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FYN
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  • TISSUE

  • BRAIN

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  • PATHOLOGY

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  • FYN
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

FYN
Synonyms MGC45350, SLK, SYN
Gene descriptioni

Full gene name according to HGNC.

FYN proto-oncogene, Src family tyrosine kinase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Enzymes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 6
Cytoband q21
Chromosome location (bp) 111660332 - 111873452
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

19
Ensembl ENSG00000010810 (version 103.38)
Entrez gene 2534
HGNC HGNC:4037
UniProt P06241 (UniProt - Evidence at protein level)
neXtProt NX_P06241
Antibodypedia FYN antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
«
FYN-201
FYN-202
FYN-203
FYN-204
FYN-205
FYN-206
FYN-207
FYN-212
FYN-213
FYN-218
FYN-219
FYN-220
FYN-221
FYN-222
FYN-224
FYN-226
FYN-227
FYN-228
FYN-229
»


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
FYN-201
ENSP00000229471
ENST00000229471
P06241 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
482 aa
54.5 kDa
No 0
FYN-202
ENSP00000346671
ENST00000354650
P06241 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0001664 [G protein-coupled receptor binding]
GO:0001764 [neuron migration]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010629 [negative regulation of gene expression]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0010976 [positive regulation of neuron projection development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014069 [postsynaptic density]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030425 [dendrite]
GO:0030900 [forebrain development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042493 [response to drug]
GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein]
GO:0042542 [response to hydrogen peroxide]
GO:0042608 [T cell receptor binding]
GO:0042609 [CD4 receptor binding]
GO:0042610 [CD8 receptor binding]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0044297 [cell body]
GO:0044325 [ion channel binding]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048813 [dendrite morphogenesis]
GO:0050321 [tau-protein kinase activity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050798 [activated T cell proliferation]
GO:0050804 [modulation of chemical synaptic transmission]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051428 [peptide hormone receptor binding]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070851 [growth factor receptor binding]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071944 [cell periphery]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:0098685 [Schaffer collateral - CA1 synapse]
GO:0098978 [glutamatergic synapse]
GO:0099092 [postsynaptic density, intracellular component]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
537 aa
60.8 kDa
No 0
FYN-203
ENSP00000357656
ENST00000368667
P06241 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
537 aa
60.8 kDa
No 0
FYN-204
ENSP00000357667
ENST00000368678
P06241 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
534 aa
60.1 kDa
No 0
FYN-205
ENSP00000357671
ENST00000368682
P06241 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
534 aa
60.1 kDa
No 0
FYN-206
ENSP00000429590
ENST00000462598
E5RHX7 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
70 aa
7.5 kDa
No 0
FYN-207
ENSP00000427993
ENST00000462856
E5RFS5 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
Show all
232 aa
26 kDa
No 0
FYN-212
ENSP00000428983
ENST00000484067
E5RK23 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
106 aa
11.4 kDa
No 0
FYN-213
ENSP00000430455
ENST00000487824
E5RJX7 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
64 aa
7 kDa
No 0
FYN-218
ENSP00000429866
ENST00000517419
E5RH71 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
Show all
175 aa
19.3 kDa
No 0
FYN-219
ENSP00000428695
ENST00000518295
E5RGT0 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
153 aa
16.8 kDa
No 0
FYN-220
ENSP00000429813
ENST00000518630
E5RHF7 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
118 aa
12.8 kDa
No 0
FYN-221
ENSP00000429294
ENST00000520518
E5RIX5 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
Show all
186 aa
20.5 kDa
No 0
FYN-222
ENSP00000428042
ENST00000521062
E5RFM6 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
103 aa
11.1 kDa
No 0
FYN-224
ENSP00000430364
ENST00000523238
E5RFM0 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
152 aa
16.7 kDa
No 0
FYN-226
ENSP00000428045
ENST00000523570
E5RFM4 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
116 aa
12.6 kDa
No 0
FYN-227
ENSP00000429992
ENST00000523574
E5RGM6 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
139 aa
15.2 kDa
No 0
FYN-228
ENSP00000428493
ENST00000524310
E5RI25 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
145 aa
15.8 kDa
No 0
FYN-229
ENSP00000440646
ENST00000538466
P06241 [Direct mapping]
Tyrosine-protein kinase Fyn
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000304 [response to singlet oxygen]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0002376 [immune system process]
GO:0003015 [heart process]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0007612 [learning]
GO:0007631 [feeding behavior]
GO:0008360 [regulation of cell shape]
GO:0010730 [negative regulation of hydrogen peroxide biosynthetic process]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030425 [dendrite]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031802 [type 5 metabotropic glutamate receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell population proliferation]
GO:0042542 [response to hydrogen peroxide]
GO:0042802 [identical protein binding]
GO:0043014 [alpha-tubulin binding]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048156 [tau protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050321 [tau-protein kinase activity]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070851 [growth factor receptor binding]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097038 [perinuclear endoplasmic reticulum]
GO:0097062 [dendritic spine maintenance]
GO:0097386 [glial cell projection]
GO:0097718 [disordered domain specific binding]
GO:1900449 [regulation of glutamate receptor signaling pathway]
GO:1901216 [positive regulation of neuron death]
GO:1902951 [negative regulation of dendritic spine maintenance]
GO:1903202 [negative regulation of oxidative stress-induced cell death]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904645 [response to amyloid-beta]
GO:1904646 [cellular response to amyloid-beta]
GO:1905232 [cellular response to L-glutamate]
GO:1905430 [cellular response to glycine]
GO:1905477 [positive regulation of protein localization to membrane]
GO:1905664 [regulation of calcium ion import across plasma membrane]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
Show all
534 aa
60.1 kDa
No 0

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