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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:125.4 nTPM
HPA:125.4 nTPM
GTEx:110.3 nTPM
FANTOM5:31.3 Scaled Tags Per Million
Pig:90.0 nTPM
Mouse:99.8 nTPM
Allen mouse:4.5 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 125.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 99.5
2586 Male, age 75, left hemisphere 109.4
1827 Male, age 72, unknown 107.1
2828 Female, age 72, unknown 105.5
2019 Male, age 18, unknown 100.5
2666 Male, age 74, left hemisphere 99.6
2219 Male, age 76, both hemispheres 98.9
1870 Female, age 42, unknown 95.1
2411 Female, age 72, unknown 95.0
1833 Male, age 53, unknown 92.9
1830 Male, age 51, unknown 90.8
Dorsal raphe nucleus
nTPM: 117.2
2298 Female, age 72, unknown 144.0
2047 Male, age 72, unknown 119.3
2016 Female, age 72, unknown 118.8
1828 Male, age 53, unknown 104.3
2750 Male, age 76, both hemispheres 99.6
Inferior colliculus
nTPM: 104.9
2097 Female, age 72, unknown 110.3
1848 Female, age 42, unknown 104.1
1890 Male, age 53, unknown 103.5
2849 Male, age 72, unknown 101.7
Median raphe nucleus
nTPM: 108.4
2220 Male, age 76, midline 108.4
Pedunculopontine tegmental nucleus
nTPM: 96.9
1921 Female, age 85, both hemispheres 100.8
2334 Male, age 80, both hemispheres 99.2
2338 Male, age 61, both hemispheres 90.8
Periaquaductal grey, anterior
nTPM: 117.6
1795 Male, age 51, unknown 125.1
2502 Female, age 75, unknown 122.0
1947 Male, age 18, unknown 105.7
Periaquaductal grey, dorsal
nTPM: 120.9
1840 Male, age 53, unknown 138.4
2850 Male, age 76, both hemispheres 126.0
2464 Female, age 72, unknown 111.8
1831 Male, age 72, unknown 107.4
Periaquaductal grey, lateral
nTPM: 125.4
2272 Male, age 74, both hemispheres 132.4
2140 Male, age 76, both hemispheres 125.8
2053 Male, age 18, unknown 118.1
Pretectal area
nTPM: 118.0
2273 Male, age 74, both hemispheres 147.6
2224 Female, age 72, unknown 127.1
1816 Male, age 51, unknown 124.1
1944 Female, age 72, unknown 118.8
1815 Male, age 53, unknown 117.5
1817 Female, age 42, unknown 117.4
2007 Male, age 72, unknown 114.5
2407 Male, age 75, both hemispheres 112.6
2667 Female, age 75, unknown 110.8
2825 Male, age 18, unknown 105.8
2316 Male, age 76, right hemisphere 101.6
Red nucleus
nTPM: 91.8
2785 Male, age 18, unknown 105.2
2725 Female, age 75, unknown 96.2
1821 Female, age 72, unknown 93.0
1904 Male, age 53, unknown 92.6
2769 Male, age 72, unknown 92.5
2227 Male, age 72, unknown 92.3
2503 Female, age 72, unknown 92.1
2584 Male, age 75, left hemisphere 91.7
1954 Female, age 42, unknown 90.8
1865 Male, age 51, unknown 87.7
2823 Male, age 76, right hemisphere 84.5
2588 Male, age 74, left hemisphere 83.4
Substantia nigra
nTPM: 110.9
1916 Female, age 42, unknown 123.2
1851 Male, age 51, unknown 118.7
2241 Male, age 72, unknown 114.8
2699 Male, age 18, unknown 114.7
2590 Female, age 75, unknown 112.4
1889 Female, age 72, unknown 107.8
2583 Male, age 75, right hemisphere 106.2
1941 Male, age 53, unknown 104.9
2665 Male, age 74, both hemispheres 104.9
2409 Female, age 72, unknown 101.7
Superior colliculus
nTPM: 109.3
2664 Male, age 75, both hemispheres 130.6
1796 Male, age 53, unknown 116.4
2087 Female, age 72, unknown 116.0
2261 Male, age 18, unknown 113.3
2587 Male, age 74, left hemisphere 110.8
1995 Male, age 72, unknown 106.7
1839 Male, age 51, unknown 105.1
2668 Female, age 75, unknown 102.1
1913 Female, age 42, unknown 97.6
1895 Male, age 76, right hemisphere 94.8
Ventral tegmental area
nTPM: 109.1
2410 Female, age 72, unknown 115.1
1915 Female, age 42, unknown 114.0
2021 Male, age 53, unknown 112.0
1942 Male, age 51, unknown 109.2
2218 Male, age 76, both hemispheres 105.8
2223 Female, age 72, unknown 98.4

