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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Candidate cardiovascular disease genes Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p24.1
Chromosome location (bp)
12290361 - 12297194
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
EDN1-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P05305 [Direct mapping] Endothelin-1 Endothelin-1 Big endothelin-1 Q6FH53 [Target identity:100%; Query identity:100%] EDN1 protein; Endothelin 1, isoform CRA_b; cDNA FLJ75736, highly similar to Homo sapiens endothelin 1 (EDN1), mRNA
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Human disease related genes Congenital malformations Congenital malformations of the musculoskeletal system Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001501 [skeletal system development] GO:0001516 [prostaglandin biosynthetic process] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001821 [histamine secretion] GO:0003100 [regulation of systemic arterial blood pressure by endothelin] GO:0005102 [signaling receptor binding] GO:0005125 [cytokine activity] GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006874 [cellular calcium ion homeostasis] GO:0006885 [regulation of pH] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G protein-coupled receptor signaling pathway] GO:0007193 [adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007205 [protein kinase C-activating G protein-coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007507 [heart development] GO:0007585 [respiratory gaseous exchange by respiratory system] GO:0007589 [body fluid secretion] GO:0008217 [regulation of blood pressure] GO:0008284 [positive regulation of cell population proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010193 [response to ozone] GO:0010259 [multicellular organism aging] GO:0010460 [positive regulation of heart rate] GO:0010595 [positive regulation of endothelial cell migration] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010629 [negative regulation of gene expression] GO:0010827 [regulation of glucose transmembrane transport] GO:0014032 [neural crest cell development] GO:0014065 [phosphatidylinositol 3-kinase signaling] GO:0014823 [response to activity] GO:0014824 [artery smooth muscle contraction] GO:0014826 [vein smooth muscle contraction] GO:0019229 [regulation of vasoconstriction] GO:0019233 [sensory perception of pain] GO:0019722 [calcium-mediated signaling] GO:0030072 [peptide hormone secretion] GO:0030133 [transport vesicle] GO:0030185 [nitric oxide transport] GO:0030195 [negative regulation of blood coagulation] GO:0030335 [positive regulation of cell migration] GO:0031583 [phospholipase D-activating G protein-coupled receptor signaling pathway] GO:0031707 [endothelin A receptor binding] GO:0031708 [endothelin B receptor binding] GO:0032269 [negative regulation of cellular protein metabolic process] GO:0032308 [positive regulation of prostaglandin secretion] GO:0032496 [response to lipopolysaccharide] GO:0033093 [Weibel-Palade body] GO:0033574 [response to testosterone] GO:0034392 [negative regulation of smooth muscle cell apoptotic process] GO:0034696 [response to prostaglandin F] GO:0035094 [response to nicotine] GO:0035556 [intracellular signal transduction] GO:0035690 [cellular response to drug] GO:0035810 [positive regulation of urine volume] GO:0035815 [positive regulation of renal sodium excretion] GO:0035994 [response to muscle stretch] GO:0042045 [epithelial fluid transport] GO:0042310 [vasoconstriction] GO:0042313 [protein kinase C deactivation] GO:0042474 [middle ear morphogenesis] GO:0042482 [positive regulation of odontogenesis] GO:0042493 [response to drug] GO:0042554 [superoxide anion generation] GO:0043179 [rhythmic excitation] GO:0043200 [response to amino acid] GO:0043406 [positive regulation of MAP kinase activity] GO:0043507 [positive regulation of JUN kinase activity] GO:0044321 [response to leptin] GO:0045178 [basal part of cell] GO:0045321 [leukocyte activation] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045793 [positive regulation of cell size] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0045987 [positive regulation of smooth muscle contraction] GO:0046887 [positive regulation of hormone secretion] GO:0046888 [negative regulation of hormone secretion] GO:0048016 [inositol phosphate-mediated signaling] GO:0048237 [rough endoplasmic reticulum lumen] GO:0048514 [blood vessel morphogenesis] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051216 [cartilage development] GO:0051482 [positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway] GO:0051771 [negative regulation of nitric-oxide synthase biosynthetic process] GO:0051899 [membrane depolarization] GO:0051930 [regulation of sensory perception of pain] GO:0060137 [maternal process involved in parturition] GO:0060298 [positive regulation of sarcomere organization] GO:0060585 [positive regulation of prostaglandin-endoperoxide synthase activity] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070101 [positive regulation of chemokine-mediated signaling pathway] GO:0071277 [cellular response to calcium ion] GO:0071346 [cellular response to interferon-gamma] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071385 [cellular response to glucocorticoid stimulus] GO:0071389 [cellular response to mineralocorticoid stimulus] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071548 [response to dexamethasone] GO:0071559 [response to transforming growth factor beta] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0086100 [endothelin receptor signaling pathway] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1902074 [response to salt] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:2000273 [positive regulation of signaling receptor activity]