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SIRT2
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  • SIRT2
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

SIRT2
Synonyms SIR2L
Gene descriptioni

Full gene name according to HGNC.

Sirtuin 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Enzymes
Metabolic proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 19
Cytoband q13.2
Chromosome location (bp) 38878555 - 38899862
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

9
Ensembl ENSG00000068903 (version 103.38)
Entrez gene 22933
HGNC HGNC:10886
UniProt Q8IXJ6 (UniProt - Evidence at protein level)
neXtProt NX_Q8IXJ6
Antibodypedia SIRT2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 259

Experimental

Description: HUMAN SIRT2 HISTONE DEACETYLASE (X-ray)

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
SIRT2-201
SIRT2-202
SIRT2-203
SIRT2-204
SIRT2-205
SIRT2-206
SIRT2-209
SIRT2-211
SIRT2-219


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
SIRT2-201
ENSP00000249396
ENST00000249396
Q8IXJ6 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000183 [rDNA heterochromatin assembly]
GO:0000781 [chromosome, telomeric region]
GO:0000792 [heterochromatin]
GO:0002376 [immune system process]
GO:0003682 [chromatin binding]
GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005677 [chromatin silencing complex]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006342 [chromatin silencing]
GO:0006348 [chromatin silencing at telomere]
GO:0006471 [protein ADP-ribosylation]
GO:0006476 [protein deacetylation]
GO:0006914 [autophagy]
GO:0007049 [cell cycle]
GO:0007096 [regulation of exit from mitosis]
GO:0007399 [nervous system development]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0016740 [transferase activity]
GO:0017136 [NAD-dependent histone deacetylase activity]
GO:0021762 [substantia nigra development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030154 [cell differentiation]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0031641 [regulation of myelination]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033010 [paranodal junction]
GO:0033270 [paranode region of axon]
GO:0033558 [protein deacetylase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0034979 [NAD-dependent protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035035 [histone acetyltransferase binding]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042325 [regulation of phosphorylation]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0042995 [cell projection]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043204 [perikaryon]
GO:0043209 [myelin sheath]
GO:0043219 [lateral loop]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043388 [positive regulation of DNA binding]
GO:0043491 [protein kinase B signaling]
GO:0044224 [juxtaparanode region of axon]
GO:0044242 [cellular lipid catabolic process]
GO:0045087 [innate immune response]
GO:0045598 [regulation of fat cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045836 [positive regulation of meiotic nuclear division]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046970 [NAD-dependent histone deacetylase activity (H4-K16 specific)]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051781 [positive regulation of cell division]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061433 [cellular response to caloric restriction]
GO:0070403 [NAD+ binding]
GO:0070446 [negative regulation of oligodendrocyte progenitor proliferation]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0071219 [cellular response to molecule of bacterial origin]
GO:0071456 [cellular response to hypoxia]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0072686 [mitotic spindle]
GO:0072687 [meiotic spindle]
GO:0090042 [tubulin deacetylation]
GO:0097386 [glial cell projection]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900195 [positive regulation of oocyte maturation]
GO:1900226 [negative regulation of NLRP3 inflammasome complex assembly]
GO:1900425 [negative regulation of defense response to bacterium]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000777 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia]
Show all
389 aa
43.2 kDa
No 0
SIRT2-202
ENSP00000351809
ENST00000358931
A0A0A0MRF5 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
234 aa
26.7 kDa
No 0
SIRT2-203
ENSP00000401203
ENST00000381766
C9JZQ0 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
130 aa
15.1 kDa
No 0
SIRT2-204
ENSP00000375931
ENST00000392081
Q8IXJ6 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
A0A024R0G8 [Target identity:100%; Query identity:100%]
NAD-dependent protein deacetylase
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000183 [rDNA heterochromatin assembly]
GO:0000781 [chromosome, telomeric region]
GO:0000792 [heterochromatin]
GO:0002376 [immune system process]
GO:0003682 [chromatin binding]
GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005677 [chromatin silencing complex]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006342 [chromatin silencing]
GO:0006348 [chromatin silencing at telomere]
GO:0006471 [protein ADP-ribosylation]
GO:0006476 [protein deacetylation]
GO:0006914 [autophagy]
GO:0007049 [cell cycle]
GO:0007096 [regulation of exit from mitosis]
GO:0007399 [nervous system development]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0010507 [negative regulation of autophagy]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016575 [histone deacetylation]
GO:0016740 [transferase activity]
GO:0017136 [NAD-dependent histone deacetylase activity]
GO:0021762 [substantia nigra development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030154 [cell differentiation]
GO:0030426 [growth cone]
GO:0030496 [midbody]
GO:0031641 [regulation of myelination]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0033010 [paranodal junction]
GO:0033270 [paranode region of axon]
GO:0033558 [protein deacetylase activity]
GO:0034599 [cellular response to oxidative stress]
GO:0034979 [NAD-dependent protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035035 [histone acetyltransferase binding]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042325 [regulation of phosphorylation]
GO:0042826 [histone deacetylase binding]
GO:0042903 [tubulin deacetylase activity]
GO:0042995 [cell projection]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043204 [perikaryon]
GO:0043209 [myelin sheath]
GO:0043219 [lateral loop]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043388 [positive regulation of DNA binding]
GO:0043491 [protein kinase B signaling]
GO:0044224 [juxtaparanode region of axon]
GO:0044242 [cellular lipid catabolic process]
GO:0045087 [innate immune response]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045836 [positive regulation of meiotic nuclear division]
GO:0045843 [negative regulation of striated muscle tissue development]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0046970 [NAD-dependent histone deacetylase activity (H4-K16 specific)]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051301 [cell division]
GO:0051321 [meiotic cell cycle]
GO:0051726 [regulation of cell cycle]
GO:0051775 [response to redox state]
GO:0051781 [positive regulation of cell division]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0061428 [negative regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061433 [cellular response to caloric restriction]
GO:0070403 [NAD+ binding]
GO:0070446 [negative regulation of oligodendrocyte progenitor proliferation]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0071219 [cellular response to molecule of bacterial origin]
GO:0071456 [cellular response to hypoxia]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0072686 [mitotic spindle]
GO:0072687 [meiotic spindle]
GO:0090042 [tubulin deacetylation]
GO:0097386 [glial cell projection]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900195 [positive regulation of oocyte maturation]
GO:1900425 [negative regulation of defense response to bacterium]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000777 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia]
Show all
352 aa
39.5 kDa
No 0
SIRT2-205
ENSP00000385146
ENST00000407552
B5MCS1 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
169 aa
19.5 kDa
No 0
SIRT2-206
ENSP00000404309
ENST00000414941
E7EWX6 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Metabolic proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
237 aa
27.1 kDa
No 0
SIRT2-209
ENSP00000397022
ENST00000437828
C9J3U7 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
78 aa
8.8 kDa
No 0
SIRT2-211
ENSP00000408023
ENST00000447739
C9JR33 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
73 aa
8.2 kDa
No 0
SIRT2-219
ENSP00000481932
ENST00000613542
A0A087WYM3 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-2
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
389 aa
43.3 kDa
No 0

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  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.