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CDC42
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  • CDC42
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

CDC42
Synonyms CDC42Hs, G25K
Gene descriptioni

Full gene name according to HGNC.

Cell division cycle 42
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
RAS pathway related proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 1
Cytoband p36.12
Chromosome location (bp) 22025511 - 22101360
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

10
Ensembl ENSG00000070831 (version 103.38)
Entrez gene 998
HGNC HGNC:1736
UniProt P60953 (UniProt - Evidence at protein level)
neXtProt NX_P60953
Antibodypedia CDC42 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 9      # Population variants: 25

Experimental

Description: CDC42HS-GDP COMPLEX (X-ray)

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CDC42-201
CDC42-202
CDC42-203
CDC42-204
CDC42-206
CDC42-207
CDC42-208
CDC42-209
CDC42-210
CDC42-211


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
CDC42-201
ENSP00000314458
ENST00000315554
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAE6 [Target identity:100%; Query identity:100%]
Cell division control protein 42 homolog
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006911 [phagocytosis, engulfment]
GO:0007015 [actin filament organization]
GO:0007030 [Golgi organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0017119 [Golgi transport complex]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031996 [thioesterase binding]
GO:0032427 [GBD domain binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0032488 [Cdc42 protein signal transduction]
GO:0032991 [protein-containing complex]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034329 [cell junction assembly]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0039694 [viral RNA genome replication]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048549 [positive regulation of pinocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051489 [regulation of filopodium assembly]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051492 [regulation of stress fiber assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051683 [establishment of Golgi localization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060997 [dendritic spine morphogenesis]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:0099563 [modification of synaptic structure]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
191 aa
21.3 kDa
No 0
CDC42-202
ENSP00000341072
ENST00000344548
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAA5 [Target identity:100%; Query identity:100%]
Cell division control protein 42 homolog
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006911 [phagocytosis, engulfment]
GO:0007015 [actin filament organization]
GO:0007030 [Golgi organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0017119 [Golgi transport complex]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031996 [thioesterase binding]
GO:0032427 [GBD domain binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0032488 [Cdc42 protein signal transduction]
GO:0032991 [protein-containing complex]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034329 [cell junction assembly]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0039694 [viral RNA genome replication]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048549 [positive regulation of pinocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051489 [regulation of filopodium assembly]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051492 [regulation of stress fiber assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051683 [establishment of Golgi localization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060997 [dendritic spine morphogenesis]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:0099563 [modification of synaptic structure]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
191 aa
21.3 kDa
No 0
CDC42-203
ENSP00000383118
ENST00000400259
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAA5 [Target identity:100%; Query identity:100%]
Cell division control protein 42 homolog
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006911 [phagocytosis, engulfment]
GO:0007015 [actin filament organization]
GO:0007030 [Golgi organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0017119 [Golgi transport complex]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031996 [thioesterase binding]
GO:0032427 [GBD domain binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0032488 [Cdc42 protein signal transduction]
GO:0032991 [protein-containing complex]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034329 [cell junction assembly]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0039694 [viral RNA genome replication]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048549 [positive regulation of pinocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051489 [regulation of filopodium assembly]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051492 [regulation of stress fiber assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051683 [establishment of Golgi localization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060997 [dendritic spine morphogenesis]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:0099563 [modification of synaptic structure]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
191 aa
21.3 kDa
No 0
CDC42-204
ENSP00000398327
ENST00000411827
Q5JYX0 [Direct mapping]
Cell division control protein 42 homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
Show all
136 aa
15.2 kDa
No 0
CDC42-206
ENSP00000497733
ENST00000648594
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAA5 [Target identity:100%; Query identity:100%]
Cell division control protein 42 homolog
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0000322 [storage vacuole]
GO:0002040 [sprouting angiogenesis]
GO:0003161 [cardiac conduction system development]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006911 [phagocytosis, engulfment]
GO:0007015 [actin filament organization]
GO:0007030 [Golgi organization]
GO:0007088 [regulation of mitotic nuclear division]
GO:0007097 [nuclear migration]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0017119 [Golgi transport complex]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030141 [secretory granule]
GO:0030154 [cell differentiation]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0030742 [GTP-dependent protein binding]
GO:0031256 [leading edge membrane]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0031996 [thioesterase binding]
GO:0032427 [GBD domain binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0032488 [Cdc42 protein signal transduction]
