Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific nTPM"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific nTPM"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific FPKM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific nTPM"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific nTPM"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific nTPM"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific nTPM"	"RNA tissue cell type enrichment"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific nTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific nTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Blood expression cluster"	"Tissue expression cluster"	"Cell line expression cluster"	"Single cell expression cluster"	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Pathology prognostics - Breast cancer"	"Pathology prognostics - Cervical cancer"	"Pathology prognostics - Colorectal cancer"	"Pathology prognostics - Endometrial cancer"	"Pathology prognostics - Glioma"	"Pathology prognostics - Head and neck cancer"	"Pathology prognostics - Liver cancer"	"Pathology prognostics - Lung cancer"	"Pathology prognostics - Melanoma"	"Pathology prognostics - Ovarian cancer"	"Pathology prognostics - Pancreatic cancer"	"Pathology prognostics - Prostate cancer"	"Pathology prognostics - Renal cancer"	"Pathology prognostics - Stomach cancer"	"Pathology prognostics - Testis cancer"	"Pathology prognostics - Thyroid cancer"	"Pathology prognostics - Urothelial cancer"
BCO2	"B-DIOX-II, BCDO2, FLJ34464"	ENSG00000197580	"Beta-carotene oxygenase 2"	Q9BYV7	11	112175510-112224699	"Enzymes, Metabolic proteins, Predicted intracellular proteins"	"Lipid metabolism"	"Dioxygenase, Oxidoreductase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"heart muscle: 47.2;liver: 52.3;retina: 55.9"	"Cell type enhanced"	"Detected in many"		"Cone photoreceptor cells: 191.3;Hepatocytes: 67.9;Rod photoreceptor cells: 264.0"	"Low cancer specificity"	"Detected in some"			"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Low cancer specificity"	"Detected in some"			"Adipose visceral - Mesothelial cells, Heart muscle - Cardiomyocytes, Lung - Respiratory ciliated cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA061542	Supported					NA	NA			"Cluster 22: NK-cells - Unknown function"	"Cluster 39: Non-specific - Mitochondria"	"Cluster 22: Rhabdoid cancers - Neuronal signaling"	"Cluster 44: Photoreceptor cells - Visual perception"			"HPA061542: "	"unprognostic (2.92e-1)"	"unprognostic (1.89e-1)"	"unprognostic (3.76e-2)"	"unprognostic (1.40e-1)"	"unprognostic (1.91e-1)"	"unprognostic (1.50e-2)"	"unprognostic (7.60e-3)"	"unprognostic (1.88e-1)"	"unprognostic (3.18e-2)"	"unprognostic (6.40e-2)"	"unprognostic (2.39e-2)"	"unprognostic (6.91e-2)"	"unprognostic (1.36e-4)"	"unprognostic (2.31e-2)"	"unprognostic (9.86e-2)"	"unprognostic (1.07e-2)"	"unprognostic (1.34e-1)"
CYP11B1	"CPN1, CYP11B, FHI, P450C11"	ENSG00000160882	"Cytochrome P450 family 11 subfamily B member 1"	P15538	8	142872356-142879846	"Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins"	"Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroidogenesis"	"Monooxygenase, Oxidoreductase"	"Congenital adrenal hyperplasia, Disease variant, FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in some"	877	"adrenal gland: 3686.5"	"Group enriched"	"Detected in some"	220	"Early spermatids: 59.7;Late spermatids: 83.5"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Testis - Late spermatids"									"HPA049171, HPA049565, HPA056348, HPA057752"	Supported		Approved	Mitochondria		NA	NA				"Cluster 17: Adrenal gland - Steroid metabolism"		"Cluster 6: Late spermatids - Spermatogenesis"	Mitochondria		"HPA049171: AB_2680661, HPA049565: , HPA056348: AB_2683104, HPA057752: AB_2683516"																	