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 110.3
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 110.3
Samples: 139

Max nTPM: 249.9
Min nTPM: 22.4
Std nTPM: 35.4
Median nTPM: 106.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 249.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 219.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 217.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 195.8
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 195.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 170.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 170.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 166.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 165.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 164.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 161.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 160.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 157.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 154.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 154.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 154.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 152.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 152.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 152.1
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 150.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 150.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 145.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 143.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 140.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 138.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 135.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 133.6
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 132.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 129.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 129.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 128.3
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 127.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 126.2
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 123.9
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 123.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 122.7
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 122.1
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 121.3
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 121.0
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 120.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 119.7
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 119.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 118.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 117.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 116.8
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 116.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 116.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 116.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 116.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 115.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 115.3
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 115.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 114.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 114.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 114.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 114.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 114.4
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 112.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 111.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 111.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 110.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 109.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 109.3
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 109.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 108.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 108.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 107.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 107.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 107.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 106.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 106.0
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 105.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 105.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 104.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 104.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 104.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 104.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 103.6
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 103.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 103.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 103.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 102.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 102.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 102.5
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 102.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 101.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 100.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 99.8
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 99.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 99.7
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 99.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 99.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 98.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 96.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 95.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 95.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 94.9
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 94.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 94.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 93.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 93.2
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 92.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 92.6
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 92.5
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 92.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 88.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 86.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 86.3
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 85.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 85.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 85.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 85.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 84.5
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 84.4
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 83.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 83.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 81.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 81.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 81.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 77.8
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 76.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 76.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 76.1
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 74.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 74.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 72.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 69.8
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 65.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 59.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 59.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 56.8
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 51.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 51.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 49.6
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 48.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 46.1
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 43.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 38.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 22.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 31.3
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 31.3
FF:10158-103A5 76 years, female 31.3

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 90.0
Pig sample Sample description nTPM
Midbrain
nTPM: 48.7
Samples: 4

Max nTPM: 51.4
Min nTPM: 45.6
Sample A Female 50.1
Sample B Female 51.4
Sample C Male 47.8
Sample D Male 45.6
Periaqueductal gray
nTPM: 90.0
Samples: 3

Max nTPM: 115.6
Min nTPM: 70.0
Sample B Female 70.0
Sample C Male 115.6
Sample D Male 84.3
Substantia nigra
nTPM: 52.3
Samples: 4

Max nTPM: 63.5
Min nTPM: 29.4
Sample A Female 61.0
Sample B Female 63.5
Sample C Male 55.1
Sample D Male 29.4
Superior colliculi
nTPM: 39.6
Samples: 4

Max nTPM: 48.5
Min nTPM: 29.9
Sample A Female 48.5
Sample B Female 34.7
Sample C Male 29.9
Sample D Male 45.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 99.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 99.8
Samples: 4

Max nTPM: 101.6
Min nTPM: 98.2
Sample A Male 100.4
Sample B Male 101.6
Sample C Female 98.2
Sample D Female 99.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 4.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 4.5
2219 Antisense, RP_040604_01_A03, Mouse strain C57BL/6J (56 days, male) 4.5
2218 Antisense, RP_040604_01_A03, Mouse strain C57BL/6J (56 days, male) 1.4

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