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ITPK1
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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:95.8 nTPM
HPA:95.8 nTPM
GTEx:176.4 nTPM
FANTOM5:97.9 Scaled Tags Per Million
Pig:23.1 nTPM
Mouse:38.2 nTPM
Allen mouse:3.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 95.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 89.7
2586 Male, age 75, left hemisphere 113.9
2666 Male, age 74, left hemisphere 97.9
2828 Female, age 72, unknown 94.0
2019 Male, age 18, unknown 92.9
1833 Male, age 53, unknown 87.2
1830 Male, age 51, unknown 86.9
1827 Male, age 72, unknown 84.5
1870 Female, age 42, unknown 84.1
2411 Female, age 72, unknown 82.3
2219 Male, age 76, both hemispheres 73.1
Dorsal raphe nucleus
nTPM: 77.8
2750 Male, age 76, both hemispheres 81.7
2016 Female, age 72, unknown 80.7
1828 Male, age 53, unknown 78.9
2047 Male, age 72, unknown 77.9
2298 Female, age 72, unknown 69.6
Inferior colliculus
nTPM: 77.2
1848 Female, age 42, unknown 83.9
1890 Male, age 53, unknown 78.2
2849 Male, age 72, unknown 76.9
2097 Female, age 72, unknown 70.0
Median raphe nucleus
nTPM: 70.3
2220 Male, age 76, midline 70.3
Pedunculopontine tegmental nucleus
nTPM: 73.0
2334 Male, age 80, both hemispheres 78.4
1921 Female, age 85, both hemispheres 75.7
2338 Male, age 61, both hemispheres 64.9
Periaquaductal grey, anterior
nTPM: 85.1
2502 Female, age 75, unknown 86.9
1947 Male, age 18, unknown 86.7
1795 Male, age 51, unknown 81.7
Periaquaductal grey, dorsal
nTPM: 74.6
1840 Male, age 53, unknown 76.7
2464 Female, age 72, unknown 76.2
1831 Male, age 72, unknown 76.0
2850 Male, age 76, both hemispheres 69.3
Periaquaductal grey, lateral
nTPM: 76.1
2053 Male, age 18, unknown 80.5
2140 Male, age 76, both hemispheres 76.4
2272 Male, age 74, both hemispheres 71.4
Pretectal area
nTPM: 87.3
2007 Male, age 72, unknown 102.6
1817 Female, age 42, unknown 96.6
1815 Male, age 53, unknown 95.9
2407 Male, age 75, both hemispheres 90.8
1816 Male, age 51, unknown 90.1
1944 Female, age 72, unknown 88.6
2316 Male, age 76, right hemisphere 88.6
2667 Female, age 75, unknown 85.8
2825 Male, age 18, unknown 78.8
2224 Female, age 72, unknown 72.7
2273 Male, age 74, both hemispheres 69.8
Red nucleus
nTPM: 95.8
2584 Male, age 75, left hemisphere 102.2
2785 Male, age 18, unknown 101.7
1904 Male, age 53, unknown 101.1
2503 Female, age 72, unknown 99.7
2588 Male, age 74, left hemisphere 99.2
2823 Male, age 76, right hemisphere 97.3
2769 Male, age 72, unknown 96.8
2227 Male, age 72, unknown 95.0
1865 Male, age 51, unknown 94.0
1821 Female, age 72, unknown 89.4
1954 Female, age 42, unknown 87.6
2725 Female, age 75, unknown 85.2
Substantia nigra
nTPM: 87.2
1889 Female, age 72, unknown 94.5
2583 Male, age 75, right hemisphere 93.6
1916 Female, age 42, unknown 92.4
1851 Male, age 51, unknown 91.7
2409 Female, age 72, unknown 89.0
2665 Male, age 74, both hemispheres 87.4
2590 Female, age 75, unknown 87.0
2699 Male, age 18, unknown 86.4
2241 Male, age 72, unknown 75.6
1941 Male, age 53, unknown 74.7
Superior colliculus
nTPM: 89.1
2664 Male, age 75, both hemispheres 104.5
2668 Female, age 75, unknown 97.9
1895 Male, age 76, right hemisphere 91.3
1796 Male, age 53, unknown 88.7
1995 Male, age 72, unknown 88.1
1839 Male, age 51, unknown 86.5
2087 Female, age 72, unknown 85.4
2587 Male, age 74, left hemisphere 84.4
1913 Female, age 42, unknown 82.5
2261 Male, age 18, unknown 81.5
Ventral tegmental area
nTPM: 81.8
2410 Female, age 72, unknown 91.0
1915 Female, age 42, unknown 83.9
1942 Male, age 51, unknown 82.1
2218 Male, age 76, both hemispheres 79.6
2021 Male, age 53, unknown 77.8
2223 Female, age 72, unknown 76.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 176.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 176.4
Samples: 139

