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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:62.0 nTPM
HPA:62.0 nTPM
GTEx:55.1 nTPM
FANTOM5:98.1 Scaled Tags Per Million
Pig:71.6 nTPM
Mouse:16.3 nTPM
Allen mouse:6.6 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 62.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 60.6
2586 Male, age 75, left hemisphere 103.2
2828 Female, age 72, unknown 68.5
2666 Male, age 74, left hemisphere 64.2
1870 Female, age 42, unknown 56.0
2019 Male, age 18, unknown 55.8
1827 Male, age 72, unknown 55.5
1830 Male, age 51, unknown 53.1
1833 Male, age 53, unknown 52.4
2219 Male, age 76, both hemispheres 50.1
2411 Female, age 72, unknown 47.2
Dorsal raphe nucleus
nTPM: 60.5
2047 Male, age 72, unknown 70.2
1828 Male, age 53, unknown 68.6
2016 Female, age 72, unknown 61.9
2298 Female, age 72, unknown 53.1
2750 Male, age 76, both hemispheres 48.5
Inferior colliculus
nTPM: 49.9
2849 Male, age 72, unknown 54.5
1890 Male, age 53, unknown 52.9
1848 Female, age 42, unknown 51.7
2097 Female, age 72, unknown 40.7
Median raphe nucleus
nTPM: 55.6
2220 Male, age 76, midline 55.6
Pedunculopontine tegmental nucleus
nTPM: 52.6
2338 Male, age 61, both hemispheres 60.3
2334 Male, age 80, both hemispheres 53.9
1921 Female, age 85, both hemispheres 43.7
Periaquaductal grey, anterior
nTPM: 51.9
1795 Male, age 51, unknown 57.4
1947 Male, age 18, unknown 51.3
2502 Female, age 75, unknown 47.1
Periaquaductal grey, dorsal
nTPM: 58.4
2850 Male, age 76, both hemispheres 71.5
1840 Male, age 53, unknown 58.7
1831 Male, age 72, unknown 54.3
2464 Female, age 72, unknown 49.1
Periaquaductal grey, lateral
nTPM: 62.0
2140 Male, age 76, both hemispheres 72.9
2053 Male, age 18, unknown 59.4
2272 Male, age 74, both hemispheres 53.6
Pretectal area
nTPM: 51.7
2407 Male, age 75, both hemispheres 63.1
2825 Male, age 18, unknown 59.1
1817 Female, age 42, unknown 52.1
2224 Female, age 72, unknown 52.1
2273 Male, age 74, both hemispheres 51.6
2316 Male, age 76, right hemisphere 51.3
1815 Male, age 53, unknown 49.7
2007 Male, age 72, unknown 49.5
2667 Female, age 75, unknown 47.2
1944 Female, age 72, unknown 47.0
1816 Male, age 51, unknown 45.8
Red nucleus
nTPM: 58.1
2584 Male, age 75, left hemisphere 77.4
2725 Female, age 75, unknown 65.6
2588 Male, age 74, left hemisphere 60.9
1865 Male, age 51, unknown 58.9
2823 Male, age 76, right hemisphere 57.4
1821 Female, age 72, unknown 55.5
2769 Male, age 72, unknown 55.5
1954 Female, age 42, unknown 55.3
2785 Male, age 18, unknown 54.1
2227 Male, age 72, unknown 53.6
2503 Female, age 72, unknown 51.8
1904 Male, age 53, unknown 51.2
Substantia nigra
nTPM: 54.8
2583 Male, age 75, right hemisphere 67.9
2699 Male, age 18, unknown 67.8
2665 Male, age 74, both hemispheres 61.1
1851 Male, age 51, unknown 55.0
1916 Female, age 42, unknown 54.3
1889 Female, age 72, unknown 52.5
2590 Female, age 75, unknown 51.8
2241 Male, age 72, unknown 49.6
1941 Male, age 53, unknown 48.3
2409 Female, age 72, unknown 39.7
Superior colliculus
nTPM: 53.2
2664 Male, age 75, both hemispheres 68.3
1995 Male, age 72, unknown 58.6
2668 Female, age 75, unknown 58.2
1796 Male, age 53, unknown 56.4
1839 Male, age 51, unknown 54.5
2587 Male, age 74, left hemisphere 52.8
1913 Female, age 42, unknown 50.9
2087 Female, age 72, unknown 47.3
2261 Male, age 18, unknown 43.2
1895 Male, age 76, right hemisphere 42.2
Ventral tegmental area
nTPM: 61.5
2223 Female, age 72, unknown 72.2
2021 Male, age 53, unknown 67.4
1942 Male, age 51, unknown 63.8
1915 Female, age 42, unknown 63.4
2218 Male, age 76, both hemispheres 52.6
2410 Female, age 72, unknown 49.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 55.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 55.1
Samples: 139

