Immune cell expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in. Read more	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function. Read more	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Neutrophils	Mixed function	333	Medium
2	Granulocytes	Unknown function	239	Medium
3	Plasmacytoid DCs	Unknown function	367	Medium
4	T-regs	Cell cycle regulation	321	Medium
5	Granulocytes	Unknown function	263	Low
6	Non-specific	Transcription	224	Medium
7	Monocytes	Unknown function	353	Medium
8	Neutrophils	Inflammatory response	501	High
9	Neutrophils	Innate immune response	318	High
10	Basophils	Unknown function	224	Low
11	Basophils	Unknown function	166	Low
12	Non-specific	Basic cellular processes	711	Medium
13	T-cells	Unknown function	58	Medium
14	Monocytes	Unknown function	289	Low
15	NK-cells	Transcription	429	Low
16	MAIT-cells	Unknown function	309	Medium
17	Basophils	Unknown function	232	Low
18	Basophils	Vesicular transport	175	Low
19	B-cells	Humoral immune response	192	High
20	T-cells	T-cell receptor	245	High
21	B-cells	Adaptive immune response	241	High
22	NK-cells	Unknown function	130	Very low
23	Antigen presenting cells	Antigen presentation	91	High
24	B-cells	Unknown function	221	Very low
25	Monocytes	Inflammatory response	307	High
26	Non-specific	Mitochondria	214	Very low
27	Non-specific	Gene expression	649	Medium
28	Myeloid DCs	Unknown function	247	Medium
29	Plasmacytoid DCs	Unknown function	82	Very low
30	Non-specific	Translation	193	High
31	Non-specific	Inflammatory response	368	Low
32	T-cells	Unknown function	335	Medium
33	Neutrophils	Chromatin organization	174	Very low
34	Basophils	Unknown function	261	Low
35	T-regs	Unknown function	278	Low
36	GdT-cells	Adaptive immune response	324	High
37	B-cells	Transcription	291	Medium
38	Basophils	Unknown function	306	High
39	Non-specific	mRNA processing	270	Medium
40	NK-cells	Unknown function	161	Very low
41	Basophils	Cellular respiration	260	Low
42	Non-specific	Transcription	77	Low
43	B-cells	Humoral immune response	204	High
44	Non-specific	Transcription	403	Medium
45	Eosinophils	Innate immune response	561	High
46	Basophils	DNA binding	341	Medium
47	Plasmacytoid DCs	Protein folding	376	Low
48	NK-cells	Unknown function	282	Medium
49	Eosinophils	Unknown function	225	Low
50	Neutrophils	Cellular senescence	129	Medium
51	Monocytes	Innate immune response	245	High
52	Eosinophils	Transcription	439	Medium

The interactive UMAP plot displays the 52 gene clusters resulting from Louvain clustering of gene expression across all immune cell types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all immune cell type samples for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.