The structure section - Explore the protein structures of human proteins

The Structure section contains information about the three-dimensional structure of human proteins.The predicted 3D structure from the AlphaFold Protein Structure Database project is shown together with experimentally determined structures from the Protein Data Bank (PDB). All antigens with known sequence has been mapped and can be displayed on the protein structures. Additionally the amino acid positions of population variants and variants with known clinical relevance in the Ensembl variation database can be shown. More information about the specific content and the generation and analysis of the data in the section can be found in the Methods Summary.

Learn about:

the experimental and predicted 3D structure of proteins
the known missense variants with clinical significance
the known missense variants in the population
the antigen structure for the majority of the antibodies

EXPERIMENTAL STRUCTURES
View the structures of ALB in the Human Protein Atlas One of the experimental structures of the blood transport protein Albumin (PDB:1AO6) colored according to B-factor.

PREDICTED STRUCTURES
View the structures of ERBB2 in the Human Protein Atlas The predicted structure of the receptor tyrosine kinase ERBB2 (explore in AlphaFold Protein Structure Database) colored according to a per-residue confidence score (pLDDT) with dark blue representing the highest confidence and orange the lowest confidence.

CLINICAL VARIANTS
View the structures of ERBB2 in the Human Protein Atlas The predicted structure of the receptor tyrosine kinase ERBB2 (explore in AlphaFold Protein Structure Database) with variants classified as pathogenic or likely pathogenic in the clinical variants data set marked in red and variants present both in the clinical and the population variants sets marked in purple.

POPULATION VARIANTS
View the structures of ERBB2 in the Human Protein Atlas The predicted structure of the receptor tyrosine kinase ERBB2 (explore in AlphaFold Protein Structure Database) with population variants marked in blue and variants present both in the clinical and the population variants sets marked in purple .

ANTIGEN STRUCTURE
View the structures of ERBB2 in the Human Protein Atlas The predicted structure of the receptor tyrosine kinase ERBB2 (explore in AlphaFold Protein Structure Database) with the sequences of the antigens used to generate the antibodies displayed in red and blue.