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PAX6
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  • PAX6
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

PAX6
Synonyms AN, AN1, AN2, D11S812E, WAGR
Gene descriptioni

Full gene name according to HGNC.

Paired box 6
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
Transcription factors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 11
Cytoband p13
Chromosome location (bp) 31784779 - 31817961
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

56
Ensembl ENSG00000007372 (version 103.38)
Entrez gene 5080
HGNC HGNC:8620
UniProt P26367 (UniProt - Evidence at protein level)
neXtProt NX_P26367
Antibodypedia PAX6 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 31      # Population variants: 140

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
«
PAX6-201
PAX6-202
PAX6-203
PAX6-204
PAX6-205
PAX6-206
PAX6-207
PAX6-208
PAX6-209
PAX6-210
PAX6-211
PAX6-212
PAX6-217
PAX6-219
PAX6-220
PAX6-231
PAX6-232
PAX6-234
PAX6-235
PAX6-236
PAX6-237
PAX6-238
PAX6-239
PAX6-240
PAX6-241
PAX6-242
PAX6-244
PAX6-245
PAX6-246
PAX6-247
PAX6-248
PAX6-250
PAX6-251
PAX6-252
PAX6-254
PAX6-256
PAX6-257
PAX6-258
PAX6-259
PAX6-260
PAX6-261
PAX6-263
PAX6-265
PAX6-267
PAX6-268
PAX6-269
PAX6-270
PAX6-271
PAX6-272
PAX6-273
PAX6-275
PAX6-277
PAX6-279
PAX6-280
PAX6-281
PAX6-282
»