Max nTPM: 129.5
Min nTPM: 21.3
Std nTPM: 16.3
Median nTPM: 52.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 129.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 124.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 103.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 96.2
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 87.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 86.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 85.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 81.5
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 80.1
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 77.8
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 77.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 75.0
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 74.7
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 74.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 73.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 72.8
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 72.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 71.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 71.1
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 70.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 69.8
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 68.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 67.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 67.6
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 66.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 65.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 65.3
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 64.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 64.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 64.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 64.3
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 63.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 63.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 63.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 62.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 62.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 61.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 61.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 61.4
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 61.2
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 60.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 60.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 60.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 58.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 58.9
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 58.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 58.7
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 58.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 58.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 57.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 57.8
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 57.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 57.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 57.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 57.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 57.2
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 56.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 56.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 55.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 54.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 54.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 54.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 53.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 53.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 53.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 53.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 53.0
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 52.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 52.6
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 52.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 52.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 52.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 52.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 51.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 51.1
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 50.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 50.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 50.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 50.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 50.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 50.3
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 50.2
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 50.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 50.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 49.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 49.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 49.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 49.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 49.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 48.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 48.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 48.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 48.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 47.8
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 47.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 47.5
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 47.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 46.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 46.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 46.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 46.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 46.1
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 46.1
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 45.5
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 44.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 43.9
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 43.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 43.0
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 42.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 42.8
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 42.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 42.3
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 41.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 40.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 40.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 40.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 40.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 40.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 39.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 39.4
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 39.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 39.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 38.6
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 38.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 38.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 37.5
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 37.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 36.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 36.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 35.4
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 34.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 34.4
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 33.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 33.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 32.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 32.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 31.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 28.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 21.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 98.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 98.1
FF:10158-103A5 76 years, female 98.1

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 71.6
Pig sample Sample description nTPM
Midbrain
nTPM: 64.7
Samples: 4

Max nTPM: 117.9
Min nTPM: 42.7
Sample A Female 117.9
Sample B Female 50.5
Sample C Male 47.7
Sample D Male 42.7
Periaqueductal gray
nTPM: 53.8
Samples: 3

Max nTPM: 62.5
Min nTPM: 48.8
Sample B Female 48.8
Sample C Male 62.5
Sample D Male 50.0
Substantia nigra
nTPM: 71.6
Samples: 4

Max nTPM: 77.2
Min nTPM: 66.4
Sample A Female 76.2
Sample B Female 66.7
Sample C Male 66.4
Sample D Male 77.2
Superior colliculi
nTPM: 58.1
Samples: 4

Max nTPM: 67.2
Min nTPM: 51.6
Sample A Female 67.2
Sample B Female 55.4
Sample C Male 51.6
Sample D Male 58.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 16.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 16.3
Samples: 4

Max nTPM: 17.1
Min nTPM: 15.1
Sample A Male 15.1
Sample B Male 16.9
Sample C Female 17.1
Sample D Female 16.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 6.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 6.6
69262288 Antisense, RP_050303_01_F05, Mouse strain C57BL/6J (56 days, male) 6.6

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