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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:58.4 nTPM
HPA:58.4 nTPM
GTEx:38.0 nTPM
FANTOM5:62.1 Scaled Tags Per Million
Pig:92.2 nTPM
Mouse:165.4 nTPM
Allen mouse:3.1 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 58.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 41.0
1870 Female, age 42, unknown 52.4
2411 Female, age 72, unknown 49.3
2828 Female, age 72, unknown 46.2
1827 Male, age 72, unknown 45.0
1830 Male, age 51, unknown 44.6
1833 Male, age 53, unknown 42.8
2666 Male, age 74, left hemisphere 37.0
2586 Male, age 75, left hemisphere 32.2
2219 Male, age 76, both hemispheres 31.2
2019 Male, age 18, unknown 29.4
Dorsal raphe nucleus
nTPM: 48.8
2750 Male, age 76, both hemispheres 57.2
2298 Female, age 72, unknown 55.9
2047 Male, age 72, unknown 53.9
1828 Male, age 53, unknown 41.2
2016 Female, age 72, unknown 35.9
Inferior colliculus
nTPM: 40.7
1848 Female, age 42, unknown 44.7
2097 Female, age 72, unknown 40.6
2849 Male, age 72, unknown 39.9
1890 Male, age 53, unknown 37.4
Median raphe nucleus
nTPM: 58.4
2220 Male, age 76, midline 58.4
Pedunculopontine tegmental nucleus
nTPM: 47.2
2334 Male, age 80, both hemispheres 54.3
1921 Female, age 85, both hemispheres 51.7
2338 Male, age 61, both hemispheres 35.8
Periaquaductal grey, anterior
nTPM: 53.0
1947 Male, age 18, unknown 59.8
2502 Female, age 75, unknown 52.8
1795 Male, age 51, unknown 46.3
Periaquaductal grey, dorsal
nTPM: 43.2
2850 Male, age 76, both hemispheres 50.8
2464 Female, age 72, unknown 44.1
1831 Male, age 72, unknown 39.6
1840 Male, age 53, unknown 38.2
Periaquaductal grey, lateral
nTPM: 44.3
2053 Male, age 18, unknown 48.2
2140 Male, age 76, both hemispheres 42.8
2272 Male, age 74, both hemispheres 41.8
Pretectal area
nTPM: 42.5
2667 Female, age 75, unknown 51.6
2825 Male, age 18, unknown 49.4
2224 Female, age 72, unknown 48.7
2273 Male, age 74, both hemispheres 43.7
1815 Male, age 53, unknown 43.6
2316 Male, age 76, right hemisphere 40.9
1817 Female, age 42, unknown 39.5
1816 Male, age 51, unknown 39.2
2007 Male, age 72, unknown 38.2
1944 Female, age 72, unknown 37.2
2407 Male, age 75, both hemispheres 35.6
Red nucleus
nTPM: 37.2
1865 Male, age 51, unknown 46.9
2725 Female, age 75, unknown 46.6
1821 Female, age 72, unknown 44.3
1954 Female, age 42, unknown 40.3
1904 Male, age 53, unknown 38.2
2503 Female, age 72, unknown 36.1
2227 Male, age 72, unknown 36.0
2769 Male, age 72, unknown 35.2
2823 Male, age 76, right hemisphere 34.1
2588 Male, age 74, left hemisphere 33.0
2785 Male, age 18, unknown 31.8
2584 Male, age 75, left hemisphere 24.1
Substantia nigra
nTPM: 31.3
1916 Female, age 42, unknown 44.4
1941 Male, age 53, unknown 38.8
1889 Female, age 72, unknown 37.0
2241 Male, age 72, unknown 34.1
2665 Male, age 74, both hemispheres 30.7
2699 Male, age 18, unknown 29.6
1851 Male, age 51, unknown 27.2
2583 Male, age 75, right hemisphere 24.9
2590 Female, age 75, unknown 24.2
2409 Female, age 72, unknown 22.1
Superior colliculus
nTPM: 42.2
2664 Male, age 75, both hemispheres 49.4
2261 Male, age 18, unknown 48.3
1839 Male, age 51, unknown 47.6
2587 Male, age 74, left hemisphere 43.4
1895 Male, age 76, right hemisphere 42.8
2087 Female, age 72, unknown 41.2
1796 Male, age 53, unknown 39.0
1913 Female, age 42, unknown 37.8
1995 Male, age 72, unknown 37.3
2668 Female, age 75, unknown 35.0
Ventral tegmental area
nTPM: 42.3
2223 Female, age 72, unknown 53.6
2218 Male, age 76, both hemispheres 44.7
2021 Male, age 53, unknown 41.9
2410 Female, age 72, unknown 40.3
1915 Female, age 42, unknown 37.8
1942 Male, age 51, unknown 35.5

