochondria		"HPA039481: AB_10795465, HPA059282: AB_2732633"	"unprognostic (5.99e-2)"	"unprognostic (1.42e-1)"	"unprognostic (1.10e-1)"	"unprognostic (1.36e-3)"	"unprognostic (1.76e-1)"	"unprognostic (8.86e-2)"	"unprognostic (1.75e-1)"	"unprognostic (2.92e-1)"	"unprognostic (5.74e-2)"	"unprognostic (1.51e-1)"	"unprognostic (1.01e-1)"	"unprognostic (1.61e-1)"	"unprognostic (8.19e-8)"	"unprognostic (3.21e-3)"	"unprognostic (1.33e-1)"	"unprognostic (2.53e-3)"	"unprognostic (2.52e-5)"
AMT	"GCST, NKH"	ENSG00000145020	Aminomethyltransferase	P48728	3	49416778-49422685	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins"		"Aminotransferase, Transferase"	"Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"liver: 49.1"	"Cell type enhanced"	"Detected in many"		"Proximal enterocytes: 12.4;Undifferentiated cells: 16.5"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Immune cell enhanced"	"Detected in many"		"NK-cell: 7.9"	"Low lineage specificity"	"Detected in many"			"Cancer enhanced"	"Detected in many"		"liver cancer: 10.1;testis cancer: 9.0"	"Heart muscle - Cardiomyocytes, Liver - Hepatocytes"									HPA005566	Supported		Supported	Nucleoplasm,Mitochondria		NA	NA			"Cluster 40: NK-cells - Unknown function"	"Cluster 35: Non-specific - Unknown function"	"Cluster 35: Liver cancer - Metabolism"	"Cluster 64: Non-specific - Transcription"	Mitochondria	Nucleoplasm	"HPA005566: AB_1844811"	"unprognostic (2.10e-2)"	"unprognostic (1.65e-2)"	"unprognostic (1.82e-1)"	"unprognostic (9.14e-3)"	"unprognostic (4.04e-1)"	"unprognostic (1.11e-2)"	"unprognostic (2.81e-1)"	"unprognostic (2.17e-3)"	"unprognostic (1.94e-1)"	"unprognostic (3.29e-1)"	"unprognostic (7.17e-3)"	"unprognostic (1.88e-1)"	"prognostic favorable (3.90e-8)"	"unprognostic (4.40e-1)"	"unprognostic (1.91e-1)"	"unprognostic (3.60e-1)"	"unprognostic (1.98e-3)"
DHFR		ENSG00000228716	"Dihydrofolate reductase"	P00374	5	80626226-80654983	"Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins"	"Methotrexate resistance, One-carbon metabolism"	"Oxidoreductase, RNA-binding"	"Cancer-related genes, Disease variant, FDA approved drug targets"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Erythroid cells: 147.5;Plasma cells: 67.8;Spermatocytes: 101.7"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Adipocytes (Subcutaneous), Adipose visceral - Adipocytes (Visceral), Liver - Hepatocytes, Testis - Early spermatids, Testis - Spermatocytes"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB037129, HPA051465"	Uncertain		Uncertain	Mitochondria		NA	Yes			"Cluster 4: T-regs - Cell cycle regulation"	"Cluster 53: Non-specific - Cell cycle regulation"	"Cluster 45: Non-specific - Cell proliferation"	"Cluster 43: Non-specific - Cell proliferation"	Mitochondria		"CAB037129: AB_439683, HPA051465: AB_2681494"	"unprognostic (1.44e-2)"	"unprognostic (1.03e-2)"	"unprognostic (2.24e-3)"	"unprognostic (2.91e-3)"	"unprognostic (3.27e-1)"	"unprognostic (1.32e-1)"	"unprognostic (2.83e-2)"	"unprognostic (2.35e-2)"	"unprognostic (2.02e-2)"	"unprognostic (4.19e-3)"	"unprognostic (1.83e-2)"	"unprognostic (2.55e-1)"	"unprognostic (1.15e-2)"	"unprognostic (1.82e-2)"	"unprognostic (2.49e-1)"	"unprognostic (1.57e-1)"	"unprognostic (1.09e-1)"