Max nTPM: 323.9
Min nTPM: 87.7
Std nTPM: 42.2
Median nTPM: 168.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 323.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 297.5
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 277.2
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 271.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 261.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 261.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 259.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 254.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 249.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 249.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 245.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 243.6
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 243.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 243.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 240.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 232.5
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 232.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 230.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 226.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 222.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 222.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 221.2
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 220.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 218.9
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 214.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 214.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 213.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 211.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 210.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 209.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 208.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 207.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 203.8
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 200.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 198.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 197.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 197.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 195.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 195.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 193.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 193.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 192.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 191.9
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 190.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 190.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 188.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 187.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 186.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 185.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 181.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 180.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 180.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 179.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 178.0
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 176.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 176.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 175.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 174.3
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 174.2
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 174.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 173.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 172.7
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 172.6
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 172.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 172.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 170.4
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 169.7
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 169.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 168.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 168.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 167.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 167.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 165.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 165.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 164.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 163.7
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 162.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 162.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 161.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 161.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 160.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 160.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 160.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 159.9
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 159.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 159.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 158.8
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 158.8
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 158.5
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 158.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 157.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 157.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 155.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 154.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 154.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 154.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 153.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 153.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 152.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 151.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 151.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 150.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 149.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 149.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 149.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 148.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 146.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 146.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 145.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 143.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 142.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 141.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 140.5
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 140.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 139.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 138.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 138.3
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 138.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 137.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 136.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 136.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 136.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 136.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 135.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 134.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 133.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 128.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 125.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 124.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 124.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 120.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 114.6
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 114.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 113.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 109.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 104.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 101.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 99.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 87.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 97.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 97.9
FF:10158-103A5 76 years, female 97.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 23.1
Pig sample Sample description nTPM
Midbrain
nTPM: 20.4
Samples: 4

Max nTPM: 35.7
Min nTPM: 10.3
Sample A Female 10.3
Sample B Female 16.1
Sample C Male 35.7
Sample D Male 19.4
Periaqueductal gray
nTPM: 15.8
Samples: 3

Max nTPM: 19.9
Min nTPM: 12.8
Sample B Female 14.8
Sample C Male 19.9
Sample D Male 12.8
Substantia nigra
nTPM: 23.1
Samples: 4

Max nTPM: 30.8
Min nTPM: 10.7
Sample A Female 30.8
Sample B Female 21.7
Sample C Male 29.3
Sample D Male 10.7
Superior colliculi
nTPM: 23.1
Samples: 4

Max nTPM: 28.9
Min nTPM: 19.7
Sample A Female 22.3
Sample B Female 19.7
Sample C Male 28.9
Sample D Male 21.3

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 38.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 38.2
Samples: 4

Max nTPM: 44.3
Min nTPM: 32.9
Sample A Male 35.8
Sample B Male 32.9
Sample C Female 44.3
Sample D Female 39.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.0
71923998 Antisense, RP_051017_02_H03, Mouse strain C57BL/6J (56 days, male) 3.4
75694351 Antisense, RP_060518_03_F03, Mouse strain C57BL/6J (56 days, male) 2.6

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