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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:40.1 nTPM
HPA:40.1 nTPM
GTEx:41.4 nTPM
FANTOM5:70.2 Scaled Tags Per Million
Pig:39.8 nTPM
Mouse:109.7 nTPM
Allen mouse:2.6 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 40.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 35.4
2411 Female, age 72, unknown 42.6
1870 Female, age 42, unknown 40.4
1833 Male, age 53, unknown 38.7
1830 Male, age 51, unknown 38.0
2019 Male, age 18, unknown 34.4
2828 Female, age 72, unknown 34.3
1827 Male, age 72, unknown 34.1
2586 Male, age 75, left hemisphere 31.8
2666 Male, age 74, left hemisphere 31.6
2219 Male, age 76, both hemispheres 28.0
Dorsal raphe nucleus
nTPM: 32.0
2298 Female, age 72, unknown 33.4
1828 Male, age 53, unknown 33.3
2750 Male, age 76, both hemispheres 32.8
2016 Female, age 72, unknown 31.0
2047 Male, age 72, unknown 29.6
Inferior colliculus
nTPM: 31.4
1848 Female, age 42, unknown 33.9
2097 Female, age 72, unknown 32.3
1890 Male, age 53, unknown 31.1
2849 Male, age 72, unknown 28.3
Median raphe nucleus
nTPM: 28.2
2220 Male, age 76, midline 28.2
Pedunculopontine tegmental nucleus
nTPM: 34.6
2338 Male, age 61, both hemispheres 40.0
2334 Male, age 80, both hemispheres 32.7
1921 Female, age 85, both hemispheres 31.0
Periaquaductal grey, anterior
nTPM: 33.6
1947 Male, age 18, unknown 41.5
2502 Female, age 75, unknown 32.2
1795 Male, age 51, unknown 27.0
Periaquaductal grey, dorsal
nTPM: 29.1
2464 Female, age 72, unknown 33.8
2850 Male, age 76, both hemispheres 28.6
1831 Male, age 72, unknown 28.0
1840 Male, age 53, unknown 26.2
Periaquaductal grey, lateral
nTPM: 29.4
2272 Male, age 74, both hemispheres 30.5
2053 Male, age 18, unknown 29.0
2140 Male, age 76, both hemispheres 28.6
Pretectal area
nTPM: 31.4
1944 Female, age 72, unknown 38.6
2667 Female, age 75, unknown 35.2
2273 Male, age 74, both hemispheres 33.9
1817 Female, age 42, unknown 32.9
1815 Male, age 53, unknown 32.4
1816 Male, age 51, unknown 31.0
2825 Male, age 18, unknown 30.5
2007 Male, age 72, unknown 29.4
2224 Female, age 72, unknown 28.4
2407 Male, age 75, both hemispheres 28.2
2316 Male, age 76, right hemisphere 24.6
Red nucleus
nTPM: 40.1
1821 Female, age 72, unknown 49.4
1865 Male, age 51, unknown 49.3
1954 Female, age 42, unknown 45.8
1904 Male, age 53, unknown 42.0
2769 Male, age 72, unknown 41.9
2503 Female, age 72, unknown 41.7
2227 Male, age 72, unknown 39.1
2823 Male, age 76, right hemisphere 38.1
2588 Male, age 74, left hemisphere 37.5
2725 Female, age 75, unknown 34.8
2785 Male, age 18, unknown 34.0
2584 Male, age 75, left hemisphere 27.2
Substantia nigra
nTPM: 36.3
2241 Male, age 72, unknown 39.9
2409 Female, age 72, unknown 39.7
1851 Male, age 51, unknown 38.0
1941 Male, age 53, unknown 37.4
2699 Male, age 18, unknown 37.1
1916 Female, age 42, unknown 36.9
2590 Female, age 75, unknown 35.7
2665 Male, age 74, both hemispheres 34.7
1889 Female, age 72, unknown 32.4
2583 Male, age 75, right hemisphere 30.9
Superior colliculus
nTPM: 33.9
1995 Male, age 72, unknown 39.6
2587 Male, age 74, left hemisphere 37.5
2087 Female, age 72, unknown 36.0
1913 Female, age 42, unknown 35.2
1895 Male, age 76, right hemisphere 34.7
2668 Female, age 75, unknown 34.2
1796 Male, age 53, unknown 33.7
2261 Male, age 18, unknown 31.5
1839 Male, age 51, unknown 30.7
2664 Male, age 75, both hemispheres 26.3
Ventral tegmental area
nTPM: 38.3
2410 Female, age 72, unknown 47.0
1915 Female, age 42, unknown 41.5
1942 Male, age 51, unknown 37.0
2223 Female, age 72, unknown 36.7
2218 Male, age 76, both hemispheres 35.5
2021 Male, age 53, unknown 32.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 41.4
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 41.4
Samples: 139