DHFR2	"DHFRL1, DHFRP4, FLJ16119"	ENSG00000178700	"Dihydrofolate reductase 2"	Q86XF0	3	94047836-94063389	"Enzymes, Metabolic proteins, Predicted intracellular proteins"	"One-carbon metabolism"	Oxidoreductase		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Early spermatids: 51.3"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Thyroid - Thyroid glandular cells"									HPA051465	Uncertain		Supported	Mitochondria		NA	NA			"Cluster 32: T-cells - Unknown function"	"Cluster 89: Fibroblasts - ECM organization"	"Cluster 43: Non-specific - Mitochondria"	"Cluster 57: Early spermatids - Flagellum & Golgi organization"	Mitochondria		"HPA051465: AB_2681494"	"unprognostic (1.16e-1)"	"unprognostic (1.15e-1)"	"unprognostic (1.10e-2)"	"unprognostic (3.50e-2)"	"unprognostic (2.07e-1)"	"unprognostic (1.38e-1)"	"unprognostic (5.92e-2)"	"unprognostic (1.33e-1)"	"unprognostic (1.12e-1)"	"unprognostic (4.62e-2)"	"unprognostic (2.95e-1)"	"unprognostic (1.52e-1)"	"prognostic favorable (2.30e-6)"	"unprognostic (1.63e-1)"	"unprognostic (1.79e-1)"	"unprognostic (1.13e-1)"	"unprognostic (2.96e-2)"
DLD	"DLDH, E3, GCSL, LAD, OGDC-E3"	ENSG00000091140	"Dihydrolipoamide dehydrogenase"	P09622	7	107891162-107931730	"Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins"		Oxidoreductase	"Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"tongue: 357.0"	"Cell type enhanced"	"Detected in all"		"Cardiomyocytes: 346.6"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Adipocytes (Subcutaneous), Adipose visceral - Adipocytes (Visceral), Breast - Adipocytes (Breast), Heart muscle - Cardiomyocytes, Liver - Hepatocytes"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA044849	Supported		Approved	Nucleoplasm,Mitochondria		NA	NA		10000000	"Cluster 45: Eosinophils - Innate immune response"	"Cluster 8: Non-specific - Mitochondria"	"Cluster 31: Non-specific - Transcription"	"Cluster 77: Cardiomyocytes - Muscle contraction"	Mitochondria	Nucleoplasm	"HPA044849: AB_2679111"	"unprognostic (2.01e-3)"	"unprognostic (2.26e-1)"	"unprognostic (1.27e-2)"	"unprognostic (9.27e-2)"	"unprognostic (5.01e-3)"	"unprognostic (9.27e-2)"	"unprognostic (2.48e-1)"	"unprognostic (2.83e-2)"	"unprognostic (1.19e-1)"	"unprognostic (3.95e-2)"	"unprognostic (9.43e-2)"	"unprognostic (7.35e-2)"	"prognostic favorable (7.58e-9)"	"unprognostic (4.08e-2)"	"unprognostic (1.88e-1)"	"unprognostic (4.45e-3)"	"unprognostic (1.18e-1)"
FPGS		ENSG00000136877	"Folylpolyglutamate synthase"	Q05932	9	127794597-127814327	"Enzymes, Metabolic proteins, Predicted intracellular proteins"	"One-carbon metabolism"	Ligase		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Thymic epithelial cells: 80.4"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Adipocytes (Subcutaneous)"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA050488	Approved				"Intracellular and membrane"	NA	NA			"Cluster 22: NK-cells - Unknown function"	"Cluster 18: Non-specific - Mitochondria"	"Cluster 23: B-cell cancers - Adaptive immune response"	"Cluster 61: Non-specific - Transcription"			"HPA050488: AB_2681143"	"unprognostic (6.37e-2)"	"unprognostic (1.06e-1)"	"unprognostic (1.02e-1)"	"prognostic favorable (9.08e-4)"	"unprognostic (1.25e-1)"	"unprognostic (2.67e-1)"	"unprognostic (1.00e-1)"	"unprognostic (1.89e-1)"	"unprognostic (6.25e-2)"	"unprognostic (2.63e-1)"	"unprognostic (1.16e-1)"	"unprognostic (6.97e-2)"	"unprognostic (1.76e-1)"	"unprognostic (8.54e-3)"	"unprognostic (2.61e-1)"	"unprognostic (1.58e-1)"	"unprognostic (1.55e-2)"
