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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:4.3 nTPM
HPA:4.3 nTPM
GTEx:33.2 nTPM
FANTOM5:132.5 Scaled Tags Per Million
Pig:125.6 nTPM
Mouse:46.5 nTPM
Allen mouse:16.4 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 4.3
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 0.9
2219 Male, age 76, both hemispheres 5.9
2019 Male, age 18, unknown 3.0
1830 Male, age 51, unknown 0.8
1827 Male, age 72, unknown 0.0
1833 Male, age 53, unknown 0.0
1870 Female, age 42, unknown 0.0
2411 Female, age 72, unknown 0.0
2586 Male, age 75, left hemisphere 0.0
2666 Male, age 74, left hemisphere 0.0
2828 Female, age 72, unknown 0.0
Dorsal raphe nucleus
nTPM: 0.0
1828 Male, age 53, unknown 0.0
2016 Female, age 72, unknown 0.0
2047 Male, age 72, unknown 0.0
2298 Female, age 72, unknown 0.0
2750 Male, age 76, both hemispheres 0.0
Inferior colliculus
nTPM: 0.0
1848 Female, age 42, unknown 0.0
1890 Male, age 53, unknown 0.0
2097 Female, age 72, unknown 0.0
2849 Male, age 72, unknown 0.0
Median raphe nucleus
nTPM: 0.0
2220 Male, age 76, midline 0.0
Pedunculopontine tegmental nucleus
nTPM: 0.2
1921 Female, age 85, both hemispheres 0.6
2334 Male, age 80, both hemispheres 0.0
2338 Male, age 61, both hemispheres 0.0
Periaquaductal grey, anterior
nTPM: 0.0
1795 Male, age 51, unknown 0.0
1947 Male, age 18, unknown 0.0
2502 Female, age 75, unknown 0.0
Periaquaductal grey, dorsal
nTPM: 0.0
1831 Male, age 72, unknown 0.0
1840 Male, age 53, unknown 0.0
2464 Female, age 72, unknown 0.0
2850 Male, age 76, both hemispheres 0.0
Periaquaductal grey, lateral
nTPM: 0.0
2053 Male, age 18, unknown 0.0
2140 Male, age 76, both hemispheres 0.0
2272 Male, age 74, both hemispheres 0.0
Pretectal area
nTPM: 1.4
1944 Female, age 72, unknown 5.4
1816 Male, age 51, unknown 3.0
2407 Male, age 75, both hemispheres 2.2
1815 Male, age 53, unknown 1.7
2667 Female, age 75, unknown 1.6
2007 Male, age 72, unknown 1.5
1817 Female, age 42, unknown 0.0
2224 Female, age 72, unknown 0.0
2273 Male, age 74, both hemispheres 0.0
2316 Male, age 76, right hemisphere 0.0
2825 Male, age 18, unknown 0.0
Red nucleus
nTPM: 0.1
2584 Male, age 75, left hemisphere 1.3
1821 Female, age 72, unknown 0.0
1865 Male, age 51, unknown 0.0
1904 Male, age 53, unknown 0.0
1954 Female, age 42, unknown 0.0
2227 Male, age 72, unknown 0.0
2503 Female, age 72, unknown 0.0
2588 Male, age 74, left hemisphere 0.0
2725 Female, age 75, unknown 0.0
2769 Male, age 72, unknown 0.0
2785 Male, age 18, unknown 0.0
2823 Male, age 76, right hemisphere 0.0
Substantia nigra
nTPM: 4.3
2409 Female, age 72, unknown 13.3
1941 Male, age 53, unknown 8.4
1916 Female, age 42, unknown 6.5
2590 Female, age 75, unknown 6.2
2241 Male, age 72, unknown 5.9
2583 Male, age 75, right hemisphere 1.4
2699 Male, age 18, unknown 1.4
1851 Male, age 51, unknown 0.0
1889 Female, age 72, unknown 0.0
2665 Male, age 74, both hemispheres 0.0
Superior colliculus
nTPM: 0.3
2087 Female, age 72, unknown 3.4
1796 Male, age 53, unknown 0.0
1839 Male, age 51, unknown 0.0
1895 Male, age 76, right hemisphere 0.0
1913 Female, age 42, unknown 0.0
1995 Male, age 72, unknown 0.0
2261 Male, age 18, unknown 0.0
2587 Male, age 74, left hemisphere 0.0
2664 Male, age 75, both hemispheres 0.0
2668 Female, age 75, unknown 0.0
Ventral tegmental area
nTPM: 1.9
2218 Male, age 76, both hemispheres 4.5
2410 Female, age 72, unknown 3.8
2223 Female, age 72, unknown 2.3
1915 Female, age 42, unknown 0.7
1942 Male, age 51, unknown 0.0
2021 Male, age 53, unknown 0.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 33.2
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 33.2
Samples: 139

