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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
Chromosome location (bp)
151656691 - 152129619
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Nuclear receptors THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001093 [TFIIB-class transcription factor binding] GO:0001223 [transcription coactivator binding] GO:0001226 [RNA polymerase II transcription corepressor binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008289 [lipid binding] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0017025 [TBP-class protein binding] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030111 [regulation of Wnt signaling pathway] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0032355 [response to estradiol] GO:0032991 [protein-containing complex] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0035327 [transcriptionally active chromatin] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of DNA-binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051117 [ATPase binding] GO:0051897 [positive regulation of protein kinase B signaling] GO:0071168 [protein localization to chromatin] GO:0071392 [cellular response to estradiol stimulus] GO:0097550 [transcription preinitiation complex] GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA] GO:1990837 [sequence-specific double-stranded DNA binding]
Nuclear receptors THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001093 [TFIIB-class transcription factor binding] GO:0001223 [transcription coactivator binding] GO:0001226 [RNA polymerase II transcription corepressor binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008289 [lipid binding] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0017025 [TBP-class protein binding] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030111 [regulation of Wnt signaling pathway] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0032355 [response to estradiol] GO:0032991 [protein-containing complex] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0035327 [transcriptionally active chromatin] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of DNA-binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051117 [ATPase binding] GO:0051897 [positive regulation of protein kinase B signaling] GO:0071168 [protein localization to chromatin] GO:0071392 [cellular response to estradiol stimulus] GO:0097550 [transcription preinitiation complex] GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA] GO:1990837 [sequence-specific double-stranded DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases
SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases
Nuclear receptors THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001093 [TFIIB-class transcription factor binding] GO:0001223 [transcription coactivator binding] GO:0001226 [RNA polymerase II transcription corepressor binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001547 [antral ovarian follicle growth] GO:0002064 [epithelial cell development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008209 [androgen metabolic process] GO:0008270 [zinc ion binding] GO:0008289 [lipid binding] GO:0008584 [male gonad development] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0017025 [TBP-class protein binding] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030111 [regulation of Wnt signaling pathway] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0032355 [response to estradiol] GO:0032991 [protein-containing complex] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0034121 [regulation of toll-like receptor signaling pathway] GO:0035327 [transcriptionally active chromatin] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of DNA-binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048863 [stem cell differentiation] GO:0050727 [regulation of inflammatory response] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051117 [ATPase binding] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060065 [uterus development] GO:0060068 [vagina development] GO:0060523 [prostate epithelial cord elongation] GO:0060527 [prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis] GO:0060687 [regulation of branching involved in prostate gland morphogenesis] GO:0060745 [mammary gland branching involved in pregnancy] GO:0060749 [mammary gland alveolus development] GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation] GO:0071168 [protein localization to chromatin] GO:0071391 [cellular response to estrogen stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0097550 [transcription preinitiation complex] GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA] GO:1990837 [sequence-specific double-stranded DNA binding]
Nuclear receptors THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001093 [TFIIB-class transcription factor binding] GO:0001223 [transcription coactivator binding] GO:0001226 [RNA polymerase II transcription corepressor binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [DNA-binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007200 [phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008289 [lipid binding] GO:0010629 [negative regulation of gene expression] GO:0010863 [positive regulation of phospholipase C activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016579 [protein deubiquitination] GO:0017025 [TBP-class protein binding] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030111 [regulation of Wnt signaling pathway] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030284 [estrogen receptor activity] GO:0030331 [estrogen receptor binding] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0032355 [response to estradiol] GO:0032991 [protein-containing complex] GO:0033146 [regulation of intracellular estrogen receptor signaling pathway] GO:0034056 [estrogen response element binding] GO:0035327 [transcriptionally active chromatin] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043433 [negative regulation of DNA-binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0043627 [response to estrogen] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045899 [positive regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051117 [ATPase binding] GO:0051897 [positive regulation of protein kinase B signaling] GO:0071168 [protein localization to chromatin] GO:0071392 [cellular response to estradiol stimulus] GO:0097550 [transcription preinitiation complex] GO:1903799 [negative regulation of production of miRNAs involved in gene silencing by miRNA] GO:1990837 [sequence-specific double-stranded DNA binding]
Q9UE35 [Direct mapping] Estrogen receptor; Estrogen receptor protein
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Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases
Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the breast and female genital organs Endocrine and metabolic diseases Gonadal diseases
The Human Protein Atlas project is funded
