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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:61.9 nTPM
HPA:61.9 nTPM
GTEx:42.5 nTPM
FANTOM5:20.8 Scaled Tags Per Million
Pig:33.2 nTPM
Mouse:45.3 nTPM
Allen mouse:1.5 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 61.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 38.9
2219 Male, age 76, both hemispheres 52.0
2586 Male, age 75, left hemisphere 47.9
2828 Female, age 72, unknown 40.1
1833 Male, age 53, unknown 40.0
1827 Male, age 72, unknown 39.7
1830 Male, age 51, unknown 37.1
2411 Female, age 72, unknown 35.0
1870 Female, age 42, unknown 34.7
2666 Male, age 74, left hemisphere 33.4
2019 Male, age 18, unknown 29.4
Dorsal raphe nucleus
nTPM: 36.6
2016 Female, age 72, unknown 42.4
2047 Male, age 72, unknown 37.8
2298 Female, age 72, unknown 37.6
1828 Male, age 53, unknown 35.8
2750 Male, age 76, both hemispheres 29.4
Inferior colliculus
nTPM: 44.1
1848 Female, age 42, unknown 55.9
2849 Male, age 72, unknown 50.3
1890 Male, age 53, unknown 35.6
2097 Female, age 72, unknown 34.7
Median raphe nucleus
nTPM: 32.9
2220 Male, age 76, midline 32.9
Pedunculopontine tegmental nucleus
nTPM: 33.6
1921 Female, age 85, both hemispheres 36.0
2334 Male, age 80, both hemispheres 32.7
2338 Male, age 61, both hemispheres 32.1
Periaquaductal grey, anterior
nTPM: 34.3
2502 Female, age 75, unknown 38.5
1795 Male, age 51, unknown 32.8
1947 Male, age 18, unknown 31.6
Periaquaductal grey, dorsal
nTPM: 44.0
1840 Male, age 53, unknown 59.5
1831 Male, age 72, unknown 41.3
2464 Female, age 72, unknown 39.8
2850 Male, age 76, both hemispheres 35.3
Periaquaductal grey, lateral
nTPM: 40.0
2053 Male, age 18, unknown 45.2
2140 Male, age 76, both hemispheres 39.5
2272 Male, age 74, both hemispheres 35.2
Pretectal area
nTPM: 35.6
2825 Male, age 18, unknown 42.0
2667 Female, age 75, unknown 40.3
2224 Female, age 72, unknown 39.7
2407 Male, age 75, both hemispheres 39.2
2273 Male, age 74, both hemispheres 37.8
1944 Female, age 72, unknown 33.8
2316 Male, age 76, right hemisphere 33.8
1817 Female, age 42, unknown 33.1
1815 Male, age 53, unknown 31.9
1816 Male, age 51, unknown 31.3
2007 Male, age 72, unknown 28.5
Red nucleus
nTPM: 33.8
2227 Male, age 72, unknown 37.0
1821 Female, age 72, unknown 36.8
2503 Female, age 72, unknown 36.3
2588 Male, age 74, left hemisphere 36.1
1954 Female, age 42, unknown 34.7
2725 Female, age 75, unknown 34.4
2584 Male, age 75, left hemisphere 33.8
2769 Male, age 72, unknown 33.3
1865 Male, age 51, unknown 32.5
1904 Male, age 53, unknown 31.0
2823 Male, age 76, right hemisphere 30.5
2785 Male, age 18, unknown 29.1
Substantia nigra
nTPM: 61.9
2699 Male, age 18, unknown 118.5
1916 Female, age 42, unknown 84.7
1941 Male, age 53, unknown 75.3
2241 Male, age 72, unknown 67.3
1851 Male, age 51, unknown 61.0
2409 Female, age 72, unknown 49.7
2665 Male, age 74, both hemispheres 45.8
2583 Male, age 75, right hemisphere 41.7
1889 Female, age 72, unknown 38.1
2590 Female, age 75, unknown 37.1
Superior colliculus
nTPM: 38.5
1796 Male, age 53, unknown 47.1
1895 Male, age 76, right hemisphere 46.0
1839 Male, age 51, unknown 44.3
2664 Male, age 75, both hemispheres 39.9
2668 Female, age 75, unknown 39.3
2587 Male, age 74, left hemisphere 36.3
2087 Female, age 72, unknown 35.4
1913 Female, age 42, unknown 32.3
1995 Male, age 72, unknown 32.2
2261 Male, age 18, unknown 31.9
Ventral tegmental area
nTPM: 54.4
1915 Female, age 42, unknown 72.0
2218 Male, age 76, both hemispheres 65.4
1942 Male, age 51, unknown 53.8
2410 Female, age 72, unknown 52.6
2223 Female, age 72, unknown 47.0
2021 Male, age 53, unknown 35.6

