We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.1
Chromosome location (bp)
44246166 - 44253888
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HSP90AB1-201
HSP90AB1-202
HSP90AB1-203
HSP90AB1-204
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P08238 [Direct mapping] Heat shock protein HSP 90-beta A0A024RD80 [Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006805 [xenobiotic metabolic process] GO:0006986 [response to unfolded protein] GO:0007004 [telomere maintenance via telomerase] GO:0008180 [COP9 signalosome] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019062 [virion attachment to host cell] GO:0019900 [kinase binding] GO:0021955 [central nervous system neuron axonogenesis] GO:0023026 [MHC class II protein complex binding] GO:0030010 [establishment of cell polarity] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030911 [TPR domain binding] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032516 [positive regulation of phosphoprotein phosphatase activity] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034605 [cellular response to heat] GO:0034751 [aryl hydrocarbon receptor complex] GO:0034774 [secretory granule lumen] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042277 [peptide binding] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043008 [ATP-dependent protein binding] GO:0043025 [neuronal cell body] GO:0043312 [neutrophil degranulation] GO:0044294 [dendritic growth cone] GO:0044295 [axonal growth cone] GO:0045296 [cadherin binding] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045597 [positive regulation of cell differentiation] GO:0046983 [protein dimerization activity] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050821 [protein stabilization] GO:0051082 [unfolded protein binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051248 [negative regulation of protein metabolic process] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051973 [positive regulation of telomerase activity] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0070182 [DNA polymerase binding] GO:0071157 [negative regulation of cell cycle arrest] GO:0097435 [supramolecular fiber organization] GO:0097718 [disordered domain specific binding] GO:1900034 [regulation of cellular response to heat] GO:1901389 [negative regulation of transforming growth factor beta activation] GO:1901799 [negative regulation of proteasomal protein catabolic process] GO:1902949 [positive regulation of tau-protein kinase activity] GO:1903827 [regulation of cellular protein localization] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904813 [ficolin-1-rich granule lumen] GO:1905323 [telomerase holoenzyme complex assembly] GO:1990226 [histone methyltransferase binding] GO:1990565 [HSP90-CDC37 chaperone complex] GO:2000010 [positive regulation of protein localization to cell surface]
P08238 [Direct mapping] Heat shock protein HSP 90-beta A0A024RD80 [Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001890 [placenta development] GO:0002134 [UTP binding] GO:0002135 [CTP binding] GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005525 [GTP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005765 [lysosomal membrane] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006805 [xenobiotic metabolic process] GO:0006986 [response to unfolded protein] GO:0007004 [telomere maintenance via telomerase] GO:0008144 [drug binding] GO:0008180 [COP9 signalosome] GO:0009651 [response to salt stress] GO:0009986 [cell surface] GO:0010033 [response to organic substance] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0017098 [sulfonylurea receptor binding] GO:0019062 [virion attachment to host cell] GO:0019887 [protein kinase regulator activity] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0021955 [central nervous system neuron axonogenesis] GO:0023026 [MHC class II protein complex binding] GO:0030010 [establishment of cell polarity] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030911 [TPR domain binding] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031526 [brush border membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0032092 [positive regulation of protein binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032516 [positive regulation of phosphoprotein phosphatase activity] GO:0032564 [dATP binding] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034605 [cellular response to heat] GO:0034751 [aryl hydrocarbon receptor complex] GO:0034774 [secretory granule lumen] GO:0035690 [cellular response to drug] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042220 [response to cocaine] GO:0042277 [peptide binding] GO:0042307 [positive regulation of protein import into nucleus] GO:0042470 [melanosome] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043008 [ATP-dependent protein binding] GO:0043025 [neuronal cell body] GO:0043066 [negative regulation of apoptotic process] GO:0043312 [neutrophil degranulation] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044183 [protein folding chaperone] GO:0044294 [dendritic growth cone] GO:0044295 [axonal growth cone] GO:0044325 [ion channel binding] GO:0045296 [cadherin binding] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045597 [positive regulation of cell differentiation] GO:0045793 [positive regulation of cell size] GO:0046983 [protein dimerization activity] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050821 [protein stabilization] GO:0051082 [unfolded protein binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051248 [negative regulation of protein metabolic process] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051973 [positive regulation of telomerase activity] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0070182 [DNA polymerase binding] GO:0071157 [negative regulation of cell cycle arrest] GO:0071353 [cellular response to interleukin-4] GO:0071407 [cellular response to organic cyclic compound] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0097435 [supramolecular fiber organization] GO:0097718 [disordered domain specific binding] GO:1900034 [regulation of cellular response to heat] GO:1901389 [negative regulation of transforming growth factor beta activation] GO:1901799 [negative regulation of proteasomal protein catabolic process] GO:1902949 [positive regulation of tau-protein kinase activity] GO:1903660 [negative regulation of complement-dependent cytotoxicity] GO:1903827 [regulation of cellular protein localization] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904813 [ficolin-1-rich granule lumen] GO:1905323 [telomerase holoenzyme complex assembly] GO:1990226 [histone methyltransferase binding] GO:1990565 [HSP90-CDC37 chaperone complex] GO:1990913 [sperm head plasma membrane] GO:1990917 [ooplasm] GO:2000010 [positive regulation of protein localization to cell surface]
