In an article in PNAS HPA related researchers have used a combinatorial protein library to select binders against the overexpressed cancer receptor EGFR. The design of the scaffold protein allows for selection of both calcium -and pH dependency, an approach that can generate fine-tuned binders and possibly enable new treatment regimes...Read more

This year's Nobel Prize in Physiology and Medicine was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their discoveries concerning peripheral immune tolerance and regulatory T cells. These immune cells play an important role in protecting us from autoimmune diseases, and key to their development and function is the transcription factor FOXP3...Read more

At the 24th HUPO World Congress in Toronto, the theme "One Health Powered by Proteomics" emphasized the deep interconnectedness of humans, animals, microbes, and environments. In an article in Genetic Engineering and Biotechnology News, Gustav Ceder shares his impressions from this world congress together with thoughts and perspectives from some of the big players in the proteomics field...Read more

At the annual Human Proteome Organization (HUPO) meeting in Toronto, 25 HPA-affiliated members contributed more than 25 talks and posters across sessions. Among them was Loren Méar, researcher in the HPA and a postdoc working both in Pauliina Damdimopoulou's group at Karolinska Institutet and Cecilia Lindskog's lab at Uppsala University. Loren was selected as a poster competition finalist for her work "Spatial proteomics uncovers structural and molecular complexity of the human ovary in 2D and 3D."..Read more

This month, specific expression of Transmembrane protein 52B (gene: TMEM52B) in distal tubules in the kidney is highlighted with multiplex immunohistochemistry (mIHC/IF)...Read more