P49768 [Direct mapping]
Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit Presenilin-1 CTF12
A0A024R6A3 [Target identity:100%; Query identity:100%]
Presenilin

GO:0000045 [autophagosome assembly]
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000139 [Golgi membrane]
GO:0000186 [activation of MAPKK activity]
GO:0000776 [kinetochore]
GO:0001568 [blood vessel development]
GO:0001708 [cell fate specification]
GO:0001756 [somitogenesis]
GO:0001764 [neuron migration]
GO:0001921 [positive regulation of receptor recycling]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001947 [heart looping]
GO:0002038 [positive regulation of L-glutamate import across plasma membrane]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002265 [astrocyte activation involved in immune response]
GO:0002286 [T cell activation involved in immune response]
GO:0002573 [myeloid leukocyte differentiation]
GO:0003407 [neural retina development]
GO:0004175 [endopeptidase activity]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006486 [protein glycosylation]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0006816 [calcium ion transport]
GO:0006839 [mitochondrial transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007155 [cell adhesion]
GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0008013 [beta-catenin binding]
GO:0008021 [synaptic vesicle]
GO:0008233 [peptidase activity]
GO:0009791 [post-embryonic development]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010975 [regulation of neuron projection development]
GO:0015031 [protein transport]
GO:0015871 [choline transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016080 [synaptic vesicle targeting]
GO:0016235 [aggresome]
GO:0016324 [apical plasma membrane]
GO:0016485 [protein processing]
GO:0016787 [hydrolase activity]
GO:0021549 [cerebellum development]
GO:0021795 [cerebral cortex cell migration]
GO:0021870 [Cajal-Retzius cell differentiation]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0021987 [cerebral cortex development]
GO:0022008 [neurogenesis]
GO:0030018 [Z disc]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0030326 [embryonic limb morphogenesis]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030900 [forebrain development]
GO:0031293 [membrane protein intracellular domain proteolysis]
GO:0031410 [cytoplasmic vesicle]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032991 [protein-containing complex]
GO:0034205 [amyloid-beta formation]
GO:0035253 [ciliary rootlet]
GO:0035282 [segmentation]
GO:0035333 [Notch receptor processing, ligand-dependent]
GO:0035556 [intracellular signal transduction]
GO:0035577 [azurophil granule membrane]
GO:0040011 [locomotion]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042325 [regulation of phosphorylation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042383 [sarcolemma]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0043198 [dendritic shaft]
GO:0043227 [membrane-bounded organelle]
GO:0043312 [neutrophil degranulation]
GO:0043393 [regulation of protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043589 [skin morphogenesis]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045821 [positive regulation of glycolytic process]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048538 [thymus development]
GO:0048666 [neuron development]
GO:0048705 [skeletal system morphogenesis]
GO:0048854 [brain morphogenesis]
GO:0050435 [amyloid-beta metabolic process]
GO:0050673 [epithelial cell proliferation]
GO:0050771 [negative regulation of axonogenesis]
GO:0050808 [synapse organization]
GO:0050820 [positive regulation of coagulation]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0051208 [sequestering of calcium ion]
GO:0051402 [neuron apoptotic process]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]
GO:0051604 [protein maturation]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060075 [regulation of resting membrane potential]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0060999 [positive regulation of dendritic spine development]
GO:0070588 [calcium ion transmembrane transport]
GO:0070765 [gamma-secretase complex]
GO:0070851 [growth factor receptor binding]
GO:0090647 [modulation of age-related behavioral decline]
GO:0097060 [synaptic membrane]
GO:0098609 [cell-cell adhesion]
GO:0098712 [L-glutamate import across plasma membrane]
GO:0099056 [integral component of presynaptic membrane]
GO:1904646 [cellular response to amyloid-beta]
GO:1904797 [negative regulation of core promoter binding]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990535 [neuron projection maintenance]
GO:2000059 [negative regulation of ubiquitin-dependent protein catabolic process]
GO:2001234 [negative regulation of apoptotic signaling pathway]

P49768 [Direct mapping]
Presenilin-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit Presenilin-1 CTF12

GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000139 [Golgi membrane]
GO:0000776 [kinetochore]
GO:0002265 [astrocyte activation involved in immune response]
GO:0004175 [endopeptidase activity]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005640 [nuclear outer membrane]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005938 [cell cortex]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0006816 [calcium ion transport]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007155 [cell adhesion]
GO:0007219 [Notch signaling pathway]
GO:0007220 [Notch receptor processing]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0008013 [beta-catenin binding]
GO:0008233 [peptidase activity]
GO:0009986 [cell surface]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010975 [regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016235 [aggresome]
GO:0016324 [apical plasma membrane]
GO:0016485 [protein processing]
GO:0016787 [hydrolase activity]
GO:0030018 [Z disc]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031293 [membrane protein intracellular domain proteolysis]
GO:0031594 [neuromuscular junction]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0032092 [positive regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032991 [protein-containing complex]
GO:0034205 [amyloid-beta formation]
GO:0035253 [ciliary rootlet]
GO:0035333 [Notch receptor processing, ligand-dependent]
GO:0035556 [intracellular signal transduction]
GO:0035577 [azurophil granule membrane]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042325 [regulation of phosphorylation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0042987 [amyloid precursor protein catabolic process]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0043198 [dendritic shaft]
GO:0043312 [neutrophil degranulation]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045296 [cadherin binding]
GO:0045821 [positive regulation of glycolytic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048143 [astrocyte activation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050435 [amyloid-beta metabolic process]
GO:0050808 [synapse organization]
GO:0051117 [ATPase binding]
GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0060999 [positive regulation of dendritic spine development]
GO:0070588 [calcium ion transmembrane transport]
GO:0070765 [gamma-secretase complex]
GO:0070851 [growth factor receptor binding]
GO:0090647 [modulation of age-related behavioral decline]
GO:0098609 [cell-cell adhesion]
GO:1904646 [cellular response to amyloid-beta]
GO:1904797 [negative regulation of core promoter binding]
GO:1905908 [positive regulation of amyloid fibril formation]
GO:1990535 [neuron projection maintenance]

E7ES96 [Direct mapping]
Presenilin

GO:0000139 [Golgi membrane]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006508 [proteolysis]
GO:0007219 [Notch signaling pathway]
GO:0008233 [peptidase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0016787 [hydrolase activity]

G3V499 [Direct mapping]
Presenilin-1 CTF12

GO:0004190 [aspartic-type endopeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0030054 [cell junction]
GO:0031901 [early endosome membrane]
GO:0035556 [intracellular signal transduction]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042987 [amyloid precursor protein catabolic process]

G3V2G7 [Direct mapping]
Presenilin-1 CTF12

GO:0004190 [aspartic-type endopeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0030054 [cell junction]
GO:0031901 [early endosome membrane]
GO:0035556 [intracellular signal transduction]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042987 [amyloid precursor protein catabolic process]

G3V5B1 [Direct mapping]
Presenilin-1

GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006508 [proteolysis]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0035556 [intracellular signal transduction]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042987 [amyloid precursor protein catabolic process]

G3V449 [Direct mapping]
Presenilin-1

GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006508 [proteolysis]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0035556 [intracellular signal transduction]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042987 [amyloid precursor protein catabolic process]

G3V3P0 [Direct mapping]
Presenilin-1

GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006508 [proteolysis]
GO:0016020 [membrane]
GO:0030054 [cell junction]
GO:0035556 [intracellular signal transduction]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042987 [amyloid precursor protein catabolic process]

G3V3Z0 [Direct mapping]
Presenilin-1 CTF12

GO:0004190 [aspartic-type endopeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0030054 [cell junction]
GO:0031901 [early endosome membrane]
GO:0035556 [intracellular signal transduction]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042987 [amyloid precursor protein catabolic process]

H0YM52 [Direct mapping]
Presenilin-1 CTF12

GO:0004190 [aspartic-type endopeptidase activity]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016485 [protein processing]
GO:0030054 [cell junction]
GO:0031901 [early endosome membrane]
GO:0035556 [intracellular signal transduction]
GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving]
GO:0042987 [amyloid precursor protein catabolic process]