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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Transcription factors Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q23.1
Chromosome location (bp)
100473708 - 100564414
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
NR1H4-201
NR1H4-203
NR1H4-204
NR1H4-206
NR1H4-207
NR1H4-208
NR1H4-209
NR1H4-210
NR1H4-211
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000791 [euchromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0008270 [zinc ion binding] GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [nuclear receptor binding] GO:0030154 [cell differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0032620 [interleukin-17 production] GO:0032689 [negative regulation of interferon-gamma production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0042025 [host cell nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050728 [negative regulation of inflammatory response] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1903413 [cellular response to bile acid] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Q96RI1 [Direct mapping] Bile acid receptor F1DAL1 [Target identity:100%; Query identity:100%] Farnesoid X nuclear receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_b
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000791 [euchromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0008270 [zinc ion binding] GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [nuclear receptor binding] GO:0030154 [cell differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0032620 [interleukin-17 production] GO:0032689 [negative regulation of interferon-gamma production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0042025 [host cell nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050728 [negative regulation of inflammatory response] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1903413 [cellular response to bile acid] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Digestive system diseases Liver diseases
Q96RI1 [Direct mapping] Bile acid receptor B6ZGS9 [Target identity:100%; Query identity:100%] Farnesoid X receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_a
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Nuclear receptors Transporters Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000791 [euchromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0008270 [zinc ion binding] GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [nuclear receptor binding] GO:0030154 [cell differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0032620 [interleukin-17 production] GO:0032689 [negative regulation of interferon-gamma production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0042025 [host cell nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050728 [negative regulation of inflammatory response] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1903413 [cellular response to bile acid] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000791 [euchromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0008270 [zinc ion binding] GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [nuclear receptor binding] GO:0030154 [cell differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0032620 [interleukin-17 production] GO:0032689 [negative regulation of interferon-gamma production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050728 [negative regulation of inflammatory response] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1903413 [cellular response to bile acid] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Digestive system diseases Liver diseases
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000791 [euchromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001678 [cellular glucose homeostasis] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007043 [cell-cell junction assembly] GO:0007219 [Notch signaling pathway] GO:0008206 [bile acid metabolic process] GO:0008270 [zinc ion binding] GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [nuclear receptor binding] GO:0030154 [cell differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032620 [interleukin-17 production] GO:0032689 [negative regulation of interferon-gamma production] GO:0032692 [negative regulation of interleukin-1 production] GO:0032703 [negative regulation of interleukin-2 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0042025 [host cell nucleus] GO:0042593 [glucose homeostasis] GO:0042632 [cholesterol homeostasis] GO:0042742 [defense response to bacterium] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046628 [positive regulation of insulin receptor signaling pathway] GO:0046872 [metal ion binding] GO:0046965 [retinoid X receptor binding] GO:0050728 [negative regulation of inflammatory response] GO:0055089 [fatty acid homeostasis] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070328 [triglyceride homeostasis] GO:0070857 [regulation of bile acid biosynthetic process] GO:0071222 [cellular response to lipopolysaccharide] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0071638 [negative regulation of monocyte chemotactic protein-1 production] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1903413 [cellular response to bile acid] GO:1904179 [positive regulation of adipose tissue development] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process] GO:2001250 [positive regulation of ammonia assimilation cycle]
Q96RI1 [Direct mapping] Bile acid receptor F1DAL1 [Target identity:100%; Query identity:100%] Farnesoid X nuclear receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_b
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Digestive system diseases Liver diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000791 [euchromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002376 [immune system process] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0008270 [zinc ion binding] GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling] GO:0010988 [regulation of low-density lipoprotein particle clearance] GO:0015721 [bile acid and bile salt transport] GO:0016922 [nuclear receptor binding] GO:0030154 [cell differentiation] GO:0030522 [intracellular receptor signaling pathway] GO:0032052 [bile acid binding] GO:0032620 [interleukin-17 production] GO:0032689 [negative regulation of interferon-gamma production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034255 [regulation of urea metabolic process] GO:0034971 [histone H3-R17 methylation] GO:0035356 [cellular triglyceride homeostasis] GO:0038181 [bile acid receptor activity] GO:0038183 [bile acid signaling pathway] GO:0038185 [intracellular bile acid receptor signaling pathway] GO:0042025 [host cell nucleus] GO:0043066 [negative regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043235 [receptor complex] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050728 [negative regulation of inflammatory response] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070857 [regulation of bile acid biosynthetic process] GO:0071398 [cellular response to fatty acid] GO:0071417 [cellular response to organonitrogen compound] GO:0090181 [regulation of cholesterol metabolic process] GO:1902122 [chenodeoxycholic acid binding] GO:1903413 [cellular response to bile acid] GO:1905695 [positive regulation of phosphatidic acid biosynthetic process] GO:2000213 [positive regulation of glutamate metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Digestive system diseases Liver diseases
The Human Protein Atlas project is funded