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 42.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 42.5
Samples: 139

Max nTPM: 130.3
Min nTPM: 5.6
Std nTPM: 20.1
Median nTPM: 37.6
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 130.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 95.0
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 92.7
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 86.0
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 85.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 85.0
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 82.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 81.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 81.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 77.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 75.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 74.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 73.8
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 71.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 69.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 69.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 67.6
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 66.7
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 65.4
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 64.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 64.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 62.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 61.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 59.1
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 59.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 58.6
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 58.1
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 57.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 56.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 56.5
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 56.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 56.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 56.0
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 55.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 54.2
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 53.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 53.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 52.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 50.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 49.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 49.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 48.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 48.2
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 48.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 46.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 46.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 45.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 45.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 45.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 45.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 45.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 44.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 44.6
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 43.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 42.7
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 42.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 42.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 42.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 42.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 41.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 40.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 40.5
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 39.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 39.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 38.2
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 38.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 38.1
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 38.1
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 37.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 37.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 37.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 37.2
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 37.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 37.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 36.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 36.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 36.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 36.3
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 36.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 36.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 35.3
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 35.0
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 35.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 34.1
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 34.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 33.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 33.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 33.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 33.3
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 33.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 33.2
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 33.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 32.9
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 32.8
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 32.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 32.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 32.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 31.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 31.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 31.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 31.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 31.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 31.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 31.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 30.5
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 28.3
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 28.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 27.7
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 27.3
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 27.2
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 27.1
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 26.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 26.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 26.0
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 25.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 25.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 24.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 24.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 24.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 24.7
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 23.6
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 22.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 21.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 20.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 20.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 18.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 18.3
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 18.2
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 17.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 17.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 17.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 16.6
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 15.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 14.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 14.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 13.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 10.2
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 9.4
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 5.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 20.8
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 20.8
FF:10158-103A5 76 years, female 20.8

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 33.2
Pig sample Sample description nTPM
Midbrain
nTPM: 20.8
Samples: 4

Max nTPM: 26.2
Min nTPM: 13.5
Sample A Female 25.7
Sample B Female 26.2
Sample C Male 13.5
Sample D Male 17.6
Periaqueductal gray
nTPM: 24.7
Samples: 3

Max nTPM: 26.1
Min nTPM: 22.8
Sample B Female 26.1
Sample C Male 25.2
Sample D Male 22.8
Substantia nigra
nTPM: 33.3
Samples: 4

Max nTPM: 47.1
Min nTPM: 15.4
Sample A Female 44.0
Sample B Female 26.6
Sample C Male 47.1
Sample D Male 15.4
Superior colliculi
nTPM: 16.6
Samples: 4

Max nTPM: 22.6
Min nTPM: 8.2
Sample A Female 21.8
Sample B Female 8.2
Sample C Male 13.8
Sample D Male 22.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 45.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 45.3
Samples: 4

Max nTPM: 48.3
Min nTPM: 43.4
Sample A Male 44.0
Sample B Male 45.4
Sample C Female 48.3
Sample D Female 43.4

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 1.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 1.5
73616037 Antisense, RP_050818_02_H04, Mouse strain C57BL/6J (56 days, male) 1.5
71281865 Antisense, RP_050818_02_H04, Mouse strain C57BL/6J (56 days, male) 1.4

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