Max nTPM: 90.1
Min nTPM: 26.6
Std nTPM: 9.3
Median nTPM: 40.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 90.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 77.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 67.5
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 60.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 58.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 55.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 55.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 55.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 55.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 55.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 54.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 54.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 53.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 53.6
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 53.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 53.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 52.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 52.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 52.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 51.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 51.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 50.2
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 49.3
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 49.2
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 49.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 48.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 48.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 48.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 48.0
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 47.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 47.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 46.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 46.4
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 46.0
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 45.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 45.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 45.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 45.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 44.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 44.7
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 44.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 44.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 44.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 44.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 43.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 43.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 43.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 43.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 43.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 43.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 43.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 42.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 42.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 42.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 42.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 41.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 41.8
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 41.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 41.7
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 41.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 41.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 40.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 40.8
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 40.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 40.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 40.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 40.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 40.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 40.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 40.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 39.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 39.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 39.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 39.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 39.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 39.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 38.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 38.6
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 38.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 38.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 38.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 37.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 37.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 37.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 37.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 37.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 37.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 37.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 37.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 37.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 37.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 36.6
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 36.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 36.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 36.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 35.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 35.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 35.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 35.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 35.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 35.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 35.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 34.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 34.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 34.8
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 34.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 34.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 34.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 34.3
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 34.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 34.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 34.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 33.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 33.8
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 33.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 33.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 33.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 33.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 33.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 32.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 32.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 32.7
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 32.2
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 32.1
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 32.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 31.6
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 31.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 30.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 30.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 30.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 30.5
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 30.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 29.9
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 28.4
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 28.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 28.1
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 27.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 27.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 26.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 70.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 70.2
FF:10158-103A5 76 years, female 70.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 39.8
Pig sample Sample description nTPM
Midbrain
nTPM: 35.7
Samples: 4

Max nTPM: 44.8
Min nTPM: 22.7
Sample A Female 44.8
Sample B Female 38.0
Sample C Male 37.3
Sample D Male 22.7
Periaqueductal gray
nTPM: 26.2
Samples: 3

Max nTPM: 29.6
Min nTPM: 23.9
Sample B Female 29.6
Sample C Male 23.9
Sample D Male 25.0
Substantia nigra
nTPM: 35.4
Samples: 4

Max nTPM: 42.1
Min nTPM: 28.3
Sample A Female 42.1
Sample B Female 37.6
Sample C Male 28.3
Sample D Male 33.6
Superior colliculi
nTPM: 39.8
Samples: 4

Max nTPM: 48.1
Min nTPM: 33.1
Sample A Female 37.5
Sample B Female 48.1
Sample C Male 40.4
Sample D Male 33.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 109.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 109.7
Samples: 4

Max nTPM: 119.7
Min nTPM: 98.8
Sample A Male 98.8
Sample B Male 111.8
Sample C Female 119.7
Sample D Female 108.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.6
355886 Antisense, RP_040617_01_F04, Mouse strain C57BL/6J (56 days, male) 3.4
68269036 Antisense, RP_041208_01_E11, Mouse strain C57BL/6J (56 days, male) 1.9

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