Protein 3D structures
The structure of a protein gives valuable clues of its interaction with other molecules and thereby important information of its functions. For the majority of the proteins in the Human Protein Atlas a predicted 3D structure from the AlphaFold Protein Structure Database project is shown together with experimentally determined structures from the Protein Data Bank (PDB). The structures can be explored and antigens corresponding to many of the antibodies in the Atlas, as well as clinical -and population variants, can be displayed on the structures.
Key publications- Jumper J et al., Highly accurate protein structure prediction with AlphaFold. Nature. (2021) - Varadi M et al., AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Res. (2022) - Berman HM et al., The Protein Data Bank. Nucleic Acids Res. (2000)
Key facts
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