Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific nTPM"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific nTPM"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific FPKM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific nTPM"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific nTPM"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific nTPM"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific nTPM"	"RNA tissue cell type enrichment"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific nTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific nTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Blood expression cluster"	"Tissue expression cluster"	"Cell line expression cluster"	"Single cell expression cluster"	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Pathology prognostics - Breast cancer"	"Pathology prognostics - Cervical cancer"	"Pathology prognostics - Colorectal cancer"	"Pathology prognostics - Endometrial cancer"	"Pathology prognostics - Glioma"	"Pathology prognostics - Head and neck cancer"	"Pathology prognostics - Liver cancer"	"Pathology prognostics - Lung cancer"	"Pathology prognostics - Melanoma"	"Pathology prognostics - Ovarian cancer"	"Pathology prognostics - Pancreatic cancer"	"Pathology prognostics - Prostate cancer"	"Pathology prognostics - Renal cancer"	"Pathology prognostics - Stomach cancer"	"Pathology prognostics - Testis cancer"	"Pathology prognostics - Thyroid cancer"	"Pathology prognostics - Urothelial cancer"
GRN	"CLN11, PCDGF, PGRN"	ENSG00000030582	"Granulin precursor"	P28799	17	44345246-44353106	"Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins"		Cytokine	"Neurodegeneration, Neuronal ceroid lipofuscinosis"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Hofbauer cells: 1448.8"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Group enriched"	"Detected in all"	6	"classical monocyte: 2057.5;intermediate monocyte: 1122.4;myeloid DC: 1534.2;neutrophil: 851.2;non-classical monocyte: 548.1;plasmacytoid DC: 1331.9"	"Group enriched"	"Detected in all"	9	"dendritic cells: 1534.2;granulocytes: 851.2;monocytes: 2057.5"	"Low cancer specificity"	"Detected in all"			"Adipose subcutaneous - Macrophages, Adipose visceral - Macrophages, Colon - Macrophages, Lung - Macrophages, Stomach - Macrophages"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA008763, CAB019394, HPA028747"	Uncertain		Enhanced	Endosomes,Lysosomes	"Secreted to blood"	NA	NA	138000000	110000000	"Cluster 25: Monocytes - Inflammatory response"	"Cluster 75: Bone marrow - mRNA splicing & Cell cycle"	"Cluster 60: Keratinocytes - Epithelial cell function"	"Cluster 19: Macrophages - Innate immune response"	Lysosomes	Endosomes	"CAB019394: , HPA008763: AB_1850339, HPA028747: AB_10603767"	"unprognostic (1.84e-1)"	"unprognostic (2.34e-1)"	"unprognostic (8.38e-3)"	"unprognostic (2.82e-1)"	"prognostic unfavorable (8.78e-4)"	"unprognostic (7.41e-2)"	"unprognostic (3.53e-3)"	"unprognostic (3.57e-1)"	"unprognostic (1.63e-1)"	"unprognostic (2.40e-1)"	"unprognostic (2.24e-2)"	"unprognostic (1.52e-1)"	"unprognostic (6.34e-2)"	"unprognostic (2.54e-1)"	"unprognostic (1.43e-1)"	"unprognostic (1.43e-1)"	"unprognostic (1.62e-1)"
