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FGF10
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  • FGF10
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

FGF10
Synonyms
Gene descriptioni

Full gene name according to HGNC.

Fibroblast growth factor 10
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
RAS pathway related proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 5
Cytoband p12
Chromosome location (bp) 44300247 - 44389706
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000070193 (version 103.38)
Entrez gene 2255
HGNC HGNC:3666
UniProt O15520 (UniProt - Evidence at protein level)
neXtProt NX_O15520
Antibodypedia FGF10 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 5      # Population variants: 93

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
FGF10-201
FGF10-202


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
FGF10-201
ENSP00000264664
ENST00000264664
O15520 [Direct mapping]
Fibroblast growth factor 10
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Congenital malformations of the digestive system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000132 [establishment of mitotic spindle orientation]
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0001656 [metanephros development]
GO:0001759 [organ induction]
GO:0001823 [mesonephros development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001974 [blood vessel remodeling]
GO:0003338 [metanephros morphogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005111 [type 2 fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0007267 [cell-cell signaling]
GO:0007368 [determination of left/right symmetry]
GO:0007431 [salivary gland development]
GO:0007435 [salivary gland morphogenesis]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008544 [epidermis development]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010838 [positive regulation of keratinocyte proliferation]
GO:0014070 [response to organic cyclic compound]
GO:0021983 [pituitary gland development]
GO:0030154 [cell differentiation]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030324 [lung development]
GO:0030334 [regulation of cell migration]
GO:0030538 [embryonic genitalia morphogenesis]
GO:0030855 [epithelial cell differentiation]
GO:0030878 [thyroid gland development]
GO:0030916 [otic vesicle formation]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031016 [pancreas development]
GO:0031069 [hair follicle morphogenesis]
GO:0031076 [embryonic camera-type eye development]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032355 [response to estradiol]
GO:0032496 [response to lipopolysaccharide]
GO:0032781 [positive regulation of ATPase activity]
GO:0032808 [lacrimal gland development]
GO:0032925 [regulation of activin receptor signaling pathway]
GO:0034394 [protein localization to cell surface]
GO:0035019 [somatic stem cell population maintenance]
GO:0035108 [limb morphogenesis]
GO:0035265 [organ growth]
GO:0042056 [chemoattractant activity]
GO:0042060 [wound healing]
GO:0042246 [tissue regeneration]
GO:0042472 [inner ear morphogenesis]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042693 [muscle cell fate commitment]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045596 [negative regulation of cell differentiation]
GO:0045739 [positive regulation of DNA repair]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046877 [regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048286 [lung alveolus development]
GO:0048514 [blood vessel morphogenesis]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048557 [embryonic digestive tract morphogenesis]
GO:0048565 [digestive tract development]
GO:0048566 [embryonic digestive tract development]
GO:0048645 [animal organ formation]
GO:0048730 [epidermis morphogenesis]
GO:0048752 [semicircular canal morphogenesis]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048807 [female genitalia morphogenesis]
GO:0048808 [male genitalia morphogenesis]
GO:0050671 [positive regulation of lymphocyte proliferation]
GO:0050673 [epithelial cell proliferation]
GO:0050674 [urothelial cell proliferation]
GO:0050677 [positive regulation of urothelial cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050872 [white fat cell differentiation]
GO:0050918 [positive chemotaxis]
GO:0050930 [induction of positive chemotaxis]
GO:0051145 [smooth muscle cell differentiation]
GO:0051549 [positive regulation of keratinocyte migration]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060019 [radial glial cell differentiation]
GO:0060054 [positive regulation of epithelial cell proliferation involved in wound healing]
GO:0060173 [limb development]
GO:0060174 [limb bud formation]
GO:0060425 [lung morphogenesis]
GO:0060428 [lung epithelium development]
GO:0060430 [lung saccule development]
GO:0060436 [bronchiole morphogenesis]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060447 [bud outgrowth involved in lung branching]
GO:0060449 [bud elongation involved in lung branching]
GO:0060496 [mesenchymal-epithelial cell signaling involved in lung development]
GO:0060510 [type II pneumocyte differentiation]
GO:0060513 [prostatic bud formation]
GO:0060541 [respiratory system development]
GO:0060594 [mammary gland specification]
GO:0060595 [fibroblast growth factor receptor signaling pathway involved in mammary gland specification]
GO:0060615 [mammary gland bud formation]
GO:0060661 [submandibular salivary gland formation]
GO:0060664 [epithelial cell proliferation involved in salivary gland morphogenesis]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0060667 [branch elongation involved in salivary gland morphogenesis]
GO:0060879 [semicircular canal fusion]
GO:0060915 [mesenchymal cell differentiation involved in lung development]
GO:0061033 [secretion by lung epithelial cell involved in lung growth]
GO:0061115 [lung proximal/distal axis specification]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070075 [tear secretion]
GO:0070352 [positive regulation of white fat cell proliferation]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070384 [Harderian gland development]
GO:0071157 [negative regulation of cell cycle arrest]
GO:0071338 [positive regulation of hair follicle cell proliferation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
208 aa
23.4 kDa
Yes 0
FGF10-202
ENSP00000426406
ENST00000513107
D6RG33 [Direct mapping]
Fibroblast growth factor 10
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of eye
   Congenital malformations of the digestive system
   Other congenital malformations
Show all
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
66 aa
7 kDa
Yes 0

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The Human Protein Atlas

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  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.