Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific nTPM"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific nTPM"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific FPKM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific nTPM"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific nTPM"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific nTPM"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific nTPM"	"RNA tissue cell type enrichment"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific nTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific nTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Blood expression cluster"	"Tissue expression cluster"	"Cell line expression cluster"	"Single cell expression cluster"	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Pathology prognostics - Breast cancer"	"Pathology prognostics - Cervical cancer"	"Pathology prognostics - Colorectal cancer"	"Pathology prognostics - Endometrial cancer"	"Pathology prognostics - Glioma"	"Pathology prognostics - Head and neck cancer"	"Pathology prognostics - Liver cancer"	"Pathology prognostics - Lung cancer"	"Pathology prognostics - Melanoma"	"Pathology prognostics - Ovarian cancer"	"Pathology prognostics - Pancreatic cancer"	"Pathology prognostics - Prostate cancer"	"Pathology prognostics - Renal cancer"	"Pathology prognostics - Stomach cancer"	"Pathology prognostics - Testis cancer"	"Pathology prognostics - Thyroid cancer"	"Pathology prognostics - Urothelial cancer"
CNGA1	"CNCG, CNCG1, CNG1, RCNC1, RCNCa, RP49"	ENSG00000198515	"Cyclic nucleotide gated channel subunit alpha 1"	P29973	4	47935977-48016681	"Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels"	"Ion transport, Sensory transduction, Transport, Vision"	"Ion channel, Ligand-gated ion channel"	"Disease variant, Retinitis pigmentosa"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in many"	11	"retina: 264.4"	"Cell type enriched"	"Detected in many"	4	"Rod photoreceptor cells: 925.3"	"Cancer enhanced"	"Detected in many"		"urothelial cancer: 4.5"	"Low region specificity"	"Detected in some"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Low cancer specificity"	"Detected in many"			"Liver - Hepatocytes"	"Region enhanced"	"Detected in single"		"basal ganglia: 1.0"	"Not detected"	"Not detected"			HPA076168			Uncertain	"Nucleoplasm,Vesicles,Plasma membrane"		NA	NA			"Cluster 33: Neutrophils - Chromatin organization"	"Cluster 79: Retina - Phototransduction"	"Cluster 60: Keratinocytes - Epithelial cell function"	"Cluster 44: Photoreceptor cells - Visual perception"	"Nucleoplasm, Vesicles"	"Plasma membrane"	"HPA076168: AB_2686781"	"unprognostic (2.68e-2)"	"unprognostic (4.90e-2)"	"unprognostic (1.33e-1)"	"unprognostic (8.59e-2)"	"unprognostic (2.07e-1)"	"unprognostic (1.11e-2)"	"unprognostic (1.76e-2)"	"unprognostic (3.85e-2)"	"unprognostic (1.12e-1)"	"unprognostic (1.98e-2)"	"unprognostic (3.18e-1)"	"unprognostic (2.91e-1)"	"unprognostic (5.48e-6)"	"unprognostic (1.86e-1)"	"unprognostic (1.04e-1)"	"unprognostic (4.66e-2)"	"unprognostic (8.23e-2)"
CNGA2	"CNCA, CNCA1, CNG2, FLJ46312, OCNC1, OCNCa, OCNCALPHA"	ENSG00000183862	"Cyclic nucleotide gated channel subunit alpha 2"	Q16280	X	151738451-151745304	"Predicted membrane proteins, Voltage-gated ion channels"	"Ion transport, Olfaction, Sensory transduction, Transport"	"Calmodulin-binding, Ion channel, Ligand-gated ion channel"		"Evidence at transcript level"	"No human protein/transcript evidence"	"Evidence at transcript level"	"Evidence at transcript level"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Testis - Sertoli cells"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			HPA015065	Uncertain					NA	NA					"Cluster 7: Neuronal cell lines - Stereocilium"				"HPA015065: AB_1847034"																	