Max nTPM: 70.2
Min nTPM: 14.5
Std nTPM: 10.6
Median nTPM: 31.1
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 70.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 68.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 60.9
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 60.0
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 59.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 57.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 53.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 53.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 52.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 51.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 50.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 48.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 46.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 46.5
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 46.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 45.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 45.3
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 45.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 44.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 44.0
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 43.7
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 43.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 43.3
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 43.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 42.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 42.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 41.5
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 40.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 40.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 39.8
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 39.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 39.3
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 39.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 39.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 38.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 38.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 38.4
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 38.4
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 38.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 38.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 38.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 37.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 37.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 37.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 36.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 36.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 36.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 36.1
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 35.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 35.3
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 35.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 35.1
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 35.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 34.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 33.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 33.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 33.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 33.1
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 32.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 32.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 32.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 32.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 32.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 31.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 31.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 31.7
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 31.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 31.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 31.1
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 31.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 31.0
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 31.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 30.9
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 30.7
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 30.3
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 30.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 30.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 30.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 29.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 29.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 29.6
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 29.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 29.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 29.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 29.4
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 29.4
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 29.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 28.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 28.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 28.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 28.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 28.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 28.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 27.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 27.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 27.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 27.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 26.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 26.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 26.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 26.3
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 26.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 26.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 26.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 25.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 25.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 25.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 25.6
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 25.5
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 25.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 25.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 25.1
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 24.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 24.4
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 24.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 23.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 23.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 23.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 23.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 22.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 22.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 22.5
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 21.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 21.8
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 21.4
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 21.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 20.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 20.8
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 20.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 20.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 19.7
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 19.5
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 18.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 17.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 16.7
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 16.5
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 15.7
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 15.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 14.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 132.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 132.5
FF:10158-103A5 76 years, female 132.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 125.6
Pig sample Sample description nTPM
Midbrain
nTPM: 125.6
Samples: 4

Max nTPM: 184.1
Min nTPM: 86.4
Sample A Female 133.9
Sample B Female 86.4
Sample C Male 184.1
Sample D Male 97.9
Periaqueductal gray
nTPM: 75.7
Samples: 3

Max nTPM: 84.3
Min nTPM: 65.5
Sample B Female 77.3
Sample C Male 84.3
Sample D Male 65.5
Substantia nigra
nTPM: 118.3
Samples: 4

Max nTPM: 149.2
Min nTPM: 87.7
Sample A Female 149.2
Sample B Female 87.7
Sample C Male 132.9
Sample D Male 103.5
Superior colliculi
nTPM: 119.6
Samples: 4

Max nTPM: 160.2
Min nTPM: 81.7
Sample A Female 114.7
Sample B Female 81.7
Sample C Male 160.2
Sample D Male 121.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 46.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 46.5
Samples: 4

Max nTPM: 52.3
Min nTPM: 33.1
Sample A Male 33.1
Sample B Male 50.3
Sample C Female 50.3
Sample D Female 52.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 16.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 16.4
69627003 Antisense, RP_050428_01_F11, Mouse strain C57BL/6J (56 days, male) 16.4

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