Tissue expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in. Read more	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function. Read more	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Thyroid gland	Transcription	136	Low
2	Immune cells	Immune response	154	High
3	T-cells	Adaptive immune response	164	High
4	Stomach	Digestion	63	High
5	Breast	Unknown function	26	Medium
6	Brain	Smell perception	153	High
7	Kidney	Transmembrane transport	245	High
8	Non-specific	Mitochondria	389	Medium
9	Intestine	Unknown function	109	Medium
10	Brain	Neuronal signaling	359	High
11	Squamous epithelial cells	Epithelial cell function	186	Medium
12	Smooth muscle tissue	Mixed function	165	High
13	Striated muscle	Muscle contraction	318	High
14	B-cells	Humoral immune response	177	High
15	Liver	Metabolism	144	High
16	Immune cells	Immune response	321	High
17	Adrenal gland	Steroid metabolism	47	High
18	Non-specific	Mitochondria	290	High
19	Lung	Lung function	44	Medium
20	Retina & Lymphoid tissues	Unknown function	114	Low
21	Non-specific	Transcription	308	Low
22	Non-specific	Unknown function	169	Low
23	Testis	Cell cycle regulation	422	Medium
24	Salivary gland	Salivary secretion	125	Medium
25	Pancreas	Digestion	132	High
26	Pituitary gland	Hormone signaling	142	Medium
27	Brain & Skin	Unknown function	263	Very low
28	Placenta	Pregnancy	157	High
29	Non-specific	Vesicular transport	331	Medium
30	Epididymis	Antimicrobial activity	90	High
31	Skin	Epidermis development	222	High
32	Brain & Lymphoid tissue	Unknown function	329	Very low
33	Striated muscle	Muscle contraction	124	High
34	Non-specific	Transcription	557	Medium
35	Non-specific	Unknown function	358	Low
36	Testis	Spermatogenesis	95	High
37	Intestine	Unknown function	219	Low
38	Heart	Muscle contraction	78	Medium
39	Non-specific	Mitochondria	537	Medium
40	Neutrophils	Inflammatory response	209	Medium
41	Intestine & Liver	Lipid metabolism	148	Medium
42	Ciliated cells	Cilium & Cell projection	337	Medium
43	Testis	Unknown function	181	Low
44	Heart	Cardiac muscle contraction	131	Medium
45	Intestine	Brush border	134	Very low
46	Fibroblasts	ECM organization	177	High
47	Non-specific	Unknown function	63	Very low
48	Parathyroid gland	membrane proteins	245	Low
49	Ciliated cells	Cilium organization	148	High
50	Non-specific	Ribosome	210	Medium
51	Non-specific	Unknown function	73	Very low
52	Non-specific	Ribosome	127	Very low
53	Non-specific	Cell cycle regulation	216	Medium
54	Non-specific	Microtubule organization	78	Medium
55	Non-specific	Mitochondria & Proteasome	263	Medium
56	Intestine	Transmembrane transport	103	Medium
57	Non-specific	Angiogenesis	262	Low
58	Brain	Synaptic function	172	High
59	Non-specific	Translation	360	Medium
60	Liver	Hemostasis & Lipid metabolism	80	High
61	Skin	Cornification	199	High
62	Liver	Hemostasis	108	High
63	T-cells	Adaptive immune response	103	High
64	Macrophages	Immune response	264	High
65	Brain	Ion transport	264	High
66	Lymphoid tissue	Immune response regulation	96	Low
67	Neutrophils	Humoral immune response	162	Medium
68	Epididymis	Unknown function	336	Very low
69	Cerebellum	Gene expression regulation	205	Low
70	Brain	Nervous system development	344	High
71	Testis	DNA repair	276	Low
72	Non-specific	Transcription	302	Low
73	Brain	Neuropeptide signaling	272	High
74	Testis	Spermatogenesis	260	High
75	Bone marrow	mRNA splicing & Cell cycle	419	Low
76	Brain & Bone marrow	Chromatin organization	305	Medium
77	Retina	Visual perception	395	Medium
78	Testis	Spermatogenesis	411	High
79	Retina	Phototransduction	83	High
80	Striated muscle	Unknown function	379	Low
81	Kidney & Liver	Metabolism	78	Medium
82	Adipose tissue	ECM organization	265	Low
83	Testis	Spermatogenesis	241	High
84	Esophagus	Epithelial cell function	201	High
85	Liver	Metabolism	354	Medium
86	Liver & Placenta	Transport via ER	99	Low
87	Intestine & Kidney	Transmembrane transport	167	Medium
88	Choroid plexus	Transmembrane transport	121	High
89	Fibroblasts	ECM organization	335	Low

The interactive UMAP plot displays the 89 gene clusters resulting from Louvain clustering of gene expression across all tissue types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all tissue types for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.