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
PAX6-201
ENSP00000241001
ENST00000241001
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
422 aa
46.7 kDa
No 0
PAX6-202
ENSP00000368401
ENST00000379107
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-203
ENSP00000368403
ENST00000379109
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
422 aa
46.7 kDa
No 0
PAX6-204
ENSP00000368406
ENST00000379111
A0A1W2PQA8 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
Show all
419 aa
46.3 kDa
No 0
PAX6-205
ENSP00000368410
ENST00000379115
A0A1X7SBT0 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
335 aa
37.2 kDa
No 0
PAX6-206
ENSP00000368418
ENST00000379123
A0A1W2PPJ2 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
282 aa
31.3 kDa
No 0
PAX6-207
ENSP00000368424
ENST00000379129
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-208
ENSP00000368427
ENST00000379132
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
422 aa
46.7 kDa
No 0
PAX6-209
ENSP00000404100
ENST00000419022
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-210
ENSP00000388132
ENST00000423822
B1B1I9 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
367 aa
40.5 kDa
No 0
PAX6-211
ENSP00000404356
ENST00000438681
B1B1I8 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
320 aa
35.5 kDa
No 0
PAX6-212
ENSP00000397384
ENST00000455099
B1B1J0 [Direct mapping]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
241 aa
26.5 kDa
No 0
PAX6-217
ENSP00000492205
ENST00000481563
A0A1W2PRA8 [Direct mapping]
Paired box gene 6 (Aniridia, keratitis), isoform CRA_b; Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
286 aa
31.8 kDa
No 0
PAX6-219
ENSP00000431585
ENST00000524853
E9PKM0 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
Show all
417 aa
46 kDa
No 0
PAX6-220
ENSP00000436365
ENST00000525535
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
3 aa
0.4 kDa
No 0
PAX6-231
ENSP00000480026
ENST00000606377
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-232
ENSP00000491365
ENST00000638250
A0A1W2PPJ2 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
282 aa
31.3 kDa
No 0
PAX6-234
ENSP00000491267
ENST00000638346
A0A1W2PP27 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
260 aa
28.9 kDa
No 0
PAX6-235
ENSP00000490971
ENST00000638629
A0A1W2PRA8 [Direct mapping]
Paired box gene 6 (Aniridia, keratitis), isoform CRA_b; Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
286 aa
31.8 kDa
No 0
PAX6-236
ENSP00000492316
ENST00000638685
A0A1W2PRH6 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
302 aa
34.6 kDa
No 1
PAX6-237
ENSP00000492756
ENST00000638696
A0A1W2PS91 [Direct mapping]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
400 aa
44.1 kDa
No 0
PAX6-238
ENSP00000492181
ENST00000638755
A0A1W2PQM7 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
Show all
386 aa
42.6 kDa
No 0
PAX6-239
ENSP00000491517
ENST00000638762
A0A1W2PPG3 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
238 aa
26.6 kDa
No 0
PAX6-240
ENSP00000492437
ENST00000638802
A0A1W2PRU4 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
263 aa
29.2 kDa
No 0
PAX6-241
ENSP00000491280
ENST00000638853
A0A1W2PQ31 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
277 aa
30.6 kDa
No 0
PAX6-242
ENSP00000492081
ENST00000638878
A0A1W2PQG3 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
231 aa
25.8 kDa
No 0
PAX6-244
ENSP00000492315
ENST00000638914
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-245
ENSP00000491948
ENST00000638963
A0A1W2PQG7 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001709 [cell fate determination]
GO:0001764 [neuron migration]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0002052 [positive regulation of neuroblast proliferation]
GO:0002088 [lens development in camera-type eye]
GO:0003002 [regionalization]
GO:0003309 [type B pancreatic cell differentiation]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0003723 [RNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007224 [smoothened signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007435 [salivary gland morphogenesis]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009786 [regulation of asymmetric cell division]
GO:0009950 [dorsal/ventral axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0021543 [pallium development]
GO:0021778 [oligodendrocyte cell fate specification]
GO:0021796 [cerebral cortex regionalization]
GO:0021798 [forebrain dorsal/ventral pattern formation]
GO:0021902 [commitment of neuronal cell to specific neuron type in forebrain]
GO:0021905 [forebrain-midbrain boundary formation]
GO:0021978 [telencephalon regionalization]
GO:0021983 [pituitary gland development]
GO:0021986 [habenula development]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030334 [regulation of cell migration]
GO:0030858 [positive regulation of epithelial cell differentiation]
GO:0030900 [forebrain development]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032808 [lacrimal gland development]
GO:0033365 [protein localization to organelle]
GO:0035035 [histone acetyltransferase binding]
GO:0042462 [eye photoreceptor cell development]
GO:0043010 [camera-type eye development]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048505 [regulation of timing of cell differentiation]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048708 [astrocyte differentiation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050767 [regulation of neurogenesis]
GO:0060041 [retina development in camera-type eye]
