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TGFB2
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  • TGFB2
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

TGFB2
Synonyms
Gene descriptioni

Full gene name according to HGNC.

Transforming growth factor beta 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Human disease related genes
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 1
Cytoband q41
Chromosome location (bp) 218345336 - 218444619
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000092969 (version 103.38)
Entrez gene 7042
HGNC HGNC:11768
UniProt P61812 (UniProt - Evidence at protein level)
neXtProt NX_P61812
Antibodypedia TGFB2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 6      # Population variants: 164

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
TGFB2-201
TGFB2-202


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
TGFB2-201
ENSP00000355896
ENST00000366929
P61812 [Direct mapping]
Transforming growth factor beta-2 proprotein Latency-associated peptide Transforming growth factor beta-2
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001501 [skeletal system development]
GO:0001540 [amyloid-beta binding]
GO:0001654 [eye development]
GO:0001666 [response to hypoxia]
GO:0001822 [kidney development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0002576 [platelet degranulation]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0003179 [heart valve morphogenesis]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003274 [endocardial cushion fusion]
GO:0003289 [atrial septum primum morphogenesis]
GO:0003407 [neural retina development]
GO:0005102 [signaling receptor binding]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006468 [protein phosphorylation]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007435 [salivary gland morphogenesis]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008219 [cell death]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008347 [glial cell migration]
GO:0008584 [male gonad development]
GO:0009611 [response to wounding]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0010002 [cardioblast differentiation]
GO:0010629 [negative regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010693 [negative regulation of alkaline phosphatase activity]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0010936 [negative regulation of macrophage cytokine production]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0016525 [negative regulation of angiogenesis]
GO:0030097 [hemopoiesis]
GO:0030199 [collagen fibril organization]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030424 [axon]
GO:0030509 [BMP signaling pathway]
GO:0030593 [neutrophil chemotaxis]
GO:0031069 [hair follicle morphogenesis]
GO:0031093 [platelet alpha granule lumen]
GO:0032147 [activation of protein kinase activity]
GO:0032570 [response to progesterone]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0034714 [type III transforming growth factor beta receptor binding]
GO:0035910 [ascending aorta morphogenesis]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell population proliferation]
GO:0042416 [dopamine biosynthetic process]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0042704 [uterine wall breakdown]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045216 [cell-cell junction organization]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045778 [positive regulation of ossification]
GO:0045787 [positive regulation of cell cycle]
GO:0045823 [positive regulation of heart contraction]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048103 [somatic stem cell division]
GO:0048566 [embryonic digestive tract development]
GO:0048666 [neuron development]
GO:0048699 [generation of neurons]
GO:0048839 [inner ear development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050778 [positive regulation of immune response]
GO:0051781 [positive regulation of cell division]
GO:0051794 [regulation of timing of catagen]
GO:0051795 [positive regulation of timing of catagen]
GO:0051891 [positive regulation of cardioblast differentiation]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060065 [uterus development]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0060412 [ventricular septum morphogenesis]
GO:0060413 [atrial septum morphogenesis]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0062009 [secondary palate development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1902256 [regulation of apoptotic process involved in outflow tract morphogenesis]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903701 [substantia propria of cornea development]
GO:1904888 [cranial skeletal system development]
GO:1905006 [negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:1905007 [positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
Show all
442 aa
50.6 kDa
Yes 0
TGFB2-202
ENSP00000355897
ENST00000366930
P61812 [Direct mapping]
Transforming growth factor beta-2 proprotein Latency-associated peptide Transforming growth factor beta-2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the circulatory system
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000902 [cell morphogenesis]
GO:0001501 [skeletal system development]
GO:0001540 [amyloid-beta binding]
GO:0001654 [eye development]
GO:0001666 [response to hypoxia]
GO:0001822 [kidney development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0002576 [platelet degranulation]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003149 [membranous septum morphogenesis]
GO:0003179 [heart valve morphogenesis]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003274 [endocardial cushion fusion]
GO:0003289 [atrial septum primum morphogenesis]
GO:0003407 [neural retina development]
GO:0005102 [signaling receptor binding]
GO:0005114 [type II transforming growth factor beta receptor binding]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006468 [protein phosphorylation]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007435 [salivary gland morphogenesis]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008219 [cell death]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008347 [glial cell migration]
GO:0008584 [male gonad development]
GO:0009611 [response to wounding]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0010002 [cardioblast differentiation]
GO:0010629 [negative regulation of gene expression]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010693 [negative regulation of alkaline phosphatase activity]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0010936 [negative regulation of macrophage cytokine production]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0016525 [negative regulation of angiogenesis]
GO:0030097 [hemopoiesis]
GO:0030199 [collagen fibril organization]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0030326 [embryonic limb morphogenesis]
GO:0030424 [axon]
GO:0030509 [BMP signaling pathway]
GO:0030593 [neutrophil chemotaxis]
GO:0031069 [hair follicle morphogenesis]
GO:0031093 [platelet alpha granule lumen]
GO:0032147 [activation of protein kinase activity]
GO:0032570 [response to progesterone]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0032909 [regulation of transforming growth factor beta2 production]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0034714 [type III transforming growth factor beta receptor binding]
GO:0035910 [ascending aorta morphogenesis]
GO:0042060 [wound healing]
GO:0042127 [regulation of cell population proliferation]
GO:0042416 [dopamine biosynthetic process]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0042704 [uterine wall breakdown]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045216 [cell-cell junction organization]
GO:0045726 [positive regulation of integrin biosynthetic process]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045778 [positive regulation of ossification]
GO:0045787 [positive regulation of cell cycle]
GO:0045823 [positive regulation of heart contraction]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048103 [somatic stem cell division]
GO:0048566 [embryonic digestive tract development]
GO:0048666 [neuron development]
GO:0048699 [generation of neurons]
GO:0048839 [inner ear development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050714 [positive regulation of protein secretion]
GO:0050778 [positive regulation of immune response]
GO:0051781 [positive regulation of cell division]
GO:0051794 [regulation of timing of catagen]
GO:0051795 [positive regulation of timing of catagen]
GO:0051891 [positive regulation of cardioblast differentiation]
GO:0060038 [cardiac muscle cell proliferation]
GO:0060065 [uterus development]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0060412 [ventricular septum morphogenesis]
GO:0060413 [atrial septum morphogenesis]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0062009 [secondary palate development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1902256 [regulation of apoptotic process involved in outflow tract morphogenesis]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1903701 [substantia propria of cornea development]
GO:1904888 [cranial skeletal system development]
GO:1905006 [negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:1905007 [positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation]
Show all
414 aa
47.7 kDa
Yes 0

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