CNGA3	"ACHM2, CCNC1, CCNCa, CNCG3, CNG3"	ENSG00000144191	"Cyclic nucleotide gated channel subunit alpha 3"	Q16281	2	98346188-98398601	"Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels"	"Ion transport, Sensory transduction, Transport, Vision"	"Ion channel, Ligand-gated ion channel"	"Disease variant, Leber congenital amaurosis"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in some"		"brain: 5.7;intestine: 4.2;pituitary gland: 10.1;retina: 5.9"	"Cell type enriched"	"Detected in some"	11	"Cone photoreceptor cells: 34.5"	"Cancer enriched"	"Detected in some"	9	"glioma: 7.9"	"Low region specificity"	"Detected in many"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enriched"	"Detected in single"	7	"Neuroblastoma: 2.5"	"Lung - Respiratory ciliated cells, Pancreas - Alpha cells, Pancreas - Beta cells, Testis - Early spermatids"	"Group enriched"	"Detected in some"	6	"basal ganglia: 1.8;hypothalamus: 1.9"	"Not detected"	"Not detected"			"HPA049378, CAB079025"	Approved	Approved				NA	NA				"Cluster 77: Retina - Visual perception"	"Cluster 7: Neuronal cell lines - Stereocilium"	"Cluster 44: Photoreceptor cells - Visual perception"			"CAB079025: , HPA049378: AB_2732551"	"unprognostic (2.34e-2)"	"unprognostic (1.83e-2)"	"unprognostic (4.96e-2)"	"unprognostic (4.81e-2)"	"unprognostic (1.13e-1)"	"unprognostic (2.18e-1)"		"unprognostic (4.17e-4)"		"unprognostic (4.65e-2)"	"unprognostic (1.86e-3)"	"unprognostic (2.88e-1)"		"unprognostic (3.85e-3)"	"unprognostic (8.98e-2)"	"unprognostic (5.90e-2)"	"unprognostic (3.71e-2)"
CNGA4	"CNCA2, CNG5, CNGB2, OCNC2, OCNCb"	ENSG00000132259	"Cyclic nucleotide gated channel subunit alpha 4"	Q8IV77	11	6234765-6244479	"Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels"	"Ion transport, Olfaction, Sensory transduction, Transport"	"Ion channel, Ligand-gated ion channel"		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in some"		"fallopian tube: 17.3;testis: 6.1"	"Cell type enhanced"	"Detected in some"		"Astrocytes: 8.9;Early spermatids: 4.7;Endometrial ciliated cells: 2.7;Excitatory neurons: 3.0;Inhibitory neurons: 2.5;Late spermatids: 4.5;Oligodendrocytes: 2.9"	"Cancer enriched"	"Detected in single"	6	"endometrial cancer: 2.0"	"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Lung - Respiratory ciliated cells, Testis - Early spermatids, Testis - Late spermatids"	"Low region specificity"	"Detected in single"			"Not detected"	"Not detected"			HPA074128			Approved	"Nucleoplasm,Plasma membrane"		NA	NA			"Cluster 45: Eosinophils - Innate immune response"	"Cluster 42: Ciliated cells - Cilium & Cell projection"	"Cluster 41: Non-specific - Cilium assembly"	"Cluster 63: Astrocytes - Nervous system maintenance"	"Nucleoplasm, Plasma membrane"		"HPA074128: "	"unprognostic (1.11e-2)"	"unprognostic (4.32e-2)"	"unprognostic (2.69e-3)"	"prognostic favorable (1.48e-4)"	"unprognostic (4.96e-2)"	"unprognostic (1.09e-1)"	"unprognostic (2.01e-3)"	"unprognostic (1.89e-1)"	"unprognostic (8.51e-2)"	"unprognostic (5.51e-2)"	"unprognostic (1.83e-2)"	"unprognostic (8.70e-2)"	"unprognostic (1.03e-3)"	"unprognostic (3.84e-2)"	"unprognostic (3.47e-2)"	"unprognostic (8.11e-2)"	"unprognostic (3.55e-3)"