GO:0032991 [protein-containing complex]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034613 [cellular protein localization]
GO:0035088 [establishment or maintenance of apical/basal cell polarity]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0036336 [dendritic cell migration]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0039694 [viral RNA genome replication]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043085 [positive regulation of catalytic activity]
GO:0043197 [dendritic spine]
GO:0043393 [regulation of protein binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045177 [apical part of cell]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045335 [phagocytic vesicle]
GO:0045740 [positive regulation of DNA replication]
GO:0046330 [positive regulation of JNK cascade]
GO:0046847 [filopodium assembly]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048549 [positive regulation of pinocytosis]
GO:0048664 [neuron fate determination]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051489 [regulation of filopodium assembly]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051492 [regulation of stress fiber assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051647 [nucleus localization]
GO:0051683 [establishment of Golgi localization]
GO:0051835 [positive regulation of synapse structural plasticity]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060047 [heart contraction]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis]
GO:0060661 [submandibular salivary gland formation]
GO:0060997 [dendritic spine morphogenesis]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0071346 [cellular response to interferon-gamma]
GO:0071944 [cell periphery]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:0090135 [actin filament branching]
GO:0090316 [positive regulation of intracellular protein transport]
GO:0098685 [Schaffer collateral - CA1 synapse]
GO:0099159 [regulation of modification of postsynaptic structure]
GO:0099563 [modification of synaptic structure]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
191 aa
21.3 kDa
No 0
CDC42-207
ENSP00000499132
ENST00000651171
A0A494C1M1 [Direct mapping]
Cell division control protein 42 homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
Show all
115 aa
12.8 kDa
No 0
CDC42-208
ENSP00000498275
ENST00000652582
A0A494BZX6 [Direct mapping]
Cell division control protein 42 homolog
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0007264 [small GTPase mediated signal transduction]
Show all
156 aa
17.7 kDa
No 0
CDC42-209
ENSP00000499457
ENST00000656825
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAA5 [Target identity:100%; Query identity:100%]
Cell division control protein 42 homolog
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006911 [phagocytosis, engulfment]
GO:0007015 [actin filament organization]
GO:0007030 [Golgi organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0017119 [Golgi transport complex]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031996 [thioesterase binding]
GO:0032427 [GBD domain binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0032488 [Cdc42 protein signal transduction]
GO:0032991 [protein-containing complex]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034329 [cell junction assembly]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0039694 [viral RNA genome replication]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048549 [positive regulation of pinocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051489 [regulation of filopodium assembly]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051492 [regulation of stress fiber assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051683 [establishment of Golgi localization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060997 [dendritic spine morphogenesis]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:0099563 [modification of synaptic structure]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
191 aa
21.3 kDa
No 0
CDC42-210
ENSP00000499612
ENST00000662562
P60953 [Direct mapping]
Cell division control protein 42 homolog
A0A024RAA5 [Target identity:100%; Query identity:100%]
Cell division control protein 42 homolog
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000166 [nucleotide binding]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005813 [centrosome]
GO:0005815 [microtubule organizing center]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006911 [phagocytosis, engulfment]
GO:0007015 [actin filament organization]
GO:0007030 [Golgi organization]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0007596 [blood coagulation]
GO:0010591 [regulation of lamellipodium assembly]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0016787 [hydrolase activity]
GO:0017119 [Golgi transport complex]
GO:0019901 [protein kinase binding]
GO:0021762 [substantia nigra development]
GO:0030031 [cell projection assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030154 [cell differentiation]
GO:0030175 [filopodium]
GO:0030225 [macrophage differentiation]
GO:0030307 [positive regulation of cell growth]
GO:0030425 [dendrite]
GO:0030496 [midbody]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031996 [thioesterase binding]
GO:0032427 [GBD domain binding]
GO:0032467 [positive regulation of cytokinesis]
GO:0032488 [Cdc42 protein signal transduction]
GO:0032991 [protein-containing complex]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034329 [cell junction assembly]
GO:0035722 [interleukin-12-mediated signaling pathway]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0039694 [viral RNA genome replication]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048549 [positive regulation of pinocytosis]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051233 [spindle midzone]
GO:0051301 [cell division]
GO:0051489 [regulation of filopodium assembly]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051492 [regulation of stress fiber assembly]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051683 [establishment of Golgi localization]
GO:0051988 [regulation of attachment of spindle microtubules to kinetochore]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060997 [dendritic spine morphogenesis]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0072384 [organelle transport along microtubule]
GO:0072686 [mitotic spindle]
GO:0099563 [modification of synaptic structure]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
191 aa
21.3 kDa
No 0
CDC42-211
ENSP00000499473
ENST00000667384
A0A590UJK8 [Direct mapping]
Cell division control protein 42 homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005815 [microtubule organizing center]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030496 [midbody]
Show all
166 aa
18.5 kDa
No 0

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