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CD4
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                                • CD4
                                BLOOD PROTEIN
                                Blood protein overview
                                GENERAL INFORMATIONi

                                General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

                                Gene namei

                                Official gene symbol, which is typically a short form of the gene name, according to HGNC.

                                CD4
                                Gene descriptioni

                                Full gene name according to HGNC.

                                CD4 molecule
                                Predicted locationi

                                All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

                                • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

                                • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

                                The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

                                Read more
                                Intracellular,Membrane
                                HUMAN PROTEIN ATLAS INFORMATION
                                Blood-based immunoassayi

                                The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.

                                Read more
                                Not analysed since only proteins predicted to be actively secreted to blood is analysed here
                                Mass spectrometryi

                                Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.

                                Not detected
                                Proximity extension assayi

                                Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years.

                                Read more
                                Detected
                                PROTEIN CONCENTRATION IN BLOOD - IMMUNOASSAYi

                                Plasma or serum concentrations of the genes annotated as actively secreted to blood. Up to three values for each gene were compiled from a literature search limited to studies where the protein concentration was determined using an antibody-based assay such as enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA) or immunoturbidimetry (IT).

                                Read more
                                Protein target not predicted to be actively secreted to blood and therefore not analyzed here
                                PROTEIN CONCENTRATION IN PLASMA - MASS SPECTROMETRYi

                                The protein concentration in blood is quantified by mass spectrometry-based plasma proteomics and estimated from spectral counts in a publicly available data set obtained from the PeptideAtlas.

                                Read more
                                Protein target not detected in plasma for reference set (Peptide atlas) by mass spectrometryi

                                Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years.

                                Read more
                                PROTEIN DETECTED IN PLASMA - PROXIMITY EXTENSION ASSAYi

                                The protein profiling results based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Protein expression levels are reported as Normalized Protein eXpression (NPX).

                                Read more
                                Detected in plasma by PEAi

                                The protein profiling results based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Protein expression levels are reported as Normalized Protein eXpression (NPX).

                                Read more
                                1230.00.20.40.60.81.01.21.41.61.82.02.22.42.62.8MaleScaled NPX
                                123Female
                                Visit


                                Detected in plasma by PEAi

                                The protein profiling results based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Protein expression levels are reported as Normalized Protein eXpression (NPX).

                                Read more
                                0.00.51.01.52.02.53.03.54.0123Scaled NPXVisitScaled NPXVisitMaleFemale

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                                The Project

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                                The Human Protein Atlas project is funded
                                by the Knut & Alice Wallenberg Foundation.