RPS6KC1	"humS6PKh1, RSKL1"	ENSG00000136643	"Ribosomal protein S6 kinase C1"	Q96S38	1	213051233-213274774	"Enzymes, Predicted intracellular proteins"		"Kinase, Serine/threonine-protein kinase, Transferase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Astrocytes: 83.5;Excitatory neurons: 269.3;Inhibitory neurons: 147.6;Microglial cells: 98.5;Oligodendrocyte precursor cells: 111.7;Oligodendrocytes: 129.9"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Immune cell enhanced"	"Detected in many"		"basophil: 16.8"	"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"				"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA026531, HPA031565"	Approved		Supported	Endosomes,Lysosomes		NA	NA			"Cluster 18: Basophils - Vesicular transport"	"Cluster 78: Testis - Spermatogenesis"	"Cluster 18: Non-specific - RNA binding"	"Cluster 38: Neurons - Neuronal signaling"	"Endosomes, Lysosomes"		"HPA026531: AB_10601497, HPA031565: AB_2673935"	"unprognostic (3.90e-2)"	"unprognostic (5.90e-2)"	"unprognostic (3.22e-1)"	"unprognostic (4.88e-2)"	"unprognostic (2.42e-1)"	"unprognostic (9.81e-2)"	"unprognostic (1.32e-2)"	"unprognostic (1.64e-1)"	"unprognostic (4.10e-2)"	"unprognostic (3.34e-1)"	"unprognostic (4.18e-1)"	"unprognostic (5.11e-2)"	"prognostic unfavorable (2.70e-4)"	"unprognostic (8.10e-2)"	"unprognostic (5.48e-2)"	"unprognostic (2.98e-2)"	"unprognostic (4.44e-2)"
SNX1	"HsT17379, MGC8664, SNX1A, Vps5"	ENSG00000028528	"Sorting nexin 1"	Q13596	15	64094123-64146090	"Predicted intracellular proteins"	"Protein transport, Transport"			"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Oligodendrocytes: 167.7"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Lung - Alveolar cells type 1, Thyroid - Thyroid glandular cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in single"			"HPA047373, HPA052761"	Approved		Enhanced	Endosomes,Lysosomes		NA	NA		6100000	"Cluster 31: Non-specific - Inflammatory response"	"Cluster 68: Epididymis - Unknown function"	"Cluster 45: Non-specific - Cell proliferation"	"Cluster 12: Non-specific - Chromatin organization"	"Endosomes, Lysosomes"		"HPA047373: AB_2680018, HPA052761: AB_2681939"	"unprognostic (3.99e-2)"	"unprognostic (8.65e-3)"	"unprognostic (1.96e-1)"	"unprognostic (1.50e-2)"	"unprognostic (7.13e-2)"	"unprognostic (2.73e-1)"	"unprognostic (7.15e-2)"	"unprognostic (6.49e-3)"	"unprognostic (1.53e-1)"	"unprognostic (8.28e-2)"	"unprognostic (2.47e-2)"	"unprognostic (3.26e-1)"	"prognostic favorable (9.88e-6)"	"unprognostic (2.27e-1)"	"unprognostic (3.98e-1)"	"unprognostic (2.59e-2)"	"unprognostic (1.95e-1)"
SNX2		ENSG00000205302	"Sorting nexin 2"	O60749	5	122775079-122834543	"Predicted intracellular proteins"	"Protein transport, Transport"			"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Extravillous trophoblasts: 275.7;Hofbauer cells: 338.8"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Immune cell enhanced"	"Detected in all"		"memory B-cell: 290.2;naive B-cell: 289.1"	"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Breast - Fibroblasts, Lung - Macrophages, Thyroid - Thyroid glandular cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA037400, HPA077664"	Approved		Enhanced	Endosomes,Lysosomes		NA	NA		150000	"Cluster 37: B-cells - Transcription"	"Cluster 72: Non-specific - Transcription"	"Cluster 57: Non-specific - Translation"	"Cluster 12: Non-specific - Chromatin