Single cell type expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in. Read more	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function. Read more	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	T-cells	Immune response	378	High
2	T-cells	T-cell receptor	243	Medium
3	Suprabasal keratinocytes	Cornification	185	High
4	Platelets	Platelet activation	157	High
5	Bronchus	Unknown function	208	Low
6	Late spermatids	Spermatogenesis	433	Medium
7	NK-cells	Immune response regulation	312	Medium
8	Oligodendrocytes	Myelin sheath organization	301	Medium
9	Neurons	Nervous system development	235	Medium
10	Neurons & Oligodendrocytes	Nervous system development	262	High
11	Non-specific	Transcription	188	Medium
12	Non-specific	Chromatin organization	249	Low
13	Hepatocytes	Oxidoreductase activity	177	High
14	Endometrium	Transcription regulation	304	Low
15	Smooth muscle cells	Muscle contraction	246	High
16	Non-specific	RNA binding	751	Low
17	Granulosa cells	Transcription regulation	353	Medium
18	Non-specific	Mixed function	294	Low
19	Macrophages	Innate immune response	247	High
20	Airway & Pancreas	Proteolysis	48	Medium
21	Serous glandular cells	Salivary secretion	134	Medium
22	Squamous epithelial cells	Keratinization	298	High
23	Langerhans cells	Immune response	91	Medium
24	Spermatids	Unknown function	117	Low
25	Schwann cells & Melanocytes	Mixed function	80	Low
26	Intestinal epithelial cells	Absorption	271	High
27	Skeletal myocytes	Muscle contraction	105	High
28	Cytotrophoblasts	Unknown function	227	Low
29	Hepatocytes	Metabolism	152	Medium
30	Breast	Lactation	82	High
31	Spermatocytes	Spermatogenesis	213	High
32	Neurons	Synaptic function	237	High
33	Macrophages	Degranulation	283	High
34	Plasma cells	Humoral immune response	86	High
35	Bipolar cells	Visual perception	159	High
36	Spermatids	Spermatogenesis	419	High
37	Neurons	Neuronal signaling	496	High
38	Neurons	Neuronal signaling	626	High
39	Non-specific	Translation	186	Medium
40	Plasma cells	Humoral immune response	409	Medium
41	Alveolar cells	Lung function	118	Medium
42	Spermatocytes & Spermatids	Spermatogenesis	353	Medium
43	Non-specific	Cell proliferation	263	Medium
44	Photoreceptor cells	Visual perception	359	High
45	Plasma cells	Humoral immune response	78	High
46	Granulocytes	Mast cell degranulation	60	Medium
47	Spermatogonia	Spermatogenesis	119	Medium
48	Plasmacytoid dendritic cells	Unknown function	134	Low
49	Early spermatids	Spermatogenesis	272	High
50	Enterocytes	Absorption	308	Medium
51	Late spermatids	Spermatogenesis	389	High
52	Endometrial stromal cells	ECM organization	116	Medium
53	Connective tissue cells	ECM organization	187	Medium
54	Extravillous trophoblasts	Unknown function	188	Medium
55	Endocrine cells	Hormone signaling	81	High
56	Ciliated cells	Cilium assembly	425	High
57	Early spermatids	Flagellum & Golgi organization	325	Medium
58	Gastric mucus-secreting cells	Digestion	45	High
59	Proximal enterocytes	Transmembrane transport	209	High
60	Proximal tubular cells	Absorption	361	High
61	Non-specific	Transcription	366	Low
62	B-cells	B-cell activation	166	High
63	Astrocytes	Nervous system maintenance	208	High
64	Non-specific	Transcription	655	Medium
65	Fibroblasts	ECM organization	292	High
66	Endothelial cells	Angiogenesis	468	Medium
67	Syncytiotrophoblasts	Pregnancy	153	Medium
68	Muller glia cells	Visual perception	142	High
69	Macrophages	Innate immune response	217	High
70	Basal prostatic cells	Lipid metabolism	167	Medium
71	Erythroid cells	Oxygen transport	140	High
72	Smooth muscle cells	ECM organization	208	High
73	Prostatic glandular cells	Transcription	109	High
74	Pancreatic cells	Mixed function	331	Low
75	Myeloid cells	Innate immune response	390	Medium
76	Spermatocytes & Spermatogonia	Spermatogenesis	164	High
77	Cardiomyocytes	Muscle contraction	404	High

The interactive UMAP plot displays the 77 gene clusters resulting from Louvain clustering of gene expression across all single cell types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all single cell types for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.