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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.
Cytoplasmic staining in proximal tubules. Additional staining in collecting ducts and distal tubules.
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Antibody localization in the annotated cell types/states of the current human tissue is reported as main/additional locations, percent overlap between the antibody and cell type/state-specific markers, and subcellular location. The scores are based on multiplex immunohistochemistry profiling in selected tissues.
Main locations are characterized by a high overlap between the antibody and the cell type/state-specific marker combined with strong antibody signal intensity,
while additional locations are characterized by lower overlap and weaker antibody signal intensity.
The antibody of interest is reported in green, while cell types/states are reported in various other colors, and DAPI (marks nucleus) is reported in blue. Colors can be toggled on and off by clicking on the name of the cell type/state of interest, “Antibody” or “DAPI”. To toggle between the different tissue samples, click on the miniature images at the right bottom corner of the main image. The miniature images appear upon hovering the mouse over that area.
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.
Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max nTPM: 118.7
Min nTPM: 6.7
Std nTPM: 20.6
Median nTPM: 25.6
GTEX-T6MN-1826-SM-EXOHN
50-59 years, male
118.7
GTEX-13NYB-1726-SM-5N9G2
40-49 years, male
112.5
GTEX-14E6D-2526-SM-5YYA9
50-59 years, male
92.5
GTEX-1JMQJ-1726-SM-E9U4V
50-59 years, male
90.0
GTEX-17HHY-2326-SM-7KFSR
50-59 years, male
72.6
GTEX-1KWVE-0826-SM-CXZKO
30-39 years, male
63.9
GTEX-1NV8Z-2226-SM-EXOJ2
60-69 years, male
60.8
GTEX-11OF3-1326-SM-5N9FJ
60-69 years, male
57.5
GTEX-14C5O-2026-SM-5YYB1
60-69 years, male
51.6
GTEX-1JMPZ-1226-SM-ARU8Y
30-39 years, male
50.2
GTEX-13OW6-1826-SM-5N9F9
50-59 years, male
48.2
GTEX-1R9PO-1626-SM-E6CPT
60-69 years, female
48.2
GTEX-1K9T9-1826-SM-CXZK2
50-59 years, female
42.0
GTEX-REY6-1826-SM-EAZAT
60-69 years, male
41.6
GTEX-15CHQ-2126-SM-6871M
60-69 years, male
40.6
GTEX-1IKK5-0926-SM-A9G2U
60-69 years, male
39.2
GTEX-1HB9E-1826-SM-D4P33
50-59 years, male
39.0
GTEX-Y5V6-2026-SM-5IFHO
60-69 years, male
38.3
GTEX-15DYW-2026-SM-6AJBD
60-69 years, female
38.1
GTEX-16MT8-1926-SM-7EPGL
60-69 years, female
37.9
GTEX-1GF9W-1326-SM-7P8PX
60-69 years, male
37.3
GTEX-1GF9V-1926-SM-9JGHE
60-69 years, male
37.0
GTEX-QDT8-1726-SM-EYYV6
30-39 years, female
36.4
GTEX-1497J-0826-SM-5NQAJ
60-69 years, male
36.3
GTEX-1GTWX-1826-SM-9QEHG
60-69 years, male
36.0
GTEX-S33H-1426-SM-EZ6L7
30-39 years, male
35.4
GTEX-1GMR3-2426-SM-7MXV2
40-49 years, male
34.8
GTEX-1BAJH-1826-SM-731DA
70-79 years, male
34.0
GTEX-1H3NZ-2126-SM-9WPQ6
60-69 years, male
32.6
GTEX-1EKGG-2226-SM-7IGOA
60-69 years, male
31.9
GTEX-T5JC-1526-SM-4DM68
20-29 years, male
31.9
GTEX-XPVG-0526-SM-4B65N
