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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p21.31
Chromosome location (bp)
49359139 - 49412998
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
RHOA-202
RHOA-203
RHOA-205
RHOA-206
RHOA-207
RHOA-209
RHOA-210
RHOA-211
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P61586 [Direct mapping] Transforming protein RhoA A0A024R324 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Congenital malformations Congenital malformations of skin Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0007015 [actin filament organization] GO:0007049 [cell cycle] GO:0007163 [establishment or maintenance of cell polarity] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0008360 [regulation of cell shape] GO:0010812 [negative regulation of cell-substrate adhesion] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016477 [cell migration] GO:0016579 [protein deubiquitination] GO:0016787 [hydrolase activity] GO:0017022 [myosin binding] GO:0019901 [protein kinase binding] GO:0021762 [substantia nigra development] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0030054 [cell junction] GO:0030334 [regulation of cell migration] GO:0030425 [dendrite] GO:0030496 [midbody] GO:0030667 [secretory granule membrane] GO:0030865 [cortical cytoskeleton organization] GO:0031122 [cytoplasmic microtubule organization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031410 [cytoplasmic vesicle] GO:0031532 [actin cytoskeleton reorganization] GO:0031982 [vesicle] GO:0032154 [cleavage furrow] GO:0032467 [positive regulation of cytokinesis] GO:0032956 [regulation of actin cytoskeleton organization] GO:0033688 [regulation of osteoblast proliferation] GO:0034329 [cell junction assembly] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035385 [Roundabout signaling pathway] GO:0036089 [cleavage furrow formation] GO:0038027 [apolipoprotein A-I-mediated signaling pathway] GO:0042995 [cell projection] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043149 [stress fiber assembly] GO:0043197 [dendritic spine] GO:0043231 [intracellular membrane-bounded organelle] GO:0043296 [apical junction complex] GO:0043297 [apical junction assembly] GO:0043312 [neutrophil degranulation] GO:0043542 [endothelial cell migration] GO:0043931 [ossification involved in bone maturation] GO:0044319 [wound healing, spreading of cells] GO:0045198 [establishment of epithelial cell apical/basal polarity] GO:0045666 [positive regulation of neuron differentiation] GO:0045792 [negative regulation of cell size] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050771 [negative regulation of axonogenesis] GO:0050772 [positive regulation of axonogenesis] GO:0050919 [negative chemotaxis] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0051301 [cell division] GO:0051496 [positive regulation of stress fiber assembly] GO:0051893 [regulation of focal adhesion assembly] GO:0060071 [Wnt signaling pathway, planar cell polarity pathway] GO:0060193 [positive regulation of lipase activity] GO:0061383 [trabecula morphogenesis] GO:0070062 [extracellular exosome] GO:0071222 [cellular response to lipopolysaccharide] GO:0071345 [cellular response to cytokine stimulus] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0071944 [cell periphery] GO:0090051 [negative regulation of cell migration involved in sprouting angiogenesis] GO:0090307 [mitotic spindle assembly] GO:0097498 [endothelial tube lumen extension] GO:0098794 [postsynapse] GO:0098978 [glutamatergic synapse] GO:0101003 [ficolin-1-rich granule membrane] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1902766 [skeletal muscle satellite cell migration] GO:1903673 [mitotic cleavage furrow formation] GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell] GO:1905274 [regulation of modification of postsynaptic actin cytoskeleton] GO:1990869 [cellular response to chemokine] GO:2000145 [regulation of cell motility] GO:2000406 [positive regulation of T cell migration]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
C9JNR4 [Direct mapping] Transforming protein RhoA A0A024R324 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
A0A024R324 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
A0A024R324 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; Ras homolog gene family, member A, isoform CRA_a
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Congenital malformations Congenital malformations of skin Protein evidence (Ezkurdia et al 2014)
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GO:0000902 [cell morphogenesis] GO:0001666 [response to hypoxia] GO:0001998 [angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure] GO:0002363 [alpha-beta T cell lineage commitment] GO:0003100 [regulation of systemic arterial blood pressure by endothelin] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007010 [cytoskeleton organization] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0007519 [skeletal muscle tissue development] GO:0008064 [regulation of actin polymerization or depolymerization] GO:0009612 [response to mechanical stimulus] GO:0009749 [response to glucose] GO:0010812 [negative regulation of cell-substrate adhesion] GO:0010975 [regulation of neuron projection development] GO:0010977 [negative regulation of neuron projection development] GO:0016020 [membrane] GO:0019003 [GDP binding] GO:0019904 [protein domain specific binding] GO:0021795 [cerebral cortex cell migration] GO:0021861 [forebrain radial glial cell differentiation] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0030154 [cell differentiation] GO:0030307 [positive regulation of cell growth] GO:0030335 [positive regulation of cell migration] GO:0030424 [axon] GO:0030521 [androgen receptor signaling pathway] GO:0030838 [positive regulation of actin filament polymerization] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0032587 [ruffle membrane] GO:0032956 [regulation of actin cytoskeleton organization] GO:0033144 [negative regulation of intracellular steroid hormone receptor signaling pathway] GO:0033688 [regulation of osteoblast proliferation] GO:0042476 [odontogenesis] GO:0042493 [response to drug] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043149 [stress fiber assembly] GO:0043200 [response to amino acid] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043297 [apical junction assembly] GO:0043366 [beta selection] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043931 [ossification involved in bone maturation] GO:0044319 [wound healing, spreading of cells] GO:0045471 [response to ethanol] GO:0045665 [negative regulation of neuron differentiation] GO:0045727 [positive regulation of translation] GO:0045785 [positive regulation of cell adhesion] GO:0045907 [positive regulation of vasoconstriction] GO:0045987 [positive regulation of smooth muscle contraction] GO:0046039 [GTP metabolic process] GO:0046638 [positive regulation of alpha-beta T cell differentiation] GO:0048812 [neuron projection morphogenesis] GO:0050773 [regulation of dendrite development] GO:0051022 [Rho GDP-dissociation inhibitor binding] GO:0051384 [response to glucocorticoid] GO:0051924 [regulation of calcium ion transport] GO:0060548 [negative regulation of cell death] GO:0061383 [trabecula morphogenesis] GO:0070507 [regulation of microtubule cytoskeleton organization] GO:0071803 [positive regulation of podosome assembly] GO:0090324 [negative regulation of oxidative phosphorylation] GO:1902766 [skeletal muscle satellite cell migration] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1904695 [positive regulation of vascular associated smooth muscle contraction] GO:1905244 [regulation of modification of synaptic structure] GO:2000177 [regulation of neural precursor cell proliferation]
The Human Protein Atlas project is funded