organization"	Endosomes	Lysosomes	"HPA037400: AB_10670381, HPA077664: "	"unprognostic (9.26e-2)"	"unprognostic (1.14e-1)"	"unprognostic (1.86e-2)"	"unprognostic (1.97e-2)"	"unprognostic (2.74e-1)"	"unprognostic (2.91e-1)"	"prognostic unfavorable (7.90e-6)"	"unprognostic (1.03e-1)"	"unprognostic (3.86e-2)"	"unprognostic (3.27e-2)"	"unprognostic (4.41e-2)"	"unprognostic (1.60e-1)"	"prognostic favorable (8.76e-7)"	"unprognostic (8.76e-2)"	"unprognostic (1.01e-1)"	"unprognostic (1.07e-1)"	"unprognostic (8.59e-2)"
SNX6		ENSG00000129515	"Sorting nexin 6"	Q9UNH7	14	34561093-34630160	"Plasma proteins, Predicted intracellular proteins"	"Protein transport, Transport"			"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"				"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA049374	Approved		Supported	Endosomes,Lysosomes		NA	NA			"Cluster 31: Non-specific - Inflammatory response"	"Cluster 48: Parathyroid gland - membrane proteins"	"Cluster 46: Non-specific - Unknown function"	"Cluster 12: Non-specific - Chromatin organization"	"Endosomes, Lysosomes"		"HPA049374: AB_2680734"	"unprognostic (1.89e-1)"	"unprognostic (6.49e-2)"	"unprognostic (1.46e-1)"	"unprognostic (3.06e-2)"	"unprognostic (1.12e-1)"	"unprognostic (2.36e-3)"	"prognostic unfavorable (1.25e-4)"	"unprognostic (1.23e-1)"	"unprognostic (6.63e-2)"	"unprognostic (1.06e-1)"	"prognostic unfavorable (4.68e-4)"	"unprognostic (1.91e-1)"	"unprognostic (3.48e-2)"	"unprognostic (1.40e-1)"	"unprognostic (1.55e-1)"	"unprognostic (8.82e-2)"	"unprognostic (2.10e-2)"
TFRC	"CD71, p90, TFR1"	ENSG00000072274	"Transferrin receptor"	P02786	3	196027183-196082096	"Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters"	"Endocytosis, Host-virus interaction"	"Host cell receptor for virus entry, Receptor, Transducer"	"Cancer-related genes, Disease variant, FDA approved drug targets"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"bone marrow: 254.5"	"Cell type enhanced"	"Detected in many"		"Erythroid cells: 455.8;monocytes: 321.5;Syncytiotrophoblasts: 473.5"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"				"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB000153, HPA028598"	Enhanced		Supported	Endosomes,Lysosomes	"Secreted to blood"	NA	NA	1310000000	38000000	"Cluster 27: Non-specific - Gene expression"	"Cluster 40: Neutrophils - Inflammatory response"	"Cluster 44: Myeloma - Humoral immune response"	"Cluster 19: Macrophages - Innate immune response"	"Endosomes, Lysosomes"		"CAB000153: AB_2533029, HPA028598: AB_10601599"	"unprognostic (2.95e-2)"	"prognostic unfavorable (3.67e-4)"	"unprognostic (2.55e-1)"	"unprognostic (1.48e-2)"	"unprognostic (6.75e-2)"	"unprognostic (7.88e-3)"	"prognostic unfavorable (1.15e-4)"	"unprognostic (6.92e-2)"	"unprognostic (3.30e-3)"	"unprognostic (4.35e-2)"	"unprognostic (1.34e-2)"	"unprognostic (1.14e-2)"	"unprognostic (3.63e-3)"	"unprognostic (3.65e-2)"	"unprognostic (1.19e-2)"	"prognostic unfavorable (2.96e-4)"	"unprognostic (2.62e-2)"