FTCD		ENSG00000160282	"Formimidoyltransferase cyclodeaminase"	O95954	21	46136262-46155579	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"	"Histidine metabolism"	"Lyase, Multifunctional enzyme, Transferase"	"Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	6	"liver: 939.8"	"Cell type enhanced"	"Detected in some"		"Cholangiocytes: 107.8;Early spermatids: 105.2;Hepatocytes: 369.0;Late spermatids: 125.9;Proximal tubular cells: 315.4"	"Cancer enriched"	"Detected in some"	8	"liver cancer: 87.3"	"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enhanced"	"Detected in some"		"liver cancer: 7.6"	"Kidney - Proximal tubular cells, Liver - Hepatocytes"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"HPA020073, HPA030928, HPA030929, HPA036114"	Enhanced		Approved	"Plasma membrane,Cytosol"		No	NA		1600000	"Cluster 4: T-regs - Cell cycle regulation"	"Cluster 85: Liver - Metabolism"	"Cluster 35: Liver cancer - Metabolism"	"Cluster 60: Proximal tubular cells - Absorption"	Cytosol	"Plasma membrane"	"HPA020073: AB_1849005, HPA030928: AB_2673664, HPA030929: AB_2673665, HPA036114: AB_2674947"	"unprognostic (1.71e-1)"	"unprognostic (2.27e-1)"	"unprognostic (4.62e-5)"	"unprognostic (2.90e-2)"	"unprognostic (1.13e-1)"	"unprognostic (2.96e-1)"	"prognostic favorable (1.70e-4)"	"unprognostic (1.85e-1)"	"unprognostic (2.67e-1)"	"unprognostic (1.99e-1)"	"prognostic favorable (6.78e-5)"	"unprognostic (1.80e-1)"	"prognostic favorable (5.78e-4)"	"unprognostic (3.80e-2)"	"unprognostic (3.60e-1)"	"unprognostic (9.37e-2)"	"unprognostic (2.10e-1)"
GCSH		ENSG00000140905	"Glycine cleavage system protein H"	P23434	16	81081945-81096395	"Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins"				"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Cytotrophoblasts: 505.4;Extravillous trophoblasts: 1288.6;Proximal tubular cells: 493.3"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Adipocytes (Subcutaneous), Adipose visceral - Adipocytes (Visceral), Heart muscle - Cardiomyocytes, Kidney - Proximal tubular cells, Thyroid - Thyroid glandular cells"									"HPA041368, HPA057079"	Supported		Approved	Vesicles	"Intracellular and membrane"	NA	NA		50000	"Cluster 47: Plasmacytoid DCs - Protein folding"	"Cluster 39: Non-specific - Mitochondria"	"Cluster 36: Non-specific - Unknown function"	"Cluster 54: Extravillous trophoblasts - Unknown function"	Vesicles		"HPA041368: AB_10804001, HPA057079: "	"unprognostic (4.09e-2)"	"unprognostic (2.98e-2)"	"unprognostic (2.29e-1)"	"unprognostic (2.47e-3)"	"unprognostic (2.55e-3)"	"unprognostic (4.87e-2)"	"unprognostic (1.38e-1)"	"unprognostic (1.67e-1)"	"unprognostic (2.75e-1)"	"unprognostic (1.96e-2)"	"unprognostic (6.92e-2)"	"unprognostic (2.80e-2)"	"prognostic favorable (6.26e-6)"	"unprognostic (1.12e-2)"	"unprognostic (2.59e-1)"	"unprognostic (6.31e-2)"	"unprognostic (6.47e-2)"
