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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q32.31
Chromosome location (bp)
102080742 - 102139699
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HSP90AA1-201
HSP90AA1-202
HSP90AA1-203
HSP90AA1-209
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P07900 [Direct mapping] Heat shock protein HSP 90-alpha K9JA46 [Target identity:100%; Query identity:100%] Epididymis luminal secretory protein 52; Epididymis secretory sperm binding protein Li 65p; Heat shock protein 90kDa alpha (Cytosolic), class A member 1, isoform CRA_a
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0002218 [activation of innate immune response] GO:0002230 [positive regulation of defense response to virus by host] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006839 [mitochondrial transport] GO:0006898 [receptor-mediated endocytosis] GO:0006986 [response to unfolded protein] GO:0007004 [telomere maintenance via telomerase] GO:0009408 [response to heat] GO:0009409 [response to cold] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016887 [ATPase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0021955 [central nervous system neuron axonogenesis] GO:0023026 [MHC class II protein complex binding] GO:0030010 [establishment of cell polarity] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030911 [TPR domain binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0032273 [positive regulation of protein polymerization] GO:0032728 [positive regulation of interferon-beta production] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034605 [cellular response to heat] GO:0034774 [secretory granule lumen] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042026 [protein refolding] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043025 [neuronal cell body] GO:0043202 [lysosomal lumen] GO:0043209 [myelin sheath] GO:0043254 [regulation of protein-containing complex assembly] GO:0043312 [neutrophil degranulation] GO:0043335 [protein unfolding] GO:0044294 [dendritic growth cone] GO:0044295 [axonal growth cone] GO:0045040 [protein insertion into mitochondrial outer membrane] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0046677 [response to antibiotic] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050821 [protein stabilization] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051020 [GTPase binding] GO:0051082 [unfolded protein binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051973 [positive regulation of telomerase activity] GO:0061684 [chaperone-mediated autophagy] GO:0070062 [extracellular exosome] GO:0070182 [DNA polymerase binding] GO:0071682 [endocytic vesicle lumen] GO:0097110 [scaffold protein binding] GO:0097711 [ciliary basal body-plasma membrane docking] GO:0097718 [disordered domain specific binding] GO:0098586 [cellular response to virus] GO:1900034 [regulation of cellular response to heat] GO:1902949 [positive regulation of tau-protein kinase activity] GO:1903364 [positive regulation of cellular protein catabolic process] GO:1903827 [regulation of cellular protein localization] GO:1904813 [ficolin-1-rich granule lumen] GO:1905323 [telomerase holoenzyme complex assembly] GO:1990782 [protein tyrosine kinase binding]
P07900 [Direct mapping] Heat shock protein HSP 90-alpha
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000166 [nucleotide binding] GO:0001934 [positive regulation of protein phosphorylation] GO:0002218 [activation of innate immune response] GO:0002230 [positive regulation of defense response to virus by host] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006839 [mitochondrial transport] GO:0006898 [receptor-mediated endocytosis] GO:0006986 [response to unfolded protein] GO:0007004 [telomere maintenance via telomerase] GO:0009408 [response to heat] GO:0009409 [response to cold] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016887 [ATPase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0021955 [central nervous system neuron axonogenesis] GO:0023026 [MHC class II protein complex binding] GO:0030010 [establishment of cell polarity] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030911 [TPR domain binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0032273 [positive regulation of protein polymerization] GO:0032728 [positive regulation of interferon-beta production] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034605 [cellular response to heat] GO:0034774 [secretory granule lumen] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0038128 [ERBB2 signaling pathway] GO:0042026 [protein refolding] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0042981 [regulation of apoptotic process] GO:0043025 [neuronal cell body] GO:0043202 [lysosomal lumen] GO:0043209 [myelin sheath] GO:0043254 [regulation of protein-containing complex assembly] GO:0043312 [neutrophil degranulation] GO:0043335 [protein unfolding] GO:0044183 [protein folding chaperone] GO:0044294 [dendritic growth cone] GO:0044295 [axonal growth cone] GO:0045040 [protein insertion into mitochondrial outer membrane] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0046677 [response to antibiotic] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050821 [protein stabilization] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051020 [GTPase binding] GO:0051082 [unfolded protein binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051973 [positive regulation of telomerase activity] GO:0061684 [chaperone-mediated autophagy] GO:0070062 [extracellular exosome] GO:0070182 [DNA polymerase binding] GO:0071682 [endocytic vesicle lumen] GO:0097110 [scaffold protein binding] GO:0097711 [ciliary basal body-plasma membrane docking] GO:0097718 [disordered domain specific binding] GO:0098586 [cellular response to virus] GO:1900034 [regulation of cellular response to heat] GO:1902949 [positive regulation of tau-protein kinase activity] GO:1903364 [positive regulation of cellular protein catabolic process] GO:1903827 [regulation of cellular protein localization] GO:1904813 [ficolin-1-rich granule lumen] GO:1905323 [telomerase holoenzyme complex assembly] GO:1990782 [protein tyrosine kinase binding]
G3V2J8 [Direct mapping] Heat shock protein HSP 90-alpha
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
A0A0U1RR69 [Direct mapping] Heat shock protein HSP 90-alpha
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)