CYP11B2	"ALDOS, CPN2, CYP11B, CYP11BL, P-450C18, P450aldo"	ENSG00000179142	"Cytochrome P450 family 11 subfamily B member 2"	P19099	8	142910559-142917843	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins"	"Lipid metabolism, Steroid metabolism, Steroidogenesis"	"Monooxygenase, Oxidoreductase"	"Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in single"	603	"adrenal gland: 179.0"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"												"HPA049171, HPA049565, HPA056348, HPA057752"	Supported		Uncertain	Mitochondria		NA	NA				"Cluster 17: Adrenal gland - Steroid metabolism"			Mitochondria		"HPA049171: AB_2680661, HPA049565: , HPA056348: AB_2683104, HPA057752: AB_2683516"																	
CYP17A1	"CPT7, CYP17, P450C17, S17AH"	ENSG00000148795	"Cytochrome P450 family 17 subfamily A member 1"	P05093	10	102830531-102837472	"Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins"	"Lipid metabolism, Steroidogenesis"	"Lyase, Monooxygenase, Oxidoreductase"	"Congenital adrenal hyperplasia, Disease variant, FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	84	"adrenal gland: 8229.5"	"Cell type enriched"	"Detected in some"	13	"Theca cells: 1175.8"	"Cancer enriched"	"Detected in many"	5	"liver cancer: 22.7"	"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"				"Not detected"	"Not detected"			"Not detected"	"Not detected"			HPA048533	Enhanced		Approved	Vesicles	"Intracellular and membrane"	NA	NA				"Cluster 17: Adrenal gland - Steroid metabolism"	"Cluster 2: DU4475 - Unknown function"	"Cluster 17: Granulosa cells - Transcription regulation"	Vesicles		"HPA048533: AB_2680432"	"unprognostic (1.07e-2)"	"unprognostic (8.84e-2)"	"unprognostic (3.01e-2)"	"unprognostic (9.08e-2)"	"unprognostic (1.91e-1)"	"unprognostic (6.29e-2)"	"unprognostic (2.92e-3)"	"unprognostic (2.39e-4)"	"unprognostic (8.26e-2)"	"unprognostic (2.35e-1)"	"unprognostic (5.92e-3)"	"unprognostic (1.13e-1)"	"prognostic favorable (5.43e-7)"	"unprognostic (1.07e-1)"	"unprognostic (5.56e-2)"	"unprognostic (1.66e-2)"	"unprognostic (2.94e-4)"
CYP21A2	"CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B"	ENSG00000231852	"Cytochrome P450 family 21 subfamily A member 2"	P08686	6	32038327-32041644	"Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins"	"Lipid metabolism, Steroidogenesis"	"Monooxygenase, Oxidoreductase"	"Congenital adrenal hyperplasia, Disease variant"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	46	"adrenal gland: 2041.7"	"Cell type enhanced"	"Detected in some"		"Cholangiocytes: 1.9;Hepatocytes: 11.0;Proximal tubular cells: 1.9;Salivary duct cells: 3.9;Thymic epithelial cells: 2.8"	"Cancer enhanced"	"Detected in some"		"liver cancer: 2.7"	"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Kidney - Proximal tubular cells"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"HPA048979, HPA053371"	Enhanced					NA	NA				"Cluster 17: Adrenal gland - Steroid metabolism"	"Cluster 11: Lymphoma - Adaptive immune response"	"Cluster 29: Hepatocytes - Metabolism"			"HPA048979: AB_2680584, HPA053371: AB_2682131"	"unprognostic (1.03e-2)"	"unprognostic (1.65e-1)"	"unprognostic (1.02e-4)"	"unprognostic (2.58e-1)"	"unprognostic (2.97e-1)"	"unprognostic (2.93e-2)"	"unprognostic (2.76e-2)"	"unprognostic (8.75e-2)"	"unprognostic (1.39e-1)"	"unprognostic (1.71e-1)"	"unprognostic (1.41e-1)"	"unprognostic (1.93e-1)"	"unprognostic (6.67e-7)"	"unprognostic (7.39e-2)"	"unprognostic (5.24e-2)"	"unprognostic (1.09e-1)"	"unprognostic (1.82e-1)"