GGH		ENSG00000137563	"Gamma-glutamyl hydrolase"	Q92820	8	63014881-63039407	"Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins"		Hydrolase		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"kidney: 125.7;liver: 188.6"	"Cell type enhanced"	"Detected in many"		"Cytotrophoblasts: 523.6;Early spermatids: 339.3;Extravillous trophoblasts: 311.4;Late spermatids: 262.8;Syncytiotrophoblasts: 734.6"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Immune cell enriched"	"Detected in many"	5	"plasmacytoid DC: 30.6"	"Lineage enriched"	"Detected in all"	5	"dendritic cells: 30.6"	"Low cancer specificity"	"Detected in all"			"Kidney - Proximal tubular cells, Liver - Hepatocytes, Stomach - Mitotic cells (Stomach), Testis - Early spermatids, Testis - Late spermatids"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB019296, HPA025226"	Approved				"Intracellular and membrane"	NA	NA		1200000000	"Cluster 47: Plasmacytoid DCs - Protein folding"	"Cluster 81: Kidney & Liver - Metabolism"	"Cluster 25: Non-specific - Basic cellular processes"	"Cluster 28: Cytotrophoblasts - Unknown function"			"CAB019296: , HPA025226: AB_1849645"	"unprognostic (9.29e-2)"	"unprognostic (1.22e-1)"	"unprognostic (5.48e-3)"	"prognostic unfavorable (3.99e-7)"	"unprognostic (5.57e-2)"	"unprognostic (1.08e-1)"	"unprognostic (1.14e-1)"	"prognostic unfavorable (1.65e-4)"	"unprognostic (1.95e-2)"	"unprognostic (1.60e-1)"	"unprognostic (2.11e-2)"	"unprognostic (1.32e-1)"	"unprognostic (1.69e-2)"	"unprognostic (9.62e-3)"	"unprognostic (1.50e-1)"	"unprognostic (2.36e-1)"	"unprognostic (6.50e-2)"
GLDC	"GCSP, NKH"	ENSG00000178445	"Glycine decarboxylase"	P23378	9	6532467-6645729	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"		Oxidoreductase	"Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	5	"liver: 173.5"	"Cell type enhanced"	"Detected in many"		"Cytotrophoblasts: 82.8;Extravillous trophoblasts: 39.5;Hepatocytes: 79.6;Oligodendrocyte precursor cells: 50.1;Syncytiotrophoblasts: 35.6"	"Cancer enhanced"	"Detected in many"		"testis cancer: 41.4"	"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enhanced"	"Detected in all"		"Myeloma: 36.6"	"Breast - Plasma cells, Kidney - Proximal tubular cells, Skin - Sebaceous gland cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA002318, HPA052887"	Enhanced		Supported	Nucleoplasm,Mitochondria		NA	NA		740000	"Cluster 37: B-cells - Transcription"	"Cluster 15: Liver - Metabolism"	"Cluster 6: BEWO - Unknown function"	"Cluster 28: Cytotrophoblasts - Unknown function"	Mitochondria	Nucleoplasm	"HPA002318: AB_1849700, HPA052887: AB_2681980"	"unprognostic (6.73e-2)"	"unprognostic (1.19e-1)"	"unprognostic (6.50e-2)"	"prognostic unfavorable (5.24e-5)"	"unprognostic (1.50e-1)"	"unprognostic (7.87e-2)"	"unprognostic (1.81e-1)"	"unprognostic (1.50e-1)"	"unprognostic (2.40e-1)"	"unprognostic (1.74e-1)"	"unprognostic (2.47e-2)"	"unprognostic (2.69e-1)"	"prognostic favorable (3.50e-4)"	"unprognostic (1.65e-2)"	"unprognostic (1.27e-1)"	"unprognostic (5.62e-3)"	"unprognostic (1.17e-2)"
GPHN	KIAA1385	ENSG00000171723	Gephyrin	Q9NQX3	14	66507407-67181803	"Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"	"Molybdenum cofactor biosynthesis"	"Multifunctional enzyme, Transferase"	"Cancer-related genes, Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"liver: 62.4"	"Group enriched"	"Detected in many"	4	"Astrocytes: 477.6;Excitatory neurons: 676.4;Inhibitory neurons: 846.3;Oligodendrocyte precursor cells: 551.6;Oligodendrocytes: 564.0"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Liver - Hepatocytes, Thyroid - Thyroid glandular cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA003116, CAB004419, HPA024694"	Enhanced		Approved	Vesicles,Cytosol		NA	NA		6900	"Cluster 16: MAIT-cells - Unknown function"	"Cluster 15: Liver - Metabolism"	"Cluster 46: Non-specific - Unknown function"	"Cluster 37: Neurons - Neuronal signaling"	Vesicles	Cytosol	"CAB004419: AB_627670, HPA003116: AB_1078963, HPA024694: AB_1849616"	"unprognostic (8.37e-2)"	"unprognostic (2.53e-2)"	"unprognostic (2.42e-1)"	"unprognostic (1.20e-1)"	"unprognostic (5.14e-2)"	"unprognostic (4.89e-3)"	"unprognostic (8.29e-2)"	"unprognostic (1.41e-2)"	"unprognostic (1.42e-1)"	"unprognostic (2.23e-1)"	"unprognostic (2.49e-2)"	"unprognostic (8.54e-2)"	"prognostic favorable (5.25e-12)"	"unprognostic (9.81e-2)"	"unprognostic (2.27e-1)"	"unprognostic (7.50e-2)"	"prognostic unfavorable (4.61e-5)"
MOCS1	MOCOD	ENSG00000124615	"Molybdenum cofactor synthesis 1"	Q9NZB8	6	39899578-39934551	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"	"Molybdenum cofactor biosynthesis"	Lyase	"Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in many"			"Cell type enhanced"	"Detected in many"		"Cytotrophoblasts: 33.3;Hepatocytes: 31.8;Sertoli cells: 30.4;Smooth muscle cells: 22.1"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Low cancer specificity"	"Detected in many"			"Adipose visceral - Adipocytes (Visceral), Liver - Hepatocytes"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA045783, HPA058177, HPA075505"	Uncertain		Enhanced	Cytosol		NA	NA			"Cluster 32: T-cells - Unknown function"	"Cluster 15: Liver - Metabolism"	"Cluster 5: Non-specific - Unknown function"	"Cluster 72: Smooth muscle cells - ECM organization"	Cytosol		"HPA045783: AB_10960058, HPA058177: AB_2683629, HPA075505: AB_2686751"	"unprognostic (1.22e-1)"	"prognostic unfavorable (1.07e-5)"	"unprognostic (3.26e-2)"	"unprognostic (1.44e-1)"	"unprognostic (9.03e-2)"	"unprognostic (1.99e-1)"	"unprognostic (2.61e-2)"	"unprognostic (4.85e-2)"	"unprognostic (3.14e-2)"	"unprognostic (1.08e-1)"	"prognostic favorable (6.07e-5)"	"unprognostic (5.34e-3)"	"unprognostic (1.21e-1)"	"unprognostic (3.97e-3)"	"unprognostic (2.78e-1)"	"unprognostic (2.93e-1)"	"unprognostic (6.21e-2)"
MOCS2	"MOCO1, MOCS2A, MOCS2B"	ENSG00000164172	"Molybdenum cofactor synthesis 2"	"O96007, O96033"	5	53095679-53110063	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"	"Molybdenum cofactor biosynthesis"	Transferase	"Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Cardiomyocytes: 219.8;Distal tubular cells: 513.1;Proximal tubular cells: 272.2"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Heart muscle - Cardiomyocytes, Liver - Hepatocytes, Thyroid - Thyroid glandular cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA037679, HPA037680"	Approved		Supported	"Nucleoplasm,Nuclear speckles,Cytosol"		NA	NA			"Cluster 15: NK-cells - Transcription"	"Cluster 39: Non-specific - Mitochondria"	"Cluster 57: Non-specific - Translation"	"Cluster 16: Non-specific - RNA binding"	Cytosol	"Nucleoplasm, Nuclear speckles"	"HPA037679: AB_2675604, HPA037680: AB_10673635"	"unprognostic (3.27e-1)"	"unprognostic (3.11e-2)"	"unprognostic (2.82e-1)"	"unprognostic (8.37e-3)"	"unprognostic (2.12e-1)"	"unprognostic (3.48e-2)"	"unprognostic (1.60e-2)"	"unprognostic (1.33e-1)"	"unprognostic (6.66e-2)"	"unprognostic (7.59e-2)"	"unprognostic (2.41e-3)"	"unprognostic (1.85e-1)"	"prognostic favorable (3.68e-6)"	"unprognostic (1.04e-1)"	"unprognostic (1.04e-2)"	"unprognostic (2.04e-1)"	"unprognostic (5.86e-2)"
