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FOXP3
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  • FOXP3
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

FOXP3
Synonyms AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID
Gene descriptioni

Full gene name according to HGNC.

Forkhead box P3
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
Transcription factors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome X
Cytoband p11.23
Chromosome location (bp) 49250438 - 49270477
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

8
Ensembl ENSG00000049768 (version 103.38)
Entrez gene 50943
HGNC HGNC:6106
UniProt Q9BZS1 (UniProt - Evidence at protein level)
neXtProt NX_Q9BZS1
Antibodypedia FOXP3 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 10      # Population variants: 148

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
FOXP3-201
FOXP3-202
FOXP3-203
FOXP3-204
FOXP3-205
FOXP3-206
FOXP3-207
FOXP3-209


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
FOXP3-201
ENSP00000365369
ENST00000376197
A0A0C4DFW6 [Direct mapping]
Forkhead box P3, isoform CRA_b; Forkhead box protein P3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Show all
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
441 aa
48.4 kDa
No 0
FOXP3-202
ENSP00000365372
ENST00000376199
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001818 [negative regulation of cytokine production]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002667 [regulation of T cell anergy]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009615 [response to virus]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0032991 [protein-containing complex]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045589 [regulation of regulatory T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050777 [negative regulation of immune response]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
396 aa
43.4 kDa
No 0
FOXP3-203
ENSP00000365380
ENST00000376207
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001818 [negative regulation of cytokine production]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002667 [regulation of T cell anergy]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009615 [response to virus]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0032991 [protein-containing complex]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045589 [regulation of regulatory T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050777 [negative regulation of immune response]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
431 aa
47.2 kDa
No 0
FOXP3-204
ENSP00000396415
ENST00000455775
B7ZLG1 [Direct mapping]
FOXP3 protein; Forkhead box protein P3
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Show all
GO:0002361 [CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
454 aa
49.7 kDa
No 0
FOXP3-205
ENSP00000428952
ENST00000518685
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001818 [negative regulation of cytokine production]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002667 [regulation of T cell anergy]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009615 [response to virus]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0032991 [protein-containing complex]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045589 [regulation of regulatory T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0050777 [negative regulation of immune response]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
404 aa
44.4 kDa
No 0
FOXP3-206
ENSP00000451208
ENST00000557224
Q9BZS1 [Direct mapping]
Forkhead box protein P3 Forkhead box protein P3, C-terminally processed Forkhead box protein P3 41 kDa form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Helix-turn-helix domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001782 [B cell homeostasis]
GO:0001818 [negative regulation of cytokine production]
GO:0002262 [myeloid cell homeostasis]
GO:0002362 [CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment]
GO:0002456 [T cell mediated immunity]
GO:0002507 [tolerance induction]
GO:0002513 [tolerance induction to self antigen]
GO:0002637 [regulation of immunoglobulin production]
GO:0002666 [positive regulation of T cell tolerance induction]
GO:0002667 [regulation of T cell anergy]
GO:0002669 [positive regulation of T cell anergy]
GO:0002677 [negative regulation of chronic inflammatory response]
GO:0002725 [negative regulation of T cell cytokine production]
GO:0002851 [positive regulation of peripheral T cell tolerance induction]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009615 [response to virus]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030111 [regulation of Wnt signaling pathway]
GO:0031064 [negative regulation of histone deacetylation]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032496 [response to lipopolysaccharide]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032714 [negative regulation of interleukin-5 production]
GO:0032715 [negative regulation of interleukin-6 production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032831 [positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation]
GO:0032914 [positive regulation of transforming growth factor beta1 production]
GO:0032991 [protein-containing complex]
GO:0033092 [positive regulation of immature T cell proliferation in thymus]
GO:0035035 [histone acetyltransferase binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0035067 [negative regulation of histone acetylation]
GO:0042110 [T cell activation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043029 [T cell homeostasis]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045589 [regulation of regulatory T cell differentiation]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046007 [negative regulation of activated T cell proliferation]
GO:0046872 [metal ion binding]
GO:0048294 [negative regulation of isotype switching to IgE isotypes]
GO:0048302 [regulation of isotype switching to IgG isotypes]
GO:0050672 [negative regulation of lymphocyte proliferation]
GO:0050728 [negative regulation of inflammatory response]
GO:0050777 [negative regulation of immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0051525 [NFAT protein binding]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000320 [negative regulation of T-helper 17 cell differentiation]
Show all
456 aa
49.8 kDa
No 0
FOXP3-207
ENSP00000499100
ENST00000650877
A0A494C1K1 [Direct mapping]
Forkhead box protein P3
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Show all
54 aa
5.3 kDa
No 0
FOXP3-209
ENSP00000498236
ENST00000652559
A0A494BZV0 [Direct mapping]
Forkhead box protein P3
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
   Immune system diseases
   Primary immunodeficiency
Show all
154 aa
15.7 kDa
No 0

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