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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
q11.1
Chromosome location (bp)
20946906 - 21111813
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ROCK1-201
ROCK1-202
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q13464 [Direct mapping] Rho-associated protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0000281 [mitotic cytokinesis] GO:0001726 [ruffle] GO:0003180 [aortic valve morphogenesis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006939 [smooth muscle contraction] GO:0007159 [leukocyte cell-cell adhesion] GO:0007165 [signal transduction] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0007266 [Rho protein signal transduction] GO:0010494 [cytoplasmic stress granule] GO:0010506 [regulation of autophagy] GO:0010508 [positive regulation of autophagy] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010628 [positive regulation of gene expression] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016525 [negative regulation of angiogenesis] GO:0016740 [transferase activity] GO:0017048 [Rho GTPase binding] GO:0017049 [GTP-Rho binding] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019828 [aspartic-type endopeptidase inhibitor activity] GO:0022614 [membrane to membrane docking] GO:0030027 [lamellipodium] GO:0030036 [actin cytoskeleton organization] GO:0030155 [regulation of cell adhesion] GO:0030334 [regulation of cell migration] GO:0030866 [cortical actin cytoskeleton organization] GO:0031032 [actomyosin structure organization] GO:0031175 [neuron projection development] GO:0031267 [small GTPase binding] GO:0032059 [bleb] GO:0032091 [negative regulation of protein binding] GO:0032956 [regulation of actin cytoskeleton organization] GO:0034774 [secretory granule lumen] GO:0035509 [negative regulation of myosin-light-chain-phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0042326 [negative regulation of phosphorylation] GO:0042995 [cell projection] GO:0043312 [neutrophil degranulation] GO:0043410 [positive regulation of MAPK cascade] GO:0045616 [regulation of keratinocyte differentiation] GO:0045664 [regulation of neuron differentiation] GO:0046872 [metal ion binding] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048156 [tau protein binding] GO:0048598 [embryonic morphogenesis] GO:0050321 [tau-protein kinase activity] GO:0050900 [leukocyte migration] GO:0050901 [leukocyte tethering or rolling] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] GO:0051451 [myoblast migration] GO:0051492 [regulation of stress fiber assembly] GO:0051893 [regulation of focal adhesion assembly] GO:0051894 [positive regulation of focal adhesion assembly] GO:0061157 [mRNA destabilization] GO:0070168 [negative regulation of biomineral tissue development] GO:0070507 [regulation of microtubule cytoskeleton organization] GO:0071559 [response to transforming growth factor beta] GO:0072518 [Rho-dependent protein serine/threonine kinase activity] GO:0072659 [protein localization to plasma membrane] GO:0090521 [glomerular visceral epithelial cell migration] GO:0097746 [regulation of blood vessel diameter] GO:0106003 [amyloid-beta complex] GO:0106310 [] GO:0106311 [] GO:0110061 [regulation of angiotensin-activated signaling pathway] GO:0140058 [neuron projection arborization] GO:1900223 [positive regulation of amyloid-beta clearance] GO:1900242 [regulation of synaptic vesicle endocytosis] GO:1901888 [regulation of cell junction assembly] GO:1902003 [regulation of amyloid-beta formation] GO:1902430 [negative regulation of amyloid-beta formation] GO:1902992 [negative regulation of amyloid precursor protein catabolic process] GO:1903140 [regulation of establishment of endothelial barrier] GO:1903347 [negative regulation of bicellular tight junction assembly] GO:1905205 [positive regulation of connective tissue replacement] GO:1990776 [response to angiotensin] GO:2000114 [regulation of establishment of cell polarity] GO:2000145 [regulation of cell motility]