GO:0070410 [co-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0071837 [HMG box domain binding]
GO:1990830 [cellular response to leukemia inhibitory factor]
GO:2000178 [negative regulation of neural precursor cell proliferation]
Show all
473 aa
53.2 kDa
No 1
PAX6-246
ENSP00000492769
ENST00000638965
A0A1W2PSB5 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
221 aa
24.9 kDa
No 0
PAX6-247
ENSP00000491210
ENST00000639006
A0A1W2PP89 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
249 aa
27.9 kDa
No 0
PAX6-248
ENSP00000491679
ENST00000639034
D1KF47 [Direct mapping]
Paired box protein 6 isoform c; Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
Show all
401 aa
44.3 kDa
No 0
PAX6-250
ENSP00000491324
ENST00000639061
A0A1W2PPH0 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
283 aa
31.4 kDa
No 0
PAX6-251
ENSP00000492129
ENST00000639079
A0A1W2PQJ8 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
263 aa
29.2 kDa
No 0
PAX6-252
ENSP00000491904
ENST00000639109
A0A1W2PQ31 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
277 aa
30.6 kDa
No 0
PAX6-254
ENSP00000492658
ENST00000639386
A0A1W2PRA8 [Direct mapping]
Paired box gene 6 (Aniridia, keratitis), isoform CRA_b; Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
286 aa
31.8 kDa
No 0
PAX6-256
ENSP00000492476
ENST00000639409
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-257
ENSP00000491944
ENST00000639548
A0A1W2PRA8 [Direct mapping]
Paired box gene 6 (Aniridia, keratitis), isoform CRA_b; Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
286 aa
31.8 kDa
No 0
PAX6-258
ENSP00000490963
ENST00000639916
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
422 aa
46.7 kDa
No 0
PAX6-259
ENSP00000492111
ENST00000639920
A0A1W2PR58 [Direct mapping]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
72 aa
7.7 kDa
No 0
PAX6-260
ENSP00000491229
ENST00000639943
A0A1W2PPM5 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
314 aa
34.8 kDa
No 0
PAX6-261
ENSP00000491862
ENST00000639950
A0A1W2PQA8 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
Show all
419 aa
46.3 kDa
No 0
PAX6-263
ENSP00000492166
ENST00000640125
A0A1W2PRA8 [Direct mapping]
Paired box gene 6 (Aniridia, keratitis), isoform CRA_b; Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
286 aa
31.8 kDa
No 0
PAX6-265
ENSP00000492409
ENST00000640242
A0A1W2PRS6 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
Show all
341 aa
38 kDa
No 0
PAX6-267
ENSP00000492822
ENST00000640287
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
422 aa
46.7 kDa
No 0
PAX6-268
ENSP00000492808
ENST00000640335
A0A1W2PRW7 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
205 aa
23.2 kDa
No 0
PAX6-269
ENSP00000492024
ENST00000640368
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-270
ENSP00000491779
ENST00000640431
A0A1W2PQL7 [Direct mapping]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
370 aa
41.1 kDa
No 0
PAX6-271
ENSP00000492802
ENST00000640460
A0A1W2PSA8 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
Show all
413 aa
45.5 kDa
No 0
PAX6-272
ENSP00000491295
ENST00000640610
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
422 aa
46.7 kDa
No 0
PAX6-273
ENSP00000492587
ENST00000640613
A0A1W2PRG3 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
368 aa
40.6 kDa
No 0
PAX6-275
ENSP00000491492
ENST00000640684
A0A1W2PPN2 [Direct mapping]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
415 aa
45.8 kDa
No 0
PAX6-277
ENSP00000491214
ENST00000640766
A0A1W2PPH0 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
283 aa
31.4 kDa
No 0
PAX6-279
ENSP00000491065
ENST00000640872
A0A1W2PNS7 [Direct mapping]
Paired box protein Pax-6
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
281 aa
31.1 kDa
No 0
PAX6-280
ENSP00000492397
ENST00000640963
A0A1W2PRA4 [Direct mapping]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
382 aa
42.6 kDa
No 0
PAX6-281
ENSP00000491872
ENST00000640975
P26367 [Direct mapping]
Paired box protein Pax-6
F1T0F8 [Target identity:100%; Query identity:100%]
Paired box protein Pax-6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
436 aa
48.2 kDa
No 0
PAX6-282
ENSP00000495109
ENST00000643871
P26367 [Direct mapping]
Paired box protein Pax-6
Q66SS1 [Target identity:100%; Query identity:100%]
Paired box gene 6 isoform a; Paired box protein Pax-6 isoform a
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Nervous system diseases
   Eye disease
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001568 [blood vessel development]
GO:0001654 [eye development]
GO:0003322 [pancreatic A cell development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007275 [multicellular organism development]
GO:0007417 [central nervous system development]
GO:0007601 [visual perception]
GO:0008134 [transcription factor binding]
GO:0009611 [response to wounding]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0019901 [protein kinase binding]
GO:0021517 [ventral spinal cord development]
GO:0030154 [cell differentiation]
GO:0035035 [histone acetyltransferase binding]
GO:0042593 [glucose homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048663 [neuron fate commitment]
GO:0048856 [anatomical structure development]
GO:0050768 [negative regulation of neurogenesis]
GO:0061072 [iris morphogenesis]
GO:0061303 [cornea development in camera-type eye]
GO:0070412 [R-SMAD binding]
GO:1904798 [positive regulation of core promoter binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
Show all
422 aa
46.7 kDa
No 0

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