50-59 years, male
31.5
GTEX-Y5V5-1226-SM-EYYVP
60-69 years, female
31.5
GTEX-1A8FM-2026-SM-7P8RN
50-59 years, female
30.8
GTEX-1JJ6O-2526-SM-AHZ3J
60-69 years, male
28.2
GTEX-1AX8Z-2326-SM-731CR
60-69 years, male
27.6
GTEX-1I1GP-1926-SM-CNNQU
50-59 years, male
27.6
GTEX-1N2EF-1426-SM-EXUSH
60-69 years, male
27.5
GTEX-1IL2V-1826-SM-ARU7R
70-79 years, male
27.1
GTEX-O5YV-1226-SM-EV795
60-69 years, female
26.6
GTEX-1J1OQ-1426-SM-AHZ3P
40-49 years, female
26.5
GTEX-ZC5H-1726-SM-5HL7X
40-49 years, female
26.1
GTEX-P4QS-1126-SM-3NMD5
60-69 years, male
25.6
GTEX-17F96-1926-SM-7MGWY
70-79 years, male
25.5
GTEX-14C39-2126-SM-664OH
40-49 years, male
25.3
GTEX-1JMQK-1926-SM-CJI3B
60-69 years, male
25.0
GTEX-ZDXO-0226-SM-4WKH7
60-69 years, male
24.9
GTEX-1HCU7-1826-SM-A9G2A
50-59 years, male
24.8
GTEX-145MN-0326-SM-5QGQI
30-39 years, male
24.7
GTEX-1C6VQ-2326-SM-7IGN1
50-59 years, male
24.7
GTEX-QDVN-1626-SM-48TZC
50-59 years, male
24.4
GTEX-1QP6S-1526-SM-EXUSG
40-49 years, male
24.2
GTEX-1HBPI-2026-SM-CE6RZ
50-59 years, male
23.9
GTEX-1E2YA-1626-SM-7MGXS
50-59 years, male
23.4
GTEX-13O1R-2526-SM-5N9FW
60-69 years, male
23.0
GTEX-QLQW-1626-SM-CMKFE
30-39 years, male
22.3
GTEX-13OVL-1826-SM-5KLZR
50-59 years, male
21.6
GTEX-12WSG-0826-SM-5EQ5A
50-59 years, female
21.5
GTEX-11GS4-2326-SM-5A5KS
60-69 years, male
21.0
GTEX-1PWST-2226-SM-EVR3G
70-79 years, male
20.9
GTEX-1JMLX-1526-SM-AHZ3N
50-59 years, male
20.2
GTEX-1F48J-2226-SM-7MXTN
50-59 years, female
19.9
GTEX-1CB4J-1926-SM-7MGX8
60-69 years, male
19.8
GTEX-13RTJ-2226-SM-5S2Q1
60-69 years, male
18.6
GTEX-ZYT6-2226-SM-5GIC9
30-39 years, male
18.5
GTEX-1H3VY-1926-SM-9JGHJ
50-59 years, male
18.2
GTEX-NPJ8-2226-SM-3TW8D
40-49 years, male
18.1
GTEX-1LG7Y-2726-SM-D5OVW
50-59 years, male
18.1
GTEX-ZYFG-1626-SM-5GZYY
60-69 years, female
17.4
GTEX-1GN1U-2126-SM-AHZ4J
50-59 years, female
17.2
GTEX-17F97-1926-SM-7IGM4
50-59 years, male
15.9
GTEX-1MUQO-2526-SM-E9TJN
60-69 years, male
15.5
GTEX-1N2DW-1826-SM-EAZ54
50-59 years, male
15.2
GTEX-12696-0926-SM-5FQTV
60-69 years, male
14.7
GTEX-1OJC4-2326-SM-DTXA5
50-59 years, female
13.9
GTEX-13112-2126-SM-5GCO4
50-59 years, male
13.8
GTEX-13OVI-1126-SM-5KLZF
60-69 years, female
13.5
GTEX-147F4-2626-SM-5Q5CS
50-59 years, male
13.1
GTEX-ZVZP-0926-SM-5GIDB
50-59 years, male
12.7
GTEX-ZLFU-0926-SM-5P9F8
40-49 years, male
12.5
GTEX-1A3MW-2226-SM-73KUX
60-69 years, female
11.3
GTEX-ZE9C-1426-SM-4WKGM
60-69 years, male
10.9
GTEX-1399S-0526-SM-5IJG8
30-39 years, female
8.7
GTEX-RN64-1626-SM-48FD7
50-59 years, male
8.5
GTEX-11TTK-1926-SM-5PNW8
60-69 years, female
6.7
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Kidney - Medulla Average nTPM: 18.9
Samples: 4
Max nTPM: 34.4
Min nTPM: 10.9
Std nTPM: 9.5
Median nTPM: 15.1
GTEX-RU72-1926-SM-EAZ3F
50-59 years, female
34.4
GTEX-TKQ2-0626-SM-EZ6LB
50-59 years, male
19.2
GTEX-R55E-2026-SM-EZ6L1
20-29 years, male
11.0
GTEX-T5JC-1626-SM-EZ6KW
20-29 years, male
10.9
KIDNEY - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.