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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Candidate cardiovascular disease genes CD markers FDA approved drug targets Human disease related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.2
Chromosome location (bp)
10271093 - 10286615
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ICAM1-201
ICAM1-202
ICAM1-204
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development] GO:0001618 [virus receptor activity] GO:0001666 [response to hypoxia] GO:0001772 [immunological synapse] GO:0001910 [regulation of leukocyte mediated cytotoxicity] GO:0001975 [response to amphetamine] GO:0002291 [T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell] GO:0002438 [acute inflammatory response to antigenic stimulus] GO:0002457 [T cell antigen processing and presentation] GO:0002693 [positive regulation of cellular extravasation] GO:0004888 [transmembrane signaling receptor activity] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007159 [leukocyte cell-cell adhesion] GO:0007569 [cell aging] GO:0007605 [sensory perception of sound] GO:0008360 [regulation of cell shape] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010212 [response to ionizing radiation] GO:0010477 [response to sulfur dioxide] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0022614 [membrane to membrane docking] GO:0030198 [extracellular matrix organization] GO:0030838 [positive regulation of actin filament polymerization] GO:0031669 [cellular response to nutrient levels] GO:0032496 [response to lipopolysaccharide] GO:0032868 [response to insulin] GO:0033627 [cell adhesion mediated by integrin] GO:0034698 [response to gonadotropin] GO:0038023 [signaling receptor activity] GO:0042493 [response to drug] GO:0043200 [response to amino acid] GO:0043547 [positive regulation of GTPase activity] GO:0044406 [adhesion of symbiont to host] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045471 [response to ethanol] GO:0045907 [positive regulation of vasoconstriction] GO:0046688 [response to copper ion] GO:0046718 [viral entry into host cell] GO:0046813 [receptor-mediated virion attachment to host cell] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0050900 [leukocyte migration] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051926 [negative regulation of calcium ion transport] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0061028 [establishment of endothelial barrier] GO:0062023 [collagen-containing extracellular matrix] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071222 [cellular response to lipopolysaccharide] GO:0071310 [cellular response to organic substance] GO:0071312 [cellular response to alkaloid] GO:0071333 [cellular response to glucose stimulus] GO:0071346 [cellular response to interferon-gamma] GO:0071347 [cellular response to interleukin-1] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:0071456 [cellular response to hypoxia] GO:0071549 [cellular response to dexamethasone stimulus] GO:0072683 [T cell extravasation] GO:0090557 [establishment of endothelial intestinal barrier] GO:0097368 [establishment of Sertoli cell barrier] GO:0098609 [cell-cell adhesion] GO:1900027 [regulation of ruffle assembly] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1904646 [cellular response to amyloid-beta] GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell] GO:1990830 [cellular response to leukemia inhibitory factor] GO:2000352 [negative regulation of endothelial cell apoptotic process]
The Human Protein Atlas project is funded
