Protein classes

The protein classes show a summary of genes identified in various protein classifications. Each row shows the total number of genes for a particular protein class as well as the number of those genes with experimental data in HPA for the corresponding proteins based on antibody-based profiling. All protein classes have been categorized into three different tables: "Function and compartment based", "Disease and drug related", and "Evidence based". Clicking one of the numbers in the tables retrieves a search result with the selection of genes belonging to the class, along with additional data. For each class, where applicable, there is also a link to the original source of the gene list. A number of classes contain a selection of subclasses which unfolds when the parent class (shown in bold and with arrows) is clicked. Some subclasses (marked with an asterisk) are not included in the total number of genes for the parent class.

Protein class No of genes No of genes
with antibodies

Function and compartment basedi

Enzymes 3706 3463
Metabolic proteins 3058 2841 Metabolic Atlas
CD markers 384 341 UniProt
Blood group antigen proteins 31 27 UniProt
Nuclear receptors 49 48 NucleaRDB
Transporters 1894 1686 TCDB
Ribosomal proteins 178 175 UniProt
G-protein coupled receptors 764 392 UniProt
Voltage-gated ion channels 132 108 IUPHAR-DB
Predicted membrane proteins 5543 4529 MDM
Predicted secreted proteins 1903 1465 HPA
Predicted intracellular proteins 15877 14195 HPA
Plasma proteins 3752 3562 Plasma Proteome Database
Transcription factors 1490 1375 UMG
RNA polymerase related proteins 31 31 KEGG
RAS pathway related proteins 231 208 KEGG
Citric acid cycle related proteins 30 29 KEGG
Immunoglobulin genes 214 49 Ensembl
T-cell receptor genes 195 0 Ensembl

Disease and drug relatedi

Cancer-related genes 1674 1589
Candidate cardiovascular disease genes 155 145 Plasma Proteome Institute
Disease related genes 4514 4205 UniProt
FDA approved drug targets 812 734 Drugbank
Potential drug targets 1575 1465 HPA
Human disease related genes 4085 3797 KEGG

Evidence basedi

Mapped to UniProt SWISS-PROT 19329 16971 UniProt
Mapped to neXtProt 19326 16971 neXtProt
Protein evidence (Kim et al 2014) 12308 11704 Kim et al 2014
Protein evidence (Ezkurdia et al 2014) 11725 11258 Ezkurdia et al 2014