MTHFD1	"MTHFC, MTHFD"	ENSG00000100714	"Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1"		14	64388031-64463457	"Human disease related genes, Metabolic proteins, Predicted intracellular proteins"				"Evidence at protein level"	"Evidence at protein level"			"Tissue enriched"	"Detected in all"	6	"liver: 356.9"	"Cell type enhanced"	"Detected in all"		"Hepatocytes: 145.7"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Adipocytes (Subcutaneous), Adipose visceral - Adipocytes (Visceral), Breast - Adipocytes (Breast), Liver - Hepatocytes"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA000704, HPA001290, HPA015006, HPA050052"	Approved		Enhanced	Cytosol		NA	Yes			"Cluster 43: B-cells - Humoral immune response"	"Cluster 85: Liver - Metabolism"	"Cluster 46: Non-specific - Unknown function"	"Cluster 16: Non-specific - RNA binding"	Cytosol		"HPA000704: AB_1079424, HPA001290: AB_1854177, HPA015006: AB_1854178, HPA050052: AB_2680998"	"unprognostic (3.58e-2)"	"unprognostic (5.50e-3)"	"unprognostic (1.24e-1)"	"unprognostic (2.46e-2)"	"unprognostic (1.37e-1)"	"unprognostic (7.01e-2)"	"unprognostic (8.85e-3)"	"unprognostic (7.62e-3)"	"unprognostic (1.28e-1)"	"unprognostic (2.29e-2)"	"prognostic unfavorable (6.96e-4)"	"unprognostic (1.84e-1)"	"prognostic favorable (5.93e-5)"	"unprognostic (2.45e-2)"	"unprognostic (1.75e-1)"	"unprognostic (7.30e-2)"	"unprognostic (2.29e-2)"
MTHFD1L	"DKFZP586G1517, FLJ21145, FTHFSDC1"	ENSG00000120254	"Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"	Q6UB35	6	150865679-151101887	"Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins"	"One-carbon metabolism"	Ligase		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in many"			"Cell type enhanced"	"Detected in many"		"Excitatory neurons: 82.8;Extravillous trophoblasts: 186.1;Granulosa cells: 86.0;Microglial cells: 123.1;Syncytiotrophoblasts: 86.6"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in some"			"Group enriched"	"Detected in many"	4	"dendritic cells: 1.1;T-cells: 1.8"	"Low cancer specificity"	"Detected in all"			"Heart muscle - Endothelial cells, Skeletal muscle - Endothelial cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA015006, HPA029040, HPA029041, HPA050052, HPA074911"	Approved		Enhanced	Mitochondria		NA	NA		89000	"Cluster 4: T-regs - Cell cycle regulation"	"Cluster 21: Non-specific - Transcription"	"Cluster 37: Ovarian cancer RMG-I - Cellular stress response"	"Cluster 17: Granulosa cells - Transcription regulation"	Mitochondria		"HPA015006: AB_1854178, HPA029040: AB_2672879, HPA029041: AB_2672880, HPA050052: AB_2680998, HPA074911: AB_2686723"	"unprognostic (3.66e-2)"	"prognostic unfavorable (1.68e-5)"	"unprognostic (1.02e-1)"	"prognostic unfavorable (7.28e-4)"	"unprognostic (3.25e-1)"	"prognostic unfavorable (5.10e-4)"	"prognostic unfavorable (8.33e-5)"	"unprognostic (6.35e-3)"	"unprognostic (2.45e-1)"	"unprognostic (1.44e-1)"	"unprognostic (1.02e-1)"	"unprognostic (1.32e-1)"	"unprognostic (1.11e-2)"	"unprognostic (2.93e-2)"	"unprognostic (3.51e-1)"	"unprognostic (2.91e-1)"	"prognostic unfavorable (8.69e-5)"
