MOUSE BRAIN TISSUE
Gene description Nucleobindin 2
Mouse gene ENSMUSG00000030659 (version 10)
Annotation summary Nucleobindin 2 (NUCB2) is a calcium-binding protein with predominant expression in the pituitary gland in both human and mouse, although it is additionally seen across many other human organs too. In the mouse brain, moderate-intensity cytoplasmic somatic neuronal immunostaining is noticed in the lateral septum, caudate putamen, hippocampus CA2, piriform cortex, throughout the entire neocortex and amygdala nuclei. Strong intensity cytoplasmic somatic neuronal immunostaining is noticed in the hypothalamic paraventricular nucleus, supraoptic nucelus, arcuate nucleus, in the locus coeruleus, thalamic parafascicular nucleus, dorsal raphe and in the laterodorsal tegmental nucleus. Area postrema cells are also immunoreactive.
Positive cells and structuresi Soma in neurons.
Circumventricular organs of ependymal cells.
FRONT BACK
Basal ganglia
Hypothalamus
Hippocampus
Amygdala
Hypothalamus
Protein
Relative fluorescence intensityi
Mouse brain region
255
0
Cerebral cortex
Frontal association cortex (fra) N/A
Motor cortex (m)
Cingulate cortex (cg)
Piriform cortex, L1 (pirl1)
Piriform cortex, L2 (pirl2)
Piriform cortex, L3 (pirl3)
Insular cortex (i)
Somatosensory cortex (s) N/A
Retrosplenial granular cortex (rsg)
Parietal association cortex (p)
Entorhinal cortex (ent)
Visual cortex (v)
Olfactory bulb
Anterior olfactory nucleus (aon)
Granule cell layer (gro)
Internal plexiform layer (ipl)
Mitral cell layer (mi)
Glomerular layer (gl)
Rostral migratory stream (rms)
External plexiform layer (epl)
External plexiform layer of the accessory OB (epla) N/A
Granule cell layer of the accessory OB (gra) N/A
Glomerular layer of the accessory OB (gla) N/A
Hippocampus
Polymorph layer of the dentate gyrus (podg)
Molecular layer of the dentate gyrus (modg)
Granular dentate gyrus (grdg)
CA1 - oriens layer (ca1or)
CA1 - pyramidal layer (ca1py)
CA1 - radiatum layer (ca1ra)
CA2 - oriens layer (ca2or)
CA2 - pyramidal layer (ca2py)
CA2 - radiatum layer (ca2ra)
CA3 - oriens layer (ca3or)
CA3 - pyramidal layer (ca3py)
CA3 - radiatum layer (ca3ra)
Stratum lucidum (slu)
Lacunosum moleculare (lmol)
Subiculum (sub)
Amygdala
Nucleus of the lateral olfactory tract (lot) N/A
Basal medial amygdaloid nucleus (bma)
Basal lateral amygdala* (*bla) N/A
Basal lateral amygdaloid nucleus (bla)
Cortical amygdala (aco)
Central amygdala (ce)
Medial amygdaloid nucleus (mea)
Thalamus
Medial geniculate nucleus (mg)
Parafascicular thalamic nucleus (pf)
Pregeniculate nucleus (pg)
Stria terminalis (st)
Zona incerta (zi)
Anterodorsal thalamic nucleus (ad)
Reticular thalamic nucleus (rt)
Vental anterior thalamic nucleus (va) N/A
Medial habenular nucleus (mhb)
Laterodorsal thalamic area (ld)
Paraventricular thalamic nucleus (pv)
Central medial thalamic area (cm)
Ventral lateral thalamic area (vl) N/A
Ventral medial thalamic area (vm)
Lateral habenulal nucleus (lhb)
Ventral posterior thalamus (vpt)
Anterior pretactal nucleus (apt)
Retromammillary nucleus (rm)
Hypothalamus
Dorsal tuberomammillary nucleus (dtm) N/A
Mammillary nucleus (mn)
Periventricular hypothalamic nucleus (pe)
Supraoptic nucleus (so)
Tuberal nucleus (tu)
Ventral tuberomammillary nucleus (vtm) N/A
Lateral preoptic area (lpo)
Medial preoptic area (mpo)
Suprachiasmatic nucleus (sch)
Paraventricular hypothalamic nucleus (pa)
Anterior hypothalamic area, central (ahc)
Ventral medial hypothalamic nucleus (vmh)
Ventral medial hypothalamic nucleus* (*vmh) N/A
Arcuate nucleus (arc)
Arcuate nucleus* (*arc) N/A
Peduncular part of lateral hypothalmus (plh)
Dorsal medial hypothalamic nucleus (dm)
Stria terminalis* (*st) N/A
Cerebellum
Vestibulocerebellar nucleus (vecb) N/A
Moleuclar layer of the cerebellum (cemol)
Purkinje layer of the cerebellum (cepur)
Granular layer of the cerebellum (cegr)
Pons
Barrington's nucleus (bar) N/A
Koelliker-fuse nucleus (kf) N/A
Motor tregiminal nucleus (5n)
Parabrachial nucleus (pbp)
Principle sensory trigeminal nucleus (pr5)
Locus coeruleus (lc)
Pontine nucleus (pn)
Vestibular nucleus (ve)
Pontine reticular nucleus, oral (pno)
Lateral lemniscus (ll)
Superior paraolivary nucleus (spo)
Circumventricular organs
Subcommissural organ (sco)
Subfornical organ (sfo)
Median eminence (me)
Medulla (ap)

Antibodies in assayi
CAB079781

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.