P08238 [Direct mapping] Heat shock protein HSP 90-beta A0A024RD80 [Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006805 [xenobiotic metabolic process] GO:0006986 [response to unfolded protein] GO:0007004 [telomere maintenance via telomerase] GO:0008180 [COP9 signalosome] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019062 [virion attachment to host cell] GO:0019900 [kinase binding] GO:0021955 [central nervous system neuron axonogenesis] GO:0023026 [MHC class II protein complex binding] GO:0030010 [establishment of cell polarity] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030911 [TPR domain binding] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032516 [positive regulation of phosphoprotein phosphatase activity] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034605 [cellular response to heat] GO:0034751 [aryl hydrocarbon receptor complex] GO:0034774 [secretory granule lumen] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042277 [peptide binding] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043008 [ATP-dependent protein binding] GO:0043025 [neuronal cell body] GO:0043312 [neutrophil degranulation] GO:0044294 [dendritic growth cone] GO:0044295 [axonal growth cone] GO:0045296 [cadherin binding] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045597 [positive regulation of cell differentiation] GO:0046983 [protein dimerization activity] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050821 [protein stabilization] GO:0051082 [unfolded protein binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051248 [negative regulation of protein metabolic process] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051973 [positive regulation of telomerase activity] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0070182 [DNA polymerase binding] GO:0071157 [negative regulation of cell cycle arrest] GO:0097435 [supramolecular fiber organization] GO:0097718 [disordered domain specific binding] GO:1900034 [regulation of cellular response to heat] GO:1901389 [negative regulation of transforming growth factor beta activation] GO:1901799 [negative regulation of proteasomal protein catabolic process] GO:1902949 [positive regulation of tau-protein kinase activity] GO:1903827 [regulation of cellular protein localization] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904813 [ficolin-1-rich granule lumen] GO:1905323 [telomerase holoenzyme complex assembly] GO:1990226 [histone methyltransferase binding] GO:1990565 [HSP90-CDC37 chaperone complex] GO:2000010 [positive regulation of protein localization to cell surface]
P08238 [Direct mapping] Heat shock protein HSP 90-beta A0A024RD80 [Target identity:100%; Query identity:100%] Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006457 [protein folding] GO:0006805 [xenobiotic metabolic process] GO:0006986 [response to unfolded protein] GO:0007004 [telomere maintenance via telomerase] GO:0008180 [COP9 signalosome] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0019062 [virion attachment to host cell] GO:0019900 [kinase binding] GO:0021955 [central nervous system neuron axonogenesis] GO:0023026 [MHC class II protein complex binding] GO:0030010 [establishment of cell polarity] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0030911 [TPR domain binding] GO:0031072 [heat shock protein binding] GO:0031396 [regulation of protein ubiquitination] GO:0031625 [ubiquitin protein ligase binding] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032516 [positive regulation of phosphoprotein phosphatase activity] GO:0032991 [protein-containing complex] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0034605 [cellular response to heat] GO:0034751 [aryl hydrocarbon receptor complex] GO:0034774 [secretory granule lumen] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042277 [peptide binding] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043008 [ATP-dependent protein binding] GO:0043025 [neuronal cell body] GO:0043312 [neutrophil degranulation] GO:0044294 [dendritic growth cone] GO:0044295 [axonal growth cone] GO:0045296 [cadherin binding] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045597 [positive regulation of cell differentiation] GO:0046983 [protein dimerization activity] GO:0048156 [tau protein binding] GO:0048471 [perinuclear region of cytoplasm] GO:0048675 [axon extension] GO:0050821 [protein stabilization] GO:0051082 [unfolded protein binding] GO:0051131 [chaperone-mediated protein complex assembly] GO:0051248 [negative regulation of protein metabolic process] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051973 [positive regulation of telomerase activity] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0070182 [DNA polymerase binding] GO:0071157 [negative regulation of cell cycle arrest] GO:0097435 [supramolecular fiber organization] GO:0097718 [disordered domain specific binding] GO:1900034 [regulation of cellular response to heat] GO:1901389 [negative regulation of transforming growth factor beta activation] GO:1901799 [negative regulation of proteasomal protein catabolic process] GO:1902949 [positive regulation of tau-protein kinase activity] GO:1903827 [regulation of cellular protein localization] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904813 [ficolin-1-rich granule lumen] GO:1905323 [telomerase holoenzyme complex assembly] GO:1990226 [histone methyltransferase binding] GO:1990565 [HSP90-CDC37 chaperone complex] GO:2000010 [positive regulation of protein localization to cell surface]