GENERAL INFORMATIONi
Gene namei DDX11
Synonyms CHL1, CHLR1, KRG2, WABS
Gene descriptioni DEAD/H-box helicase 11
Protein classi Disease related genes
Enzymes
Human disease related genes
Potential drug targets
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 12
Cytoband p11.21
Chromosome location (bp) 31073860 - 31104799
Number of transcriptsi 9
Ensembl ENSG00000013573 (version 103.38)
Entrez gene 1663
HGNC HGNC:2736
UniProt Q96FC9 (UniProt - Evidence at protein level)
neXtProt NX_Q96FC9
Antibodypedia DDX11 antibodies


PROTEIN STRUCTUREi

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 5      # Population variants: 715

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On


PROTEIN BROWSERi
DDX11-201
DDX11-202
DDX11-203
DDX11-205
DDX11-207
DDX11-216
DDX11-223
DDX11-227
DDX11-229


PROTEIN INFORMATIONi
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
DDX11-201
ENSP00000228264
ENST00000228264
Q96FC9 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000785 [chromatin]
GO:0000922 [spindle pole]
GO:0001650 [fibrillar center]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007062 [sister chromatid cohesion]
GO:0007275 [multicellular organism development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008186 [RNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0031297 [replication fork processing]
GO:0031390 [Ctf18 RFC-like complex]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032508 [DNA duplex unwinding]
GO:0034085 [establishment of sister chromatid cohesion]
GO:0035563 [positive regulation of chromatin binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044806 [G-quadruplex DNA unwinding]
GO:0045142 [triplex DNA binding]
GO:0045876 [positive regulation of sister chromatid cohesion]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0072711 [cellular response to hydroxyurea]
GO:0072719 [cellular response to cisplatin]
GO:1901838 [positive regulation of transcription of nucleolar large rRNA by RNA polymerase I]
GO:1904976 [cellular response to bleomycin]
GO:1990700 [nucleolar chromatin organization]
GO:2000781 [positive regulation of double-strand break repair]
Show all
 880 aa
98.7 kDa 		No 0
DDX11-202
ENSP00000309965
ENST00000350437
Q96FC9 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000785 [chromatin]
GO:0000922 [spindle pole]
GO:0001650 [fibrillar center]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007062 [sister chromatid cohesion]
GO:0007275 [multicellular organism development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008186 [RNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0031297 [replication fork processing]
GO:0031390 [Ctf18 RFC-like complex]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032508 [DNA duplex unwinding]
GO:0034085 [establishment of sister chromatid cohesion]
GO:0035563 [positive regulation of chromatin binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044806 [G-quadruplex DNA unwinding]
GO:0045142 [triplex DNA binding]
GO:0045876 [positive regulation of sister chromatid cohesion]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0072711 [cellular response to hydroxyurea]
GO:0072719 [cellular response to cisplatin]
GO:1901838 [positive regulation of transcription of nucleolar large rRNA by RNA polymerase I]
GO:1904976 [cellular response to bleomycin]
GO:1990700 [nucleolar chromatin organization]
GO:2000781 [positive regulation of double-strand break repair]
Show all
 856 aa
96.1 kDa 		No 0
DDX11-203
ENSP00000406457
ENST00000415475
F5GXJ8 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001650 [fibrillar center]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
Show all
 224 aa
25.9 kDa 		No 0
DDX11-205
ENSP00000407646
ENST00000438391
C9K0E8 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001650 [fibrillar center]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
Show all
 302 aa
34.6 kDa 		No 0
DDX11-207
ENSP00000440171
ENST00000535317
F5GXL6 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001650 [fibrillar center]
GO:0003678 [DNA helicase activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0032508 [DNA duplex unwinding]
Show all
 191 aa
21.4 kDa 		No 0
DDX11-216
ENSP00000441015
ENST00000539702
H0YFY8 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
Show all
 172 aa
18.7 kDa 		No 0
DDX11-223
ENSP00000443426
ENST00000542838
Q96FC9 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000785 [chromatin]
GO:0000922 [spindle pole]
GO:0001650 [fibrillar center]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007062 [sister chromatid cohesion]
GO:0007275 [multicellular organism development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008186 [RNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0031297 [replication fork processing]
GO:0031390 [Ctf18 RFC-like complex]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032508 [DNA duplex unwinding]
GO:0034085 [establishment of sister chromatid cohesion]
GO:0035563 [positive regulation of chromatin binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044806 [G-quadruplex DNA unwinding]
GO:0045142 [triplex DNA binding]
GO:0045876 [positive regulation of sister chromatid cohesion]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0072711 [cellular response to hydroxyurea]
GO:0072719 [cellular response to cisplatin]
GO:1901838 [positive regulation of transcription of nucleolar large rRNA by RNA polymerase I]
GO:1904976 [cellular response to bleomycin]
GO:1990700 [nucleolar chromatin organization]
GO:2000781 [positive regulation of double-strand break repair]
Show all
 906 aa
101.7 kDa 		No 0
DDX11-227
ENSP00000473610
ENST00000544652
R4GNE1 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001650 [fibrillar center]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005813 [centrosome]
Show all
 91 aa
9.9 kDa 		No 0
DDX11-229
ENSP00000440402
ENST00000545668
Q96FC9 [Direct mapping]
ATP-dependent DNA helicase DDX11
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Disease related genes
Potential drug targets
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000785 [chromatin]
GO:0000922 [spindle pole]
GO:0001650 [fibrillar center]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003678 [DNA helicase activity]
GO:0003682 [chromatin binding]
GO:0003688 [DNA replication origin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005856 [cytoskeleton]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007062 [sister chromatid cohesion]
GO:0007275 [multicellular organism development]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008186 [RNA-dependent ATPase activity]
GO:0016032 [viral process]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030496 [midbody]
GO:0031297 [replication fork processing]
GO:0031390 [Ctf18 RFC-like complex]
GO:0032079 [positive regulation of endodeoxyribonuclease activity]
GO:0032091 [negative regulation of protein binding]
GO:0032508 [DNA duplex unwinding]
GO:0034085 [establishment of sister chromatid cohesion]
GO:0035563 [positive regulation of chromatin binding]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044806 [G-quadruplex DNA unwinding]
GO:0045142 [triplex DNA binding]
GO:0045876 [positive regulation of sister chromatid cohesion]
GO:0046872 [metal ion binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0051880 [G-quadruplex DNA binding]
GO:0070062 [extracellular exosome]
GO:0072711 [cellular response to hydroxyurea]
GO:0072719 [cellular response to cisplatin]
GO:1901838 [positive regulation of transcription of nucleolar large rRNA by RNA polymerase I]
GO:1904976 [cellular response to bleomycin]
GO:1990700 [nucleolar chromatin organization]
GO:2000781 [positive regulation of double-strand break repair]
Show all
 970 aa
108.3 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.