MTHFD2		ENSG00000065911	"Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase"	P13995	2	74186172-74217565	"Enzymes, Metabolic proteins, Predicted intracellular proteins"	"One-carbon metabolism"	"Hydrolase, Multifunctional enzyme, Oxidoreductase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Langerhans cells: 278.1;Smooth muscle cells: 161.4"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"				"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB003684, HPA049657"	Approved		Supported	Mitochondria	"Intracellular and membrane"	NA	NA			"Cluster 45: Eosinophils - Innate immune response"	"Cluster 52: Non-specific - Ribosome"	"Cluster 37: Ovarian cancer RMG-I - Cellular stress response"	"Cluster 72: Smooth muscle cells - ECM organization"	Mitochondria		"CAB003684: AB_425867, HPA049657: AB_2680842"	"unprognostic (1.82e-3)"	"unprognostic (4.60e-2)"	"unprognostic (8.12e-2)"	"prognostic unfavorable (2.07e-5)"	"prognostic favorable (1.01e-4)"	"unprognostic (3.10e-3)"	"unprognostic (2.24e-3)"	"unprognostic (4.75e-3)"	"unprognostic (2.64e-2)"	"unprognostic (3.96e-2)"	"unprognostic (3.76e-3)"	"unprognostic (3.57e-3)"	"prognostic unfavorable (1.11e-16)"	"unprognostic (3.66e-2)"	"unprognostic (6.52e-2)"	"unprognostic (9.07e-2)"	"unprognostic (2.34e-3)"
MTHFD2L	MGC72244	ENSG00000163738	"Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like"	Q9H903	4	74114174-74303099	"Enzymes, Metabolic proteins, Predicted intracellular proteins"	"Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis"	"Hydrolase, Multifunctional enzyme, Oxidoreductase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in many"			"Low cell type specificity"	"Detected in all"			"Low cancer specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Lung - Alveolar cells type 2"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA035434	Uncertain					NA	NA			"Cluster 14: Monocytes - Unknown function"	"Cluster 32: Brain & Lymphoid tissue - Unknown function"	"Cluster 45: Non-specific - Cell proliferation"	"Cluster 30: Breast - Lactation"			"HPA035434: AB_10601038"	"unprognostic (2.01e-1)"	"unprognostic (2.19e-1)"	"unprognostic (2.03e-1)"	"unprognostic (2.32e-2)"	"unprognostic (1.52e-2)"	"unprognostic (4.09e-2)"	"unprognostic (2.67e-2)"	"unprognostic (7.73e-3)"	"unprognostic (1.42e-4)"	"unprognostic (3.45e-3)"	"unprognostic (4.23e-2)"	"unprognostic (5.07e-2)"	"unprognostic (1.44e-1)"	"unprognostic (3.16e-2)"	"unprognostic (1.19e-1)"	"unprognostic (3.00e-1)"	"unprognostic (1.81e-3)"
MTHFR		ENSG00000177000	"Methylenetetrahydrofolate reductase"	P42898	1	11785723-11806455	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"		"Allosteric enzyme, Oxidoreductase"	"Disease variant, Schizophrenia"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Skeletal myocytes: 88.1"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"				"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA063389, HPA076180, HPA077255"	Enhanced		Approved	"Cell Junctions"		NA	NA			"Cluster 14: Monocytes - Unknown function"	"Cluster 68: Epididymis - Unknown function"	"Cluster 32: Myeloid leukemia - Oxygen transport"	"Cluster 11: Non-specific - Transcription"	"Cell Junctions"		"HPA063389: AB_2685001, HPA076180: , HPA077255: "	"unprognostic (3.25e-2)"	"unprognostic (8.19e-2)"	"unprognostic (4.48e-2)"	"unprognostic (2.11e-2)"	"unprognostic (1.34e-1)"	"prognostic favorable (3.97e-5)"	"prognostic unfavorable (1.19e-4)"	"unprognostic (1.75e-2)"	"unprognostic (2.85e-1)"	"unprognostic (8.69e-2)"	"prognostic favorable (4.81e-5)"	"unprognostic (3.10e-1)"	"prognostic favorable (2.12e-4)"	"unprognostic (2.35e-3)"	"unprognostic (2.94e-1)"	"unprognostic (4.14e-2)"	"unprognostic (1.80e-2)"
