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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q14.3
Chromosome location (bp)
66189195 - 66254622
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
IRAK3-201
IRAK3-202
IRAK3-203
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases SignalP predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0001960 [negative regulation of cytokine-mediated signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0009615 [response to virus] GO:0010933 [positive regulation of macrophage tolerance induction] GO:0010936 [negative regulation of macrophage cytokine production] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032494 [response to peptidoglycan] GO:0032496 [response to lipopolysaccharide] GO:0032695 [negative regulation of interleukin-12 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034122 [negative regulation of toll-like receptor signaling pathway] GO:0035556 [intracellular signal transduction] GO:0042177 [negative regulation of protein catabolic process] GO:0042803 [protein homodimerization activity] GO:0043242 [negative regulation of protein-containing complex disassembly] GO:0043244 [regulation of protein-containing complex disassembly] GO:0043330 [response to exogenous dsRNA] GO:0043407 [negative regulation of MAP kinase activity] GO:0045824 [negative regulation of innate immune response] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070498 [interleukin-1-mediated signaling pathway] GO:0070555 [response to interleukin-1] GO:0106310 [] GO:0106311 []
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases SignalP predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0000287 [magnesium ion binding] GO:0001960 [negative regulation of cytokine-mediated signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0009615 [response to virus] GO:0010933 [positive regulation of macrophage tolerance induction] GO:0010936 [negative regulation of macrophage cytokine production] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016740 [transferase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032494 [response to peptidoglycan] GO:0032496 [response to lipopolysaccharide] GO:0032695 [negative regulation of interleukin-12 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034122 [negative regulation of toll-like receptor signaling pathway] GO:0035556 [intracellular signal transduction] GO:0042177 [negative regulation of protein catabolic process] GO:0042803 [protein homodimerization activity] GO:0043242 [negative regulation of protein-containing complex disassembly] GO:0043244 [regulation of protein-containing complex disassembly] GO:0043330 [response to exogenous dsRNA] GO:0043407 [negative regulation of MAP kinase activity] GO:0045824 [negative regulation of innate immune response] GO:0046982 [protein heterodimerization activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0070498 [interleukin-1-mediated signaling pathway] GO:0070555 [response to interleukin-1] GO:0106310 [] GO:0106311 []
The Human Protein Atlas project is funded
