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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:102.3 nTPM
HPA:102.3 nTPM
GTEx:111.7 nTPM
FANTOM5:302.1 Scaled Tags Per Million
Pig:41.5 nTPM
Mouse:54.3 nTPM
Allen mouse:0.2 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 102.3
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 90.4
1870 Female, age 42, unknown 105.4
1830 Male, age 51, unknown 102.5
2411 Female, age 72, unknown 99.4
1833 Male, age 53, unknown 97.0
2019 Male, age 18, unknown 96.2
2828 Female, age 72, unknown 86.7
2666 Male, age 74, left hemisphere 82.5
2586 Male, age 75, left hemisphere 79.0
1827 Male, age 72, unknown 77.5
2219 Male, age 76, both hemispheres 77.3
Dorsal raphe nucleus
nTPM: 84.1
2750 Male, age 76, both hemispheres 99.3
2016 Female, age 72, unknown 86.4
1828 Male, age 53, unknown 82.2
2047 Male, age 72, unknown 77.7
2298 Female, age 72, unknown 74.9
Inferior colliculus
nTPM: 80.8
1848 Female, age 42, unknown 82.7
1890 Male, age 53, unknown 81.6
2097 Female, age 72, unknown 80.0
2849 Male, age 72, unknown 78.9
Median raphe nucleus
nTPM: 83.2
2220 Male, age 76, midline 83.2
Pedunculopontine tegmental nucleus
nTPM: 88.0
2338 Male, age 61, both hemispheres 93.0
2334 Male, age 80, both hemispheres 90.8
1921 Female, age 85, both hemispheres 80.2
Periaquaductal grey, anterior
nTPM: 78.3
2502 Female, age 75, unknown 84.3
1947 Male, age 18, unknown 78.2
1795 Male, age 51, unknown 72.4
Periaquaductal grey, dorsal
nTPM: 78.0
2464 Female, age 72, unknown 84.2
2850 Male, age 76, both hemispheres 78.6
1831 Male, age 72, unknown 78.2
1840 Male, age 53, unknown 70.9
Periaquaductal grey, lateral
nTPM: 78.7
2053 Male, age 18, unknown 79.6
2272 Male, age 74, both hemispheres 78.5
2140 Male, age 76, both hemispheres 77.8
Pretectal area
nTPM: 79.1
2316 Male, age 76, right hemisphere 87.0
1815 Male, age 53, unknown 86.7
1817 Female, age 42, unknown 82.3
2667 Female, age 75, unknown 79.9
2825 Male, age 18, unknown 79.3
2273 Male, age 74, both hemispheres 78.7
2407 Male, age 75, both hemispheres 78.2
2224 Female, age 72, unknown 77.4
2007 Male, age 72, unknown 77.0
1944 Female, age 72, unknown 73.5
1816 Male, age 51, unknown 69.8
Red nucleus
nTPM: 102.3
1865 Male, age 51, unknown 115.9
1904 Male, age 53, unknown 114.0
1821 Female, age 72, unknown 110.6
1954 Female, age 42, unknown 109.2
2227 Male, age 72, unknown 107.6
2769 Male, age 72, unknown 107.1
2785 Male, age 18, unknown 100.8
2503 Female, age 72, unknown 99.9
2823 Male, age 76, right hemisphere 98.7
2588 Male, age 74, left hemisphere 93.6
2725 Female, age 75, unknown 86.7
2584 Male, age 75, left hemisphere 83.1
Substantia nigra
nTPM: 84.1
2409 Female, age 72, unknown 90.0
1851 Male, age 51, unknown 88.4
2699 Male, age 18, unknown 88.2
2590 Female, age 75, unknown 86.4
2241 Male, age 72, unknown 84.0
1889 Female, age 72, unknown 83.9
2583 Male, age 75, right hemisphere 82.8
2665 Male, age 74, both hemispheres 81.0
1941 Male, age 53, unknown 78.8
1916 Female, age 42, unknown 77.3
Superior colliculus
nTPM: 85.3
1913 Female, age 42, unknown 104.6
1995 Male, age 72, unknown 100.4
2587 Male, age 74, left hemisphere 88.9
1839 Male, age 51, unknown 85.6
2668 Female, age 75, unknown 85.1
1895 Male, age 76, right hemisphere 84.3
1796 Male, age 53, unknown 78.5
2664 Male, age 75, both hemispheres 76.2
2087 Female, age 72, unknown 75.5
2261 Male, age 18, unknown 74.1
Ventral tegmental area
nTPM: 90.3
2223 Female, age 72, unknown 107.6
2410 Female, age 72, unknown 97.7
2021 Male, age 53, unknown 87.5
1942 Male, age 51, unknown 83.6
2218 Male, age 76, both hemispheres 83.1
1915 Female, age 42, unknown 82.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 111.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 111.7
Samples: 139

