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SIRT1
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  • SIRT1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

SIRT1
Synonyms SIR2L1
Gene descriptioni

Full gene name according to HGNC.

Sirtuin 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Enzymes
Metabolic proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 10
Cytoband q21.3
Chromosome location (bp) 67884656 - 67918390
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000096717 (version 103.38)
Entrez gene 23411
HGNC HGNC:14929
UniProt Q96EB6 (UniProt - Evidence at protein level)
neXtProt NX_Q96EB6
Antibodypedia SIRT1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 344

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
SIRT1-201
SIRT1-202
SIRT1-203
SIRT1-204


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
SIRT1-201
ENSP00000212015
ENST00000212015
Q96EB6 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-1 SirtT1 75 kDa fragment
A0A024QZQ1 [Target identity:100%; Query identity:100%]
Sirtuin (Silent mating type information regulation 2 homolog) 1 (S. cerevisiae), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Metabolic proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000012 [single strand break repair]
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000183 [rDNA heterochromatin assembly]
GO:0000720 [pyrimidine dimer repair by nucleotide-excision repair]
GO:0000731 [DNA synthesis involved in DNA repair]
GO:0000785 [chromatin]
GO:0000791 [euchromatin]
GO:0000792 [heterochromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001542 [ovulation from ovarian follicle]
GO:0001650 [fibrillar center]
GO:0001678 [cellular glucose homeostasis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002039 [p53 binding]
GO:0002821 [positive regulation of adaptive immune response]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005637 [nuclear inner membrane]
GO:0005654 [nucleoplasm]
GO:0005677 [chromatin silencing complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006346 [DNA methylation-dependent heterochromatin assembly]
GO:0006476 [protein deacetylation]
GO:0006642 [triglyceride mobilization]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007283 [spermatogenesis]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007517 [muscle organ development]
GO:0007569 [cell aging]
GO:0007623 [circadian rhythm]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009267 [cellular response to starvation]
GO:0010629 [negative regulation of gene expression]
GO:0010824 [regulation of centrosome duplication]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010883 [regulation of lipid storage]
GO:0010906 [regulation of glucose metabolic process]
GO:0010934 [macrophage cytokine production]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016032 [viral process]
GO:0016239 [positive regulation of macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0016575 [histone deacetylation]
GO:0016605 [PML body]
GO:0016740 [transferase activity]
GO:0017136 [NAD-dependent histone deacetylase activity]
GO:0018394 [peptidyl-lysine acetylation]
GO:0019213 [deacetylase activity]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031393 [negative regulation of prostaglandin biosynthetic process]
GO:0031507 [heterochromatin assembly]
GO:0031648 [protein destabilization]
GO:0032007 [negative regulation of TOR signaling]
GO:0032071 [regulation of endodeoxyribonuclease activity]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032868 [response to insulin]
GO:0032922 [circadian regulation of gene expression]
GO:0032991 [protein-containing complex]
GO:0033210 [leptin-mediated signaling pathway]
GO:0033553 [rDNA heterochromatin]
GO:0033558 [protein deacetylase activity]
GO:0034391 [regulation of smooth muscle cell apoptotic process]
GO:0034979 [NAD-dependent protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035098 [ESC/E(Z) complex]
GO:0035257 [nuclear hormone receptor binding]
GO:0035356 [cellular triglyceride homeostasis]
GO:0035358 [regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042326 [negative regulation of phosphorylation]
GO:0042393 [histone binding]
GO:0042542 [response to hydrogen peroxide]
GO:0042595 [behavioral response to starvation]
GO:0042632 [cholesterol homeostasis]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043398 [HLH domain binding]
GO:0043425 [bHLH transcription factor binding]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044321 [response to leptin]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0045739 [positive regulation of DNA repair]
GO:0045766 [positive regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0046969 [NAD-dependent histone deacetylase activity (H3-K9 specific)]
GO:0048511 [rhythmic process]
GO:0050872 [white fat cell differentiation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051152 [positive regulation of smooth muscle cell differentiation]
GO:0051574 [positive regulation of histone H3-K9 methylation]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0055089 [fatty acid homeostasis]
GO:0060766 [negative regulation of androgen receptor signaling pathway]
GO:0061647 [histone H3-K9 modification]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070403 [NAD+ binding]
GO:0070829 [heterochromatin maintenance]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:0070914 [UV-damage excision repair]
GO:0070932 [histone H3 deacetylation]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071441 [negative regulation of histone H3-K14 acetylation]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0071900 [regulation of protein serine/threonine kinase activity]
GO:0090335 [regulation of brown fat cell differentiation]
GO:0090400 [stress-induced premature senescence]
GO:0106230 [protein depropionylation]
GO:0106231 [protein-propionyllysine depropionylase activity]
GO:1900034 [regulation of cellular response to heat]
GO:1900113 [negative regulation of histone H3-K9 trimethylation]
GO:1901215 [negative regulation of neuron death]
GO:1901984 [negative regulation of protein acetylation]
GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1904179 [positive regulation of adipose tissue development]
GO:1990254 [keratin filament binding]
GO:1990619 [histone H3-K9 deacetylation]
GO:1990830 [cellular response to leukemia inhibitory factor]
GO:1990841 [promoter-specific chromatin binding]
GO:2000111 [positive regulation of macrophage apoptotic process]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000619 [negative regulation of histone H4-K16 acetylation]
GO:2000655 [negative regulation of cellular response to testosterone stimulus]
GO:2000757 [negative regulation of peptidyl-lysine acetylation]
GO:2000773 [negative regulation of cellular senescence]
GO:2000774 [positive regulation of cellular senescence]
Show all
747 aa
81.7 kDa
No 0
SIRT1-202
ENSP00000384063
ENST00000403579
B0QZ35 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-1; cDNA FLJ90324 fis, clone NT2RP2001817, highly similar to NAD-dependent deacetylase sirtuin-1
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001650 [fibrillar center]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
444 aa
49.2 kDa
No 0
SIRT1-203
ENSP00000384508
ENST00000406900
B0QZ35 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-1; cDNA FLJ90324 fis, clone NT2RP2001817, highly similar to NAD-dependent deacetylase sirtuin-1
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001650 [fibrillar center]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
444 aa
49.2 kDa
No 0
SIRT1-204
ENSP00000409208
ENST00000432464
E9PC49 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-1
Show all
Metabolic proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001650 [fibrillar center]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0016740 [transferase activity]
GO:0070403 [NAD+ binding]
Show all
452 aa
50.5 kDa
No 0

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  • contact@proteinatlas.org

The Project

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  • PUBLICATIONS

The Human Protein Atlas

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  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.