CNGB3	"ACHM1, ACHM3, RMCH"	ENSG00000170289	"Cyclic nucleotide gated channel subunit beta 3"	Q9NQW8	8	86553977-86743675	"Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels"	"Ion transport, Sensory transduction, Transport, Vision"	"Ion channel, Ligand-gated ion channel"	"Disease variant, Stargardt disease"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in some"		"bone marrow: 4.1;retina: 13.1"	"Cell type enriched"	"Detected in some"	22	"Cone photoreceptor cells: 253.3"	"Not detected"	"Not detected"			"Low region specificity"	"Detected in single"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Testis - Early spermatids"	"Not detected"	"Not detected"			"Not detected"	"Not detected"			HPA057244	Enhanced					NA	NA				"Cluster 77: Retina - Visual perception"	"Cluster 25: Non-specific - Basic cellular processes"	"Cluster 44: Photoreceptor cells - Visual perception"			"HPA057244: AB_2683380"	"unprognostic (5.35e-1)"	"unprognostic (1.68e-3)"	"unprognostic (1.22e-1)"	"unprognostic (2.42e-1)"	"unprognostic (3.62e-2)"	"unprognostic (2.58e-1)"	"unprognostic (6.25e-2)"	"unprognostic (1.18e-1)"	"unprognostic (2.91e-1)"	"unprognostic (2.17e-1)"	"unprognostic (3.82e-1)"	"unprognostic (9.28e-2)"	"unprognostic (2.77e-4)"	"unprognostic (1.40e-4)"	"unprognostic (1.66e-2)"	"unprognostic (8.76e-2)"	"unprognostic (1.84e-1)"
HCN1	"BCNG-1, BCNG1, HAC-2"	ENSG00000164588	"Hyperpolarization activated cyclic nucleotide gated potassium channel 1"	O60741	5	45254948-45696498	"Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels"	"Ion transport, Potassium transport, Sodium transport, Transport"	"Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel"	"Disease variant, Epilepsy"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Group enriched"	"Detected in some"	13	"brain: 7.2;retina: 17.6"	"Group enriched"	"Detected in some"	5	"Excitatory neurons: 662.5;Inhibitory neurons: 749.6;Rod photoreceptor cells: 201.2"	"Not detected"	"Not detected"			"Region enhanced"	"Detected in many"		"cerebral cortex: 7.2"	"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enhanced"	"Detected in single"		"Rhabdoid: 1.4"	"Colon - Colon enteroendocrine cells, Skeletal muscle - Skeletal myocytes, Skeletal muscle - Skeletal myocytes"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA019195	Enhanced					NA	NA				"Cluster 58: Brain - Synaptic function"	"Cluster 22: Rhabdoid cancers - Neuronal signaling"	"Cluster 37: Neurons - Neuronal signaling"			"HPA019195: AB_2670094"	"unprognostic (1.30e-1)"		"unprognostic (3.62e-1)"	"unprognostic (1.64e-1)"	"unprognostic (9.24e-3)"			"unprognostic (6.82e-2)"	"unprognostic (1.10e-1)"	"unprognostic (9.63e-3)"	"unprognostic (4.11e-3)"		"unprognostic (6.78e-2)"	"unprognostic (1.16e-2)"	"unprognostic (7.42e-2)"	"unprognostic (3.68e-3)"	
HCN2	"BCNG-2, BCNG2, HAC-1"	ENSG00000099822	"Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2"	Q9UL51	19	589881-617159	"Predicted membrane proteins, Transporters, Voltage-gated ion channels"	"Ion transport, Potassium transport, Sodium transport, Transport"	"Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel"	"Disease variant, Epilepsy"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in some"	11	"brain: 146.0"	"Cell type enhanced"	"Detected in some"		"Bipolar cells: 55.5;Excitatory neurons: 12.6;Horizontal cells: 28.2;Inhibitory neurons: 18.3;Oligodendrocytes: 58.6"	"Group enriched"	"Detected in many"	6	"glioma: 8.7;melanoma: 5.7;renal cancer: 2.8;testis cancer: 4.8"	"Low region specificity"	"Detected in all"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Low cancer specificity"	"Detected in many"			"Colon - Colon enteroendocrine cells, Heart muscle - Cardiomyocytes, Pancreas - Alpha cells, Skin - Eccrine sweat gland cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"									