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 38.0
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 38.0
Samples: 139

Max nTPM: 133.5
Min nTPM: 12.4
Std nTPM: 19.5
Median nTPM: 32.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 133.5
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 102.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 92.4
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 85.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 81.5
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 77.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 76.5
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 75.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 74.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 71.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 69.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 67.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 63.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 61.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 61.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 60.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 59.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 59.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 59.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 57.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 56.8
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 56.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 56.6
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 55.7
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 55.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 54.3
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 52.9
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 52.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 52.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 51.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 49.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 49.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 49.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 48.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 47.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 46.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 46.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 46.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 46.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 45.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 44.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 42.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 42.0
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 41.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 40.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 40.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 40.3
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 40.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 39.1
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 39.1
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 39.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 38.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 38.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 38.2
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 38.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 38.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 37.0
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 36.7
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 36.6
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 36.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 35.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 35.7
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 34.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 34.6
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 33.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 33.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 33.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 33.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 33.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 32.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 32.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 32.0
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 31.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 31.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 31.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 30.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 30.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 30.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 29.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 29.2
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 29.1
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 28.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 28.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 28.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 28.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 27.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 27.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 27.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 27.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 27.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 27.2
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 27.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 27.2
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 27.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 26.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 26.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 26.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 26.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 26.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 26.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 26.1
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 25.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 25.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 24.9
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 24.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 24.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 24.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 24.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 23.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 23.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 23.2
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 23.1
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 22.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 22.3
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 21.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 20.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 20.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 20.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 20.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 20.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 20.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 19.9
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 19.3
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 19.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 19.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 19.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 18.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 18.4
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 18.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 17.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 17.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 16.4
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 16.1
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 15.5
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 14.8
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 13.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 13.4
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 12.7
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 12.4
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 62.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 62.1
FF:10158-103A5 76 years, female 62.1

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 92.2
Pig sample Sample description nTPM
Midbrain
nTPM: 92.2
Samples: 4

Max nTPM: 154.4
Min nTPM: 52.0
Sample A Female 154.4
Sample B Female 99.5
Sample C Male 63.0
Sample D Male 52.0
Periaqueductal gray
nTPM: 78.4
Samples: 3

Max nTPM: 85.8
Min nTPM: 69.3
Sample B Female 85.8
Sample C Male 80.0
Sample D Male 69.3
Substantia nigra
nTPM: 72.8
Samples: 4

Max nTPM: 104.2
Min nTPM: 58.2
Sample A Female 104.2
Sample B Female 58.2
Sample C Male 68.1
Sample D Male 60.6
Superior colliculi
nTPM: 61.1
Samples: 4

Max nTPM: 67.0
Min nTPM: 48.4
Sample A Female 64.4
Sample B Female 48.4
Sample C Male 67.0
Sample D Male 64.4

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 165.4
Mouse sample Sample description nTPM
Midbrain
nTPM: 165.4
Samples: 4

Max nTPM: 171.6
Min nTPM: 157.7
Sample A Male 171.6
Sample B Male 168.3
Sample C Female 157.7
Sample D Female 164.1

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.1
70439123 Antisense, RP_050614_03_C01, Mouse strain C57BL/6J (56 days, male) 3.5
74750020 Antisense, RP_060220_05_E10, Mouse strain C57BL/6J (56 days, male) 2.7

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