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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.12
Chromosome location (bp)
14091688 - 14118084
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PRKACA-201
PRKACA-203
PRKACA-204
PRKACA-207
PRKACA-208
PRKACA-209
PRKACA-210
PRKACA-211
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P17612 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha A0A024R7J0 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit alpha
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0001669 [acrosomal vesicle] GO:0001707 [mesoderm formation] GO:0001843 [neural tube closure] GO:0002027 [regulation of heart rate] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003091 [renal water homeostasis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004679 [AMP-activated protein kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005929 [cilium] GO:0005930 [axoneme] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006397 [mRNA processing] GO:0006468 [protein phosphorylation] GO:0007596 [blood coagulation] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0010737 [protein kinase A signaling] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020 [membrane] GO:0016241 [regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030145 [manganese ion binding] GO:0031410 [cytoplasmic vesicle] GO:0031514 [motile cilium] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031594 [neuromuscular junction] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034237 [protein kinase A regulatory subunit binding] GO:0034380 [high-density lipoprotein particle assembly] GO:0034605 [cellular response to heat] GO:0034704 [calcium channel complex] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0036126 [sperm flagellum] GO:0042995 [cell projection] GO:0043197 [dendritic spine] GO:0043393 [regulation of protein binding] GO:0044853 [plasma membrane raft] GO:0045667 [regulation of osteoblast differentiation] GO:0046777 [protein autophosphorylation] GO:0046827 [positive regulation of protein export from nucleus] GO:0048240 [sperm capacitation] GO:0048471 [perinuclear region of cytoplasm] GO:0050804 [modulation of chemical synaptic transmission] GO:0051480 [regulation of cytosolic calcium ion concentration] GO:0055117 [regulation of cardiac muscle contraction] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0070062 [extracellular exosome] GO:0070613 [regulation of protein processing] GO:0071158 [positive regulation of cell cycle arrest] GO:0071333 [cellular response to glucose stimulus] GO:0071374 [cellular response to parathyroid hormone stimulus] GO:0071377 [cellular response to glucagon stimulus] GO:0071872 [cellular response to epinephrine stimulus] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097546 [ciliary base] GO:0097711 [ciliary basal body-plasma membrane docking] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning] GO:1903779 [regulation of cardiac conduction] GO:2000810 [regulation of bicellular tight junction assembly]
K7EMV1 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
P17612 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Metabolic proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001669 [acrosomal vesicle] GO:0002027 [regulation of heart rate] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003091 [renal water homeostasis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004679 [AMP-activated protein kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005929 [cilium] GO:0005930 [axoneme] GO:0005952 [cAMP-dependent protein kinase complex] GO:0006397 [mRNA processing] GO:0006468 [protein phosphorylation] GO:0007596 [blood coagulation] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0010737 [protein kinase A signaling] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0016020 [membrane] GO:0016241 [regulation of macroautophagy] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0031410 [cytoplasmic vesicle] GO:0031514 [motile cilium] GO:0031588 [nucleotide-activated protein kinase complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0034237 [protein kinase A regulatory subunit binding] GO:0034380 [high-density lipoprotein particle assembly] GO:0034605 [cellular response to heat] GO:0034704 [calcium channel complex] GO:0035584 [calcium-mediated signaling using intracellular calcium source] GO:0042995 [cell projection] GO:0043393 [regulation of protein binding] GO:0044853 [plasma membrane raft] GO:0045667 [regulation of osteoblast differentiation] GO:0048240 [sperm capacitation] GO:0048471 [perinuclear region of cytoplasm] GO:0051480 [regulation of cytosolic calcium ion concentration] GO:0055117 [regulation of cardiac muscle contraction] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0070062 [extracellular exosome] GO:0071158 [positive regulation of cell cycle arrest] GO:0071333 [cellular response to glucose stimulus] GO:0071377 [cellular response to glucagon stimulus] GO:0071872 [cellular response to epinephrine stimulus] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] GO:0097225 [sperm midpiece] GO:0097546 [ciliary base] GO:0097711 [ciliary basal body-plasma membrane docking] GO:1903779 [regulation of cardiac conduction] GO:2000810 [regulation of bicellular tight junction assembly]
K7ENJ5 [Direct mapping] cAMP-dependent protein kinase catalytic subunit alpha
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
Q15136 [Direct mapping] Protein kinase A-alpha; cAMP-dependent protein kinase catalytic subunit alpha
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Translocations Human disease related genes Congenital malformations Other congenital malformations Endocrine and metabolic diseases Adrenal gland diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
