The metabolic section - Explore the enzymes involved in human metabolism

The Metabolic section enables exploration of protein function and tissue-specific gene expression in the context of the most curated human metabolic network. For proteins involved in metabolism, a metabolic summary is provided that describes the metabolic subsystems/pathways, cellular compartments, and number of reactions associated with the protein. Over 120 manually curated metabolic pathway maps facilitate the visualization of each protein's participation in different metabolic processes. Each pathway map is accompanied by a heatmap detailing the mRNA levels across 256 different tissue types for all proteins involved in the metabolic pathway. More information about the human metabolic network, including how it was generated and what information it provides, can be found in the Methods summary.

Learn about:

  • what pathways/subsystems a metabolic gene is part of
  • which genes are nearby in the metabolic network
  • how the expression of the genes in a pathway/subsystem varies across different tissues


METABOLIC MAPS

Maps are organized by individual pathways to facilitate visualization of metabolic areas of interest. Further details and full cellular compartment maps are available at metabolicatlas.org.

Metabolic subsystem

Histidine metabolism

HAL
Pentose phosphate pathway

RBKS

Cellular compartment



Table 1. A complete list of the pathways details in the Metabolic Atlas and number of enzymes involved in each pathway.


Pathway # genes
Acyl-CoA hydrolysis 8
Acylglycerides metabolism 38
Alanine; aspartate and glutamate metabolism 40
Amino sugar and nucleotide sugar metabolism 32
Aminoacyl-tRNA biosynthesis 21
Androgen metabolism 23
Arachidonic acid metabolism 107
Arginine and proline metabolism 60
Ascorbate and aldarate metabolism 10
Beta oxidation of branched-chain fatty acids (mitochondrial) 10
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial) 16
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal) 11
Beta oxidation of even-chain fatty acids (mitochondrial) 13
Beta oxidation of even-chain fatty acids (peroxisomal) 9
Beta oxidation of odd-chain fatty acids (mitochondrial) 12
Beta oxidation of phytanic acid (peroxisomal) 24
Beta oxidation of poly-unsaturated fatty acids (mitochondrial) 11
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial) 14
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal) 9
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial) 14
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal) 9
Beta-alanine metabolism 21
Bile acid biosynthesis 96
Bile acid recycling 16
Biopterin metabolism 12
Biotin metabolism 4
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METABOLICATLAS.ORG

The metabolic features of the Metabolic Section are provided by metabolicatlas.org, which offers further detailed biochemical information on over 13,000 reactions, 8,000 metabolites, and 3,000 enzymes involved in human metabolism. Interactive 2D and 3D maps of the metabolic network are provided, and are organized by cellular compartment or metabolic subsystem to facilitate visualization of metabolic areas of interest. A global search functionality enables advanced filtering, and the same data is available through the API.