HSD11B1	"HSD11, HSD11B, SDR26C1"	ENSG00000117594	"Hydroxysteroid 11-beta dehydrogenase 1"	P28845	1	209686178-209734949	"Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins"	"Lipid metabolism, Steroid metabolism"	Oxidoreductase	"Disease variant, FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	13	"liver: 968.3"	"Cell type enriched"	"Detected in many"	12	"Hepatocytes: 637.6"	"Cancer enriched"	"Detected in all"	28	"liver cancer: 197.4"	"Low region specificity"	"Detected in all"			"Immune cell enhanced"	"Detected in some"		"memory CD4 T-cell: 5.6"	"Lineage enriched"	"Detected in single"	17	"T-cells: 5.6"	"Cancer enhanced"	"Detected in many"		"Esophageal cancer: 19.5"	"Colon - Fibroblasts, Kidney - Fibroblasts"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA047729	Enhanced					NA	NA		110000	"Cluster 35: T-regs - Unknown function"	"Cluster 60: Liver - Hemostasis & Lipid metabolism"	"Cluster 59: Fibroblasts - Metabolism"	"Cluster 13: Hepatocytes - Oxidoreductase activity"			"HPA047729: AB_2680135"	"unprognostic (1.08e-3)"	"unprognostic (2.13e-1)"	"unprognostic (2.32e-1)"	"unprognostic (1.40e-1)"	"unprognostic (1.57e-1)"	"unprognostic (3.68e-1)"	"unprognostic (2.02e-2)"	"unprognostic (1.12e-1)"	"unprognostic (1.30e-1)"	"unprognostic (3.63e-2)"	"unprognostic (8.35e-3)"	"unprognostic (8.69e-2)"	"prognostic unfavorable (1.97e-10)"	"unprognostic (3.41e-2)"	"unprognostic (3.91e-2)"	"unprognostic (6.45e-2)"	"unprognostic (1.59e-2)"
HSD3B1	"HSD3B, HSDB3, SDR11E1"	ENSG00000203857	"Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1"	P14060	1	119507198-119515054	"Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins"	"Lipid metabolism, Steroid metabolism, Steroidogenesis"	"Isomerase, Multifunctional enzyme, Oxidoreductase"	"FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in some"	9	"placenta: 77.7"	"Cell type enriched"	"Detected in some"	4	"Syncytiotrophoblasts: 706.4"	"Cancer enriched"	"Detected in single"	4	"urothelial cancer: 1.6"	"Region enhanced"	"Detected in some"		"basal ganglia: 1.0;cerebral cortex: 1.0"	"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enhanced"	"Detected in some"		"Bladder cancer: 15.0;Gastric cancer: 19.5;testis cancer: 26.5"	"Skin - Sebaceous gland cells"									"HPA043261, HPA043264, HPA044028"	Supported		Approved	"Nucleoli,Endoplasmic reticulum,Cytokinetic bridge"		Yes	NA				"Cluster 28: Placenta - Pregnancy"	"Cluster 60: Keratinocytes - Epithelial cell function"	"Cluster 67: Syncytiotrophoblasts - Pregnancy"	"Nucleoli, Endoplasmic reticulum"	"Cytokinetic bridge"	"HPA043261: AB_2630368, HPA043264: AB_2678398, HPA044028: AB_2678781"			"unprognostic (1.53e-1)"				"unprognostic (7.11e-2)"					"unprognostic (1.15e-1)"		"unprognostic (1.04e-1)"			"prognostic favorable (4.59e-5)"
HSD3B2	SDR11E2	ENSG00000203859	"Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2"	P26439	1	119414931-119423035	"Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins"	"Lipid metabolism, Steroidogenesis"	"Isomerase, Multifunctional enzyme, Oxidoreductase"	"Congenital adrenal hyperplasia, Disease variant, FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in some"	56	"adrenal gland: 2174.8"	"Group enriched"	"Detected in some"	15	"Granulosa cells: 42.7;Proximal enterocytes: 52.4;Theca cells: 55.6"	"Cancer enhanced"	"Detected in single"		"testis cancer: 0.6"	"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enriched"	"Detected in single"	20	"skin cancer: 10.8"										"HPA043261, HPA043264, HPA044028"	Supported		Uncertain	"Nucleoli,Endoplasmic reticulum,Cytokinetic bridge"		Yes	NA				"Cluster 17: Adrenal gland - Steroid metabolism"	"Cluster 16: Skin cancer - Melanocyte processes"	"Cluster 17: Granulosa cells - Transcription regulation"	"Nucleoli, Endoplasmic reticulum"	"Cytokinetic bridge"	"HPA043261: AB_2630368, HPA043264: AB_2678398, HPA044028: AB_2678781"	"unprognostic (3.56e-1)"		"unprognostic (1.85e-1)"		"unprognostic (2.80e-1)"		"unprognostic (2.72e-2)"		"unprognostic (8.87e-2)"	"unprognostic (3.91e-2)"	"unprognostic (3.43e-2)"	"unprognostic (1.94e-1)"	"unprognostic (6.51e-2)"	"unprognostic (1.97e-2)"	"unprognostic (1.55e-1)"