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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
For selected proteins extended tissue profiling is performed in addition to standard tissue microarrays. The section below contains results from the extended profiling.
, antibody HPA042283
Glial cells
Not detected
Neuronal cells
High
Neuronal projections
Not detected
Synapses
Not detected
HYPOTHALAMUS - HPA Brain RNA-seq
Max nTPM
236.9
Sample id
Sample description
nTPM
Arcuate nucleus nTPM: 236.9
2226
Male, age 75, left hemisphere
372.6
1961
Female, age 42, unknown
101.2
Dorsomedial nucleus nTPM: 63.2
2041
Female, age 72, unknown
84.5
2017
Female, age 42, unknown
58.9
1989
Male, age 62, unknown
46.2
Lateral hypothalamic area nTPM: 122.0
2228
Male, age 66, unknown
207.4
1791
Male, age 80, right hemisphere
96.9
2271
Male, age 75, both hemispheres
96.8
2412
Male, age 62, unknown
87.0
Mamillary body nTPM: 27.0
1923
Female, age 72, unknown
43.0
2413
Male, age 66, unknown
39.0
1945
Male, age 80, right hemisphere
22.7
1948
Female, age 72, unknown
20.9
1834
Female, age 42, unknown
9.2
Paraventricular nucleus nTPM: 69.7
2700
Male, age 62, unknown
69.7
Preoptic area nTPM: 73.1
1907
Male, age 80, right hemisphere
128.6
1861
Female, age 42, unknown
45.9
2414
Female, age 72, unknown
44.9
Supraoptic nucleus nTPM: 58.3
2835
Female, age 72, unknown
86.1
1894
Female, age 72, unknown
45.2
2043
Male, age 62, unknown
43.5
HYPOTHALAMUS - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.
The Human Protein Atlas project is funded