Max nTPM: 252.3
Min nTPM: 37.6
Std nTPM: 36.2
Median nTPM: 108.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 252.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 216.8
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 203.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 188.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 180.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 177.7
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 172.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 172.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 170.9
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 167.1
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 165.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 163.7
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 161.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 159.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 157.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 156.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 156.3
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 155.9
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 155.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 150.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 149.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 149.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 149.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 148.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 148.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 147.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 145.4
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 143.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 142.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 142.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 139.3
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 138.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 136.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 136.1
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 134.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 132.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 129.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 128.5
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 128.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 128.0
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 128.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 125.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 125.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 124.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 123.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 123.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 122.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 122.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 121.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 120.4
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 120.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 118.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 117.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 117.7
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 117.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 116.9
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 115.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 115.1
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 115.0
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 114.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 113.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 113.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 113.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 112.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 112.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 111.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 109.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 108.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 108.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 108.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 107.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 105.0
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 104.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 102.8
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 102.7
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 102.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 102.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 102.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 102.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 101.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 100.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 99.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 99.6
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 98.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 97.6
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 95.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 95.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 94.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 93.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 93.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 92.9
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 92.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 92.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 90.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 90.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 90.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 89.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 88.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 88.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 88.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 87.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 87.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 87.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 84.9
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 84.1
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 83.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 83.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 83.0
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 81.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 80.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 80.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 80.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 79.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 79.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 78.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 78.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 77.8
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 77.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 76.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 76.3
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 76.3
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 74.9
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 74.7
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 73.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 71.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 69.6
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 69.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 68.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 66.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 62.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 62.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 60.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 60.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 58.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 58.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 56.7
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 54.6
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 41.2
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 37.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 302.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 302.1
FF:10158-103A5 76 years, female 302.1

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 41.5
Pig sample Sample description nTPM
Midbrain
nTPM: 41.5
Samples: 4

Max nTPM: 84.5
Min nTPM: 21.7
Sample A Female 84.5
Sample B Female 35.8
Sample C Male 23.8
Sample D Male 21.7
Periaqueductal gray
nTPM: 28.9
Samples: 3

Max nTPM: 33.7
Min nTPM: 26.0
Sample B Female 33.7
Sample C Male 26.0
Sample D Male 26.9
Substantia nigra
nTPM: 39.9
Samples: 4

Max nTPM: 47.1
Min nTPM: 31.2
Sample A Female 44.7
Sample B Female 36.4
Sample C Male 31.2
Sample D Male 47.1
Superior colliculi
nTPM: 38.0
Samples: 4

Max nTPM: 46.6
Min nTPM: 31.3
Sample A Female 46.6
Sample B Female 39.2
Sample C Male 31.3
Sample D Male 34.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 54.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 54.4
Samples: 4

Max nTPM: 57.5
Min nTPM: 51.4
Sample A Male 55.5
Sample B Male 51.4
Sample C Female 53.0
Sample D Female 57.5

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.2
71378603 Antisense, RP_050517_02_A01, Mouse strain C57BL/6J (56 days, male) 0.2
70919812 Antisense, RP_050713_02_B02, Mouse strain C57BL/6J (56 days, male) 0.1

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