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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:83.7 nTPM
HPA:83.7 nTPM
GTEx:85.5 nTPM
FANTOM5:373.0 Scaled Tags Per Million
Pig:66.7 nTPM
Mouse:26.3 nTPM
Allen mouse:0.1 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 83.7
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 80.8
2666 Male, age 74, left hemisphere 86.1
1870 Female, age 42, unknown 85.2
1830 Male, age 51, unknown 81.6
1833 Male, age 53, unknown 81.3
2219 Male, age 76, both hemispheres 80.0
2828 Female, age 72, unknown 79.7
2411 Female, age 72, unknown 79.4
2019 Male, age 18, unknown 78.8
1827 Male, age 72, unknown 78.2
2586 Male, age 75, left hemisphere 78.0
Dorsal raphe nucleus
nTPM: 78.6
1828 Male, age 53, unknown 80.1
2016 Female, age 72, unknown 79.4
2750 Male, age 76, both hemispheres 78.3
2298 Female, age 72, unknown 77.8
2047 Male, age 72, unknown 77.4
Inferior colliculus
nTPM: 80.5
2849 Male, age 72, unknown 84.3
1890 Male, age 53, unknown 80.4
1848 Female, age 42, unknown 79.4
2097 Female, age 72, unknown 78.0
Median raphe nucleus
nTPM: 80.1
2220 Male, age 76, midline 80.1
Pedunculopontine tegmental nucleus
nTPM: 77.5
2334 Male, age 80, both hemispheres 80.2
2338 Male, age 61, both hemispheres 76.7
1921 Female, age 85, both hemispheres 75.7
Periaquaductal grey, anterior
nTPM: 77.9
2502 Female, age 75, unknown 81.3
1947 Male, age 18, unknown 76.7
1795 Male, age 51, unknown 75.7
Periaquaductal grey, dorsal
nTPM: 83.3
2850 Male, age 76, both hemispheres 87.7
2464 Female, age 72, unknown 83.7
1840 Male, age 53, unknown 81.5
1831 Male, age 72, unknown 80.3
Periaquaductal grey, lateral
nTPM: 77.3
2053 Male, age 18, unknown 80.0
2140 Male, age 76, both hemispheres 80.0
2272 Male, age 74, both hemispheres 72.0
Pretectal area
nTPM: 78.6
1815 Male, age 53, unknown 80.8
2825 Male, age 18, unknown 80.8
1817 Female, age 42, unknown 80.3
2007 Male, age 72, unknown 78.9
2224 Female, age 72, unknown 78.8
2316 Male, age 76, right hemisphere 78.4
1816 Male, age 51, unknown 78.2
2407 Male, age 75, both hemispheres 78.0
1944 Female, age 72, unknown 77.6
2273 Male, age 74, both hemispheres 76.5
2667 Female, age 75, unknown 76.3
Red nucleus
nTPM: 83.7
2503 Female, age 72, unknown 88.9
1821 Female, age 72, unknown 86.4
1865 Male, age 51, unknown 85.8
2725 Female, age 75, unknown 84.5
1954 Female, age 42, unknown 84.2
2769 Male, age 72, unknown 84.0
1904 Male, age 53, unknown 83.5
2227 Male, age 72, unknown 82.4
2588 Male, age 74, left hemisphere 81.8
2584 Male, age 75, left hemisphere 81.5
2823 Male, age 76, right hemisphere 81.4
2785 Male, age 18, unknown 79.8
Substantia nigra
nTPM: 78.9
2699 Male, age 18, unknown 82.6
2665 Male, age 74, both hemispheres 82.0
1889 Female, age 72, unknown 79.8
2241 Male, age 72, unknown 78.6
1941 Male, age 53, unknown 78.4
2590 Female, age 75, unknown 78.3
2409 Female, age 72, unknown 78.2
1851 Male, age 51, unknown 78.1
2583 Male, age 75, right hemisphere 77.3
1916 Female, age 42, unknown 75.4
Superior colliculus
nTPM: 80.1
1995 Male, age 72, unknown 83.9
1913 Female, age 42, unknown 83.5
2587 Male, age 74, left hemisphere 82.4
1895 Male, age 76, right hemisphere 80.5
1839 Male, age 51, unknown 80.2
2087 Female, age 72, unknown 79.1
2668 Female, age 75, unknown 78.7
1796 Male, age 53, unknown 77.8
2664 Male, age 75, both hemispheres 77.7
2261 Male, age 18, unknown 77.5
Ventral tegmental area
nTPM: 78.7
2223 Female, age 72, unknown 82.4
1942 Male, age 51, unknown 79.1
2021 Male, age 53, unknown 78.3
2410 Female, age 72, unknown 77.6
1915 Female, age 42, unknown 77.3
2218 Male, age 76, both hemispheres 77.2

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 85.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 85.5
Samples: 139

Max nTPM: 205.3
Min nTPM: 39.1
Std nTPM