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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q28
Chromosome location (bp)
189631389 - 189897276
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q9H3D4 [Direct mapping] Tumor protein 63 A0A0S2Z4N5 [Target identity:100%; Query identity:100%] Tumor protein 63 (p63)
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001501 [skeletal system development] GO:0001736 [establishment of planar polarity] GO:0001738 [morphogenesis of a polarized epithelium] GO:0001942 [hair follicle development] GO:0002039 [p53 binding] GO:0002064 [epithelial cell development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005791 [rough endoplasmic reticulum] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0007283 [spermatogenesis] GO:0007389 [pattern specification process] GO:0007499 [ectoderm and mesoderm interaction] GO:0007568 [aging] GO:0007569 [cell aging] GO:0008283 [cell population proliferation] GO:0008544 [epidermis development] GO:0009887 [animal organ morphogenesis] GO:0009913 [epidermal cell differentiation] GO:0009954 [proximal/distal pattern formation] GO:0010259 [multicellular organism aging] GO:0010481 [epidermal cell division] GO:0010482 [regulation of epidermal cell division] GO:0010838 [positive regulation of keratinocyte proliferation] GO:0019904 [protein domain specific binding] GO:0030154 [cell differentiation] GO:0030216 [keratinocyte differentiation] GO:0030326 [embryonic limb morphogenesis] GO:0030425 [dendrite] GO:0030850 [prostate gland development] GO:0030855 [epithelial cell differentiation] GO:0030859 [polarized epithelial cell differentiation] GO:0031069 [hair follicle morphogenesis] GO:0032502 [developmental process] GO:0032991 [protein-containing complex] GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway] GO:0035115 [embryonic forelimb morphogenesis] GO:0035116 [embryonic hindlimb morphogenesis] GO:0036342 [post-anal tail morphogenesis] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043005 [neuron projection] GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0043589 [skin morphogenesis] GO:0045617 [negative regulation of keratinocyte differentiation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0048485 [sympathetic nervous system development] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048807 [female genitalia morphogenesis] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0051402 [neuron apoptotic process] GO:0060197 [cloacal septation] GO:0060513 [prostatic bud formation] GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:0098773 [skin epidermis development] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904674 [positive regulation of somatic stem cell population maintenance] GO:1904888 [cranial skeletal system development] GO:2000271 [positive regulation of fibroblast apoptotic process] GO:2000381 [negative regulation of mesoderm development] GO:2001235 [positive regulation of apoptotic signaling pathway]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1902808 [positive regulation of cell cycle G1/S phase transition] GO:2000271 [positive regulation of fibroblast apoptotic process] GO:2000773 [negative regulation of cellular senescence]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Q9H3D4 [Direct mapping] Tumor protein 63 A0A0S2Z4N6 [Target identity:100%; Query identity:100%] Tumor protein 63 (p63)
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of face and neck Congenital malformations of the musculoskeletal system Congenital malformations of skin Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006915 [apoptotic process] GO:0007219 [Notch signaling pathway] GO:0007275 [multicellular organism development] GO:0010482 [regulation of epidermal cell division] GO:0032502 [developmental process] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0050699 [WW domain binding] GO:0051262 [protein tetramerization] GO:0061436 [establishment of skin barrier] GO:0097371 [MDM2/MDM4 family protein binding] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:2000271 [positive regulation of fibroblast apoptotic process]
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