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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Disease related genes Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q23.2
Chromosome location (bp)
102395874 - 102481744
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
IGF1-201
IGF1-202
IGF1-203
IGF1-204
IGF1-205
IGF1-207
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P05019 [Direct mapping] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000187 [activation of MAPK activity] GO:0001501 [skeletal system development] GO:0001775 [cell activation] GO:0002576 [platelet degranulation] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005178 [integrin binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007517 [muscle organ development] GO:0008083 [growth factor activity] GO:0008283 [cell population proliferation] GO:0008284 [positive regulation of cell population proliferation] GO:0009408 [response to heat] GO:0009441 [glycolate metabolic process] GO:0010468 [regulation of gene expression] GO:0010560 [positive regulation of glycoprotein biosynthetic process] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896 [muscle hypertrophy] GO:0014904 [myotube cell development] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0030166 [proteoglycan biosynthetic process] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0032148 [activation of protein kinase B activity] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034392 [negative regulation of smooth muscle cell apoptotic process] GO:0035630 [bone mineralization involved in bone maturation] GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0040014 [regulation of multicellular organism growth] GO:0042060 [wound healing] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567 [insulin-like growth factor ternary complex] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043410 [positive regulation of MAPK cascade] GO:0043491 [protein kinase B signaling] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045445 [myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046326 [positive regulation of glucose import] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050714 [positive regulation of protein secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051450 [myoblast proliferation] GO:0060283 [negative regulation of oocyte development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371 [ERK1 and ERK2 cascade] GO:0070382 [exocytic vesicle] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0150079 [negative regulation of neuroinflammatory response] GO:1902430 [negative regulation of amyloid-beta formation] GO:1904075 [positive regulation of trophectodermal cell proliferation] GO:1904646 [cellular response to amyloid-beta] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460 [negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I Q5U743 [Target identity:100%; Query identity:100%] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001501 [skeletal system development] GO:0001775 [cell activation] GO:0002576 [platelet degranulation] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005178 [integrin binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007517 [muscle organ development] GO:0008083 [growth factor activity] GO:0008283 [cell population proliferation] GO:0008284 [positive regulation of cell population proliferation] GO:0009408 [response to heat] GO:0009441 [glycolate metabolic process] GO:0010468 [regulation of gene expression] GO:0010560 [positive regulation of glycoprotein biosynthetic process] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896 [muscle hypertrophy] GO:0014904 [myotube cell development] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0030166 [proteoglycan biosynthetic process] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0032148 [activation of protein kinase B activity] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034392 [negative regulation of smooth muscle cell apoptotic process] GO:0035630 [bone mineralization involved in bone maturation] GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0040014 [regulation of multicellular organism growth] GO:0042060 [wound healing] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567 [insulin-like growth factor ternary complex] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043410 [positive regulation of MAPK cascade] GO:0043491 [protein kinase B signaling] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045445 [myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046326 [positive regulation of glucose import] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050714 [positive regulation of protein secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051450 [myoblast proliferation] GO:0060283 [negative regulation of oocyte development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371 [ERK1 and ERK2 cascade] GO:0070382 [exocytic vesicle] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0150079 [negative regulation of neuroinflammatory response] GO:1902430 [negative regulation of amyloid-beta formation] GO:1904075 [positive regulation of trophectodermal cell proliferation] GO:1904646 [cellular response to amyloid-beta] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460 [negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001501 [skeletal system development] GO:0001775 [cell activation] GO:0002576 [platelet degranulation] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005178 [integrin binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007517 [muscle organ development] GO:0008083 [growth factor activity] GO:0008283 [cell population proliferation] GO:0008284 [positive regulation of cell population proliferation] GO:0009408 [response to heat] GO:0009441 [glycolate metabolic process] GO:0010468 [regulation of gene expression] GO:0010560 [positive regulation of glycoprotein biosynthetic process] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896 [muscle hypertrophy] GO:0014904 [myotube cell development] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0030166 [proteoglycan biosynthetic process] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0032148 [activation of protein kinase B activity] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034392 [negative regulation of smooth muscle cell apoptotic process] GO:0035630 [bone mineralization involved in bone maturation] GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0040014 [regulation of multicellular organism growth] GO:0042060 [wound healing] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567 [insulin-like growth factor ternary complex] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043410 [positive regulation of MAPK cascade] GO:0043491 [protein kinase B signaling] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045445 [myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046326 [positive regulation of glucose import] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050714 [positive regulation of protein secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051450 [myoblast proliferation] GO:0060283 [negative regulation of oocyte development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371 [ERK1 and ERK2 cascade] GO:0070382 [exocytic vesicle] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0150079 [negative regulation of neuroinflammatory response] GO:1902430 [negative regulation of amyloid-beta formation] GO:1904075 [positive regulation of trophectodermal cell proliferation] GO:1904646 [cellular response to amyloid-beta] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460 [negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001501 [skeletal system development] GO:0001775 [cell activation] GO:0002576 [platelet degranulation] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005178 [integrin binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007517 [muscle