NA	NA				"Cluster 70: Brain - Nervous system development"	"Cluster 2: DU4475 - Unknown function"	"Cluster 35: Bipolar cells - Visual perception"				"unprognostic (8.69e-2)"	"unprognostic (3.97e-3)"	"unprognostic (3.31e-4)"	"unprognostic (1.44e-1)"	"unprognostic (2.44e-1)"	"unprognostic (3.07e-2)"	"unprognostic (1.57e-2)"	"unprognostic (1.97e-2)"	"unprognostic (1.55e-1)"	"unprognostic (5.32e-2)"	"unprognostic (1.19e-3)"	"unprognostic (8.00e-2)"	"prognostic unfavorable (6.99e-5)"	"unprognostic (1.07e-1)"	"unprognostic (1.41e-1)"	"unprognostic (5.53e-4)"	"unprognostic (9.72e-3)"
HCN3	KIAA1535	ENSG00000143630	"Hyperpolarization activated cyclic nucleotide gated potassium channel 3"	Q9P1Z3	1	155277463-155289848	"Metabolic proteins, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels"	"Ion transport, Potassium transport, Sodium transport, Transport"	"Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel"		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"liver: 14.7"	"Cell type enhanced"	"Detected in many"		"Inhibitory neurons: 9.2"	"Cancer enhanced"	"Detected in all"		"liver cancer: 10.0"	"Low region specificity"	"Detected in many"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Low cancer specificity"	"Detected in many"			"Liver - Hepatocytes"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA026584	Approved					NA	NA				"Cluster 18: Non-specific - Mitochondria"	"Cluster 21: Neuroblastoma - Neuronal signaling"	"Cluster 37: Neurons - Neuronal signaling"			"HPA026584: AB_1850534"	"unprognostic (1.04e-1)"	"unprognostic (6.22e-2)"	"unprognostic (7.17e-2)"	"unprognostic (1.34e-1)"	"unprognostic (3.17e-1)"	"unprognostic (1.48e-3)"	"unprognostic (1.63e-1)"	"unprognostic (5.97e-2)"	"unprognostic (4.44e-2)"	"unprognostic (1.84e-2)"	"unprognostic (4.36e-3)"	"unprognostic (1.33e-1)"	"prognostic unfavorable (7.49e-4)"	"unprognostic (2.55e-2)"	"unprognostic (1.85e-1)"	"unprognostic (5.90e-2)"	"prognostic favorable (6.93e-4)"
HCN4		ENSG00000138622	"Hyperpolarization activated cyclic nucleotide gated potassium channel 4"	Q9Y3Q4	15	73319859-73368958	"Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels"	"Ion transport, Potassium transport, Sodium transport, Transport"	"Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel"	"Brugada syndrome, Disease variant, Epilepsy"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Group enriched"	"Detected in some"	16	"brain: 8.5;heart muscle: 8.4;testis: 7.2"	"Group enriched"	"Detected in some"	4	"Early spermatids: 16.9;Late spermatids: 54.6"	"Cancer enriched"	"Detected in some"	4	"testis cancer: 3.1"	"Low region specificity"	"Detected in many"			"Not detected in immune cells"	"Not detected"			"Not detected"	"Not detected"			"Cancer enhanced"	"Detected in some"		"liver cancer: 1.6;testis cancer: 1.2"	"Lung - Respiratory ciliated cells, Testis - Late spermatids"	"Low region specificity"	"Detected in many"			"Low region specificity"	"Detected in many"			HPA073174	Approved					NA	NA				"Cluster 43: Testis - Unknown function"	"Cluster 41: Non-specific - Cilium assembly"	"Cluster 51: Late spermatids - Spermatogenesis"			"HPA073174: "	"unprognostic (2.21e-1)"	"unprognostic (1.39e-1)"	"unprognostic (2.18e-2)"	"unprognostic (3.14e-2)"	"unprognostic (5.30e-3)"	"unprognostic (1.92e-2)"	"unprognostic (2.19e-1)"	"unprognostic (3.50e-2)"	"unprognostic (2.37e-1)"	"unprognostic (6.56e-2)"	"unprognostic (1.13e-3)"	"unprognostic (1.13e-1)"	"unprognostic (6.05e-5)"	"unprognostic (5.56e-2)"	"unprognostic (4.60e-2)"	"unprognostic (1.51e-2)"	"unprognostic (7.95e-2)"