MTHFS	HsT19268	ENSG00000136371	"Methenyltetrahydrofolate synthetase"	P49914	15	79833585-79897379	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"		Ligase	"Disease variant, Epilepsy"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in all"	5	"liver: 253.4"	"Cell type enhanced"	"Detected in many"		"Hepatocytes: 225.7;Proximal tubular cells: 201.6;Syncytiotrophoblasts: 254.9"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Immune cell enhanced"	"Detected in all"		"neutrophil: 134.1"	"Group enriched"	"Detected in all"	5	"granulocytes: 134.1;monocytes: 49.1"	"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Adipocytes (Subcutaneous), Kidney - Proximal tubular cells, Kidney - Proximal tubular cells, Liver - Hepatocytes, Testis - Sertoli cells, Thyroid - Thyroid glandular cells"									"HPA008067, HPA054177"	Approved		Supported	Cytosol		NA	NA		13000	"Cluster 8: Neutrophils - Inflammatory response"	"Cluster 62: Liver - Hemostasis"	"Cluster 46: Non-specific - Unknown function"	"Cluster 60: Proximal tubular cells - Absorption"	Cytosol		"HPA008067: AB_1078882, HPA054177: AB_2682405"	"unprognostic (4.57e-2)"	"unprognostic (9.76e-2)"	"unprognostic (6.11e-2)"	"unprognostic (1.82e-1)"	"prognostic unfavorable (8.52e-4)"	"unprognostic (9.13e-3)"	"prognostic favorable (1.29e-6)"	"unprognostic (1.34e-2)"	"unprognostic (1.03e-1)"	"unprognostic (6.18e-3)"	"unprognostic (2.91e-2)"	"unprognostic (2.76e-1)"	"prognostic favorable (2.04e-4)"	"unprognostic (1.36e-1)"	"unprognostic (2.85e-1)"	"unprognostic (7.60e-2)"	"unprognostic (2.90e-1)"
QDPR	"DHPR, PKU2, SDR33C1"	ENSG00000151552	"Quinoid dihydropteridine reductase"	P09417	4	17460261-17512206	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins"	"Tetrahydrobiopterin biosynthesis"	Oxidoreductase	"Disease variant, Phenylketonuria"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"brain: 752.2;choroid plexus: 301.8"	"Group enriched"	"Detected in many"	4	"Enteroendocrine cells: 166.6;Hepatocytes: 382.4;Melanocytes: 184.6;Muller glia cells: 380.3;Oligodendrocytes: 454.4;Proximal tubular cells: 396.6"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Adipocytes (Subcutaneous), Adipose visceral - Adipocytes (Visceral), Breast - Adipocytes (Breast), Heart muscle - Cardiomyocytes, Kidney - Proximal tubular cells, Liver - Hepatocytes, Prostate - Prostate glandular cells, Skin - Eccrine sweat gland cells, Thyroid - Thyroid glandular cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA058951, HPA065649"	Enhanced		Approved	Mitochondria		NA	NA		2500000	"Cluster 47: Plasmacytoid DCs - Protein folding"	"Cluster 70: Brain - Nervous system development"	"Cluster 16: Skin cancer - Melanocyte processes"	"Cluster 68: Muller glia cells - Visual perception"	Mitochondria		"HPA058951: AB_2683861, HPA065649: AB_2685526"	"unprognostic (1.30e-2)"	"unprognostic (4.29e-1)"	"unprognostic (8.27e-2)"	"unprognostic (2.52e-1)"	"unprognostic (1.21e-1)"	"unprognostic (1.20e-1)"	"unprognostic (3.29e-3)"	"unprognostic (3.80e-3)"	"unprognostic (1.19e-1)"	"unprognostic (1.45e-1)"	"unprognostic (6.82e-3)"	"unprognostic (2.07e-1)"	"prognostic favorable (7.84e-6)"	"unprognostic (1.58e-1)"	"unprognostic (2.60e-1)"	"unprognostic (9.01e-2)"	"unprognostic (3.19e-1)"