organ development] GO:0008083 [growth factor activity] GO:0008283 [cell population proliferation] GO:0008284 [positive regulation of cell population proliferation] GO:0009408 [response to heat] GO:0009441 [glycolate metabolic process] GO:0010468 [regulation of gene expression] GO:0010560 [positive regulation of glycoprotein biosynthetic process] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896 [muscle hypertrophy] GO:0014904 [myotube cell development] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0030166 [proteoglycan biosynthetic process] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0032148 [activation of protein kinase B activity] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034392 [negative regulation of smooth muscle cell apoptotic process] GO:0035630 [bone mineralization involved in bone maturation] GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0040014 [regulation of multicellular organism growth] GO:0042060 [wound healing] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567 [insulin-like growth factor ternary complex] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043410 [positive regulation of MAPK cascade] GO:0043491 [protein kinase B signaling] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045445 [myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046326 [positive regulation of glucose import] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050714 [positive regulation of protein secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051450 [myoblast proliferation] GO:0060283 [negative regulation of oocyte development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371 [ERK1 and ERK2 cascade] GO:0070382 [exocytic vesicle] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0150079 [negative regulation of neuroinflammatory response] GO:1902430 [negative regulation of amyloid-beta formation] GO:1904075 [positive regulation of trophectodermal cell proliferation] GO:1904646 [cellular response to amyloid-beta] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460 [negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity] GO:0001501 [skeletal system development] GO:0001775 [cell activation] GO:0002576 [platelet degranulation] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005178 [integrin binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007517 [muscle organ development] GO:0008083 [growth factor activity] GO:0008283 [cell population proliferation] GO:0008284 [positive regulation of cell population proliferation] GO:0009408 [response to heat] GO:0009441 [glycolate metabolic process] GO:0010468 [regulation of gene expression] GO:0010560 [positive regulation of glycoprotein biosynthetic process] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896 [muscle hypertrophy] GO:0014904 [myotube cell development] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0030166 [proteoglycan biosynthetic process] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0032148 [activation of protein kinase B activity] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034392 [negative regulation of smooth muscle cell apoptotic process] GO:0035630 [bone mineralization involved in bone maturation] GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0040014 [regulation of multicellular organism growth] GO:0042060 [wound healing] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567 [insulin-like growth factor ternary complex] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043410 [positive regulation of MAPK cascade] GO:0043491 [protein kinase B signaling] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045445 [myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046326 [positive regulation of glucose import] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050714 [positive regulation of protein secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051450 [myoblast proliferation] GO:0060283 [negative regulation of oocyte development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371 [ERK1 and ERK2 cascade] GO:0070382 [exocytic vesicle] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0150079 [negative regulation of neuroinflammatory response] GO:1902430 [negative regulation of amyloid-beta formation] GO:1904075 [positive regulation of trophectodermal cell proliferation] GO:1904646 [cellular response to amyloid-beta] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460 [negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
P05019 [Direct mapping] Insulin-like growth factor I Q5U743 [Target identity:100%; Query identity:100%] Insulin-like growth factor I
Show all
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Disease related genes Human disease related genes Cancers Cancers of the lung and pleura Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000187 [activation of MAPK activity] GO:0001501 [skeletal system development] GO:0001775 [cell activation] GO:0002576 [platelet degranulation] GO:0005158 [insulin receptor binding] GO:0005159 [insulin-like growth factor receptor binding] GO:0005178 [integrin binding] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007517 [muscle organ development] GO:0008083 [growth factor activity] GO:0008283 [cell population proliferation] GO:0008284 [positive regulation of cell population proliferation] GO:0009408 [response to heat] GO:0009441 [glycolate metabolic process] GO:0010468 [regulation of gene expression] GO:0010560 [positive regulation of glycoprotein biosynthetic process] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0014834 [skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration] GO:0014896 [muscle hypertrophy] GO:0014904 [myotube cell development] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0030166 [proteoglycan biosynthetic process] GO:0030335 [positive regulation of cell migration] GO:0031093 [platelet alpha granule lumen] GO:0032148 [activation of protein kinase B activity] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034392 [negative regulation of smooth muscle cell apoptotic process] GO:0035630 [bone mineralization involved in bone maturation] GO:0035867 [alphav-beta3 integrin-IGF-1-IGF1R complex] GO:0040014 [regulation of multicellular organism growth] GO:0042060 [wound healing] GO:0042104 [positive regulation of activated T cell proliferation] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042567 [insulin-like growth factor ternary complex] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043410 [positive regulation of MAPK cascade] GO:0043491 [protein kinase B signaling] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045445 [myoblast differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045821 [positive regulation of glycolytic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046326 [positive regulation of glucose import] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0048009 [insulin-like growth factor receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050714 [positive regulation of protein secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050821 [protein stabilization] GO:0051450 [myoblast proliferation] GO:0060283 [negative regulation of oocyte development] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070371 [ERK1 and ERK2 cascade] GO:0070382 [exocytic vesicle] GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade] GO:0090201 [negative regulation of release of cytochrome c from mitochondria] GO:0150079 [negative regulation of neuroinflammatory response] GO:1902430 [negative regulation of amyloid-beta formation] GO:1904075 [positive regulation of trophectodermal cell proliferation] GO:1904646 [cellular response to amyloid-beta] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1905460 [negative regulation of vascular associated smooth muscle cell apoptotic process] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
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