TMEM106B	"FLJ11273, MGC33727"	ENSG00000106460	"Transmembrane protein 106B"	Q9NUM4	7	12211270-12243367	"Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters"	Transport		"Amyotrophic lateral sclerosis, Disease variant, Leukodystrophy, Neurodegeneration"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Thyroid - Thyroid glandular cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA058342	Approved		Supported	Endosomes,Lysosomes		NA	NA			"Cluster 27: Non-specific - Gene expression"	"Cluster 1: Thyroid gland - Transcription"	"Cluster 63: Non-specific - Unknown function"	"Cluster 53: Connective tissue cells - ECM organization"	"Endosomes, Lysosomes"		"HPA058342: AB_2683684"	"unprognostic (5.29e-2)"	"unprognostic (2.34e-2)"	"unprognostic (4.20e-2)"	"unprognostic (6.20e-2)"	"unprognostic (2.73e-1)"	"unprognostic (1.87e-2)"	"unprognostic (3.50e-2)"	"unprognostic (5.89e-2)"	"unprognostic (4.44e-2)"	"unprognostic (1.30e-1)"	"unprognostic (3.01e-3)"	"unprognostic (2.09e-2)"	"unprognostic (1.75e-3)"	"unprognostic (5.52e-2)"	"unprognostic (3.06e-2)"	"unprognostic (2.16e-2)"	"unprognostic (1.70e-1)"
VPS26A	"Hbeta58, PEP8A, VPS26"	ENSG00000122958	"VPS26, retromer complex component A"	O75436	10	69123512-69174412	"Plasma proteins, Predicted intracellular proteins, Transporters"	"Protein transport, Transport"			"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"Syncytiotrophoblasts: 259.1"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"				"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB011602, HPA057498, CAB075733"	Supported		Enhanced	Endosomes,Lysosomes		NA	NA		41000	"Cluster 7: Monocytes - Unknown function"	"Cluster 23: Testis - Cell cycle regulation"	"Cluster 67: Non-specific - Mitochondria & RNA binding"	"Cluster 67: Syncytiotrophoblasts - Pregnancy"	"Endosomes, Lysosomes"		"CAB011602: AB_2215043, CAB075733: AB_2665739, HPA057498: AB_2683448"	"unprognostic (1.17e-2)"	"unprognostic (6.94e-2)"	"unprognostic (5.58e-2)"	"unprognostic (9.35e-2)"	"unprognostic (5.95e-2)"	"prognostic unfavorable (1.72e-4)"	"prognostic unfavorable (1.70e-6)"	"unprognostic (1.17e-1)"	"unprognostic (1.35e-1)"	"unprognostic (7.88e-2)"	"prognostic unfavorable (9.18e-6)"	"unprognostic (4.63e-2)"	"unprognostic (2.15e-2)"	"unprognostic (7.14e-2)"	"unprognostic (6.68e-2)"	"unprognostic (4.33e-2)"	"unprognostic (1.72e-1)"
VPS35	"FLJ10752, MEM3, PARK17"	ENSG00000069329	"VPS35 retromer complex component"	Q96QK1	16	46656132-46689518	"Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters"	"Host-virus interaction, Protein transport, Transport"		"Neurodegeneration, Parkinson disease, Parkinsonism"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in many"			"Low lineage specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Thyroid - Thyroid glandular cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA040802	Supported		Supported	Endosomes,Lysosomes		NA	NA		500000	"Cluster 51: Monocytes - Innate immune response"	"Cluster 75: Bone marrow - mRNA splicing & Cell cycle"	"Cluster 23: B-cell cancers - Adaptive immune response"	"Cluster 17: Granulosa cells - Transcription regulation"	"Endosomes, Lysosomes"		"HPA040802: AB_2677142"	"unprognostic (1.11e-2)"	"unprognostic (8.70e-2)"	"prognostic favorable (7.74e-4)"	"unprognostic (4.75e-2)"	"unprognostic (1.90e-1)"	"unprognostic (5.67e-3)"	"prognostic unfavorable (2.10e-6)"	"unprognostic (5.32e-2)"	"unprognostic (1.49e-1)"	"unprognostic (2.29e-2)"	"unprognostic (3.33e-3)"	"unprognostic (2.49e-1)"	"prognostic favorable (9.75e-5)"	"unprognostic (3.68e-3)"	"unprognostic (2.43e-1)"	"unprognostic (1.34e-1)"	"unprognostic (6.89e-3)"