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BAX
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  • BAX
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

BAX
Synonyms BCL2L4
Gene descriptioni

Full gene name according to HGNC.

BCL2 associated X, apoptosis regulator
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Human disease related genes
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 19
Cytoband q13.33
Chromosome location (bp) 48954815 - 48961798
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

7
Ensembl ENSG00000087088 (version 103.38)
Entrez gene 581
HGNC HGNC:959
UniProt Q07812 (UniProt - Evidence at protein level)
neXtProt NX_Q07812
Antibodypedia BAX antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 1      # Population variants: 115

Experimental

Description: SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX (NMR)

# Chains: 1      # Clinical variants: 1      # Population variants: 115

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BAX-201
BAX-202
BAX-203
BAX-205
BAX-206
BAX-209
BAX-213


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
BAX-201
ENSP00000293288
ENST00000293288
Q07812 [Direct mapping]
Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0001764 [neuron migration]
GO:0001776 [leukocyte homeostasis]
GO:0001777 [T cell homeostatic proliferation]
GO:0001782 [B cell homeostasis]
GO:0001783 [B cell apoptotic process]
GO:0001822 [kidney development]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001844 [protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:0001974 [blood vessel remodeling]
GO:0002262 [myeloid cell homeostasis]
GO:0002352 [B cell negative selection]
GO:0002358 [B cell homeostatic proliferation]
GO:0002904 [positive regulation of B cell apoptotic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006687 [glycosphingolipid metabolic process]
GO:0006808 [regulation of nitrogen utilization]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007281 [germ cell development]
GO:0007283 [spermatogenesis]
GO:0007399 [nervous system development]
GO:0007548 [sex differentiation]
GO:0008053 [mitochondrial fusion]
GO:0008283 [cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008289 [lipid binding]
GO:0008584 [male gonad development]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009566 [fertilization]
GO:0009611 [response to wounding]
GO:0009636 [response to toxic substance]
GO:0009651 [response to salt stress]
GO:0009791 [post-embryonic development]
GO:0010212 [response to ionizing radiation]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010332 [response to gamma radiation]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0021854 [hypothalamus development]
GO:0021987 [cerebral cortex development]
GO:0030544 [Hsp70 protein binding]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0031966 [mitochondrial membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033599 [regulation of mammary gland epithelial cell proliferation]
GO:0034620 [cellular response to unfolded protein]
GO:0034644 [cellular response to UV]
GO:0035108 [limb morphogenesis]
GO:0035234 [ectopic germ cell programmed cell death]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0045136 [development of secondary sexual characteristics]
GO:0046666 [retinal cell programmed cell death]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0048087 [positive regulation of developmental pigmentation]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048515 [spermatid differentiation]
GO:0048597 [post-embryonic camera-type eye morphogenesis]
GO:0048678 [response to axon injury]
GO:0048872 [homeostasis of number of cells]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0051087 [chaperone binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051402 [neuron apoptotic process]
GO:0051434 [BH3 domain binding]
GO:0051726 [regulation of cell cycle]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0060011 [Sertoli cell proliferation]
GO:0060041 [retina development in camera-type eye]
GO:0060058 [positive regulation of apoptotic process involved in mammary gland involution]
GO:0060068 [vagina development]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0070242 [thymocyte apoptotic process]
GO:0070584 [mitochondrion morphogenesis]
GO:0071310 [cellular response to organic substance]
GO:0071944 [cell periphery]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902110 [positive regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902262 [apoptotic process involved in blood vessel morphogenesis]
GO:1902263 [apoptotic process involved in embryonic digit morphogenesis]
GO:1902445 [regulation of mitochondrial membrane permeability involved in programmed necrotic cell death]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
218 aa
24.2 kDa
No 0
BAX-202
ENSP00000263262
ENST00000345358
Q07812 [Direct mapping]
Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001783 [B cell apoptotic process]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001844 [protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008053 [mitochondrial fusion]
GO:0008289 [lipid binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009636 [response to toxic substance]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0034620 [cellular response to unfolded protein]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
192 aa
21.2 kDa
No 0
BAX-203
ENSP00000346461
ENST00000354470
Q07812 [Direct mapping]
Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001783 [B cell apoptotic process]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001844 [protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008053 [mitochondrial fusion]
GO:0008289 [lipid binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009636 [response to toxic substance]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0034620 [cellular response to unfolded protein]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
143 aa
15.8 kDa
No 0
BAX-205
ENSP00000375744
ENST00000391871
K4JQN1 [Direct mapping]
Apoptosis regulator BAX; BCL2-associated X protein transcript variant delta2
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
Show all
175 aa
19.3 kDa
No 0
BAX-206
ENSP00000389971
ENST00000415969
Q07812 [Direct mapping]
Apoptosis regulator BAX
Show all
Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001783 [B cell apoptotic process]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001844 [protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005757 [mitochondrial permeability transition pore complex]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0008053 [mitochondrial fusion]
GO:0008289 [lipid binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0008635 [activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c]
GO:0008637 [apoptotic mitochondrial changes]
GO:0009636 [response to toxic substance]
GO:0010248 [establishment or maintenance of transmembrane electrochemical gradient]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0031334 [positive regulation of protein-containing complex assembly]
GO:0032091 [negative regulation of protein binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0032976 [release of matrix enzymes from mitochondria]
GO:0034620 [cellular response to unfolded protein]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0046930 [pore complex]
GO:0046982 [protein heterodimerization activity]
GO:0051434 [BH3 domain binding]
GO:0051881 [regulation of mitochondrial membrane potential]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097136 [Bcl-2 family protein complex]
GO:0097144 [BAX complex]
GO:0097145 [BAK complex]
GO:0097190 [apoptotic signaling pathway]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0098586 [cellular response to virus]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1902512 [positive regulation of apoptotic DNA fragmentation]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:1990117 [B cell receptor apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
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179 aa
19.7 kDa
No 0
BAX-209
ENSP00000426184
ENST00000506183
H0YA56 [Direct mapping]
Apoptosis regulator BAX
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
Show all
126 aa
14.1 kDa
No 0
BAX-213
ENSP00000441413
ENST00000539787
I6LPK7 [Direct mapping]
Apoptosis regulator BAX; BCL2-associated X protein theta
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006915 [apoptotic process]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
Show all
140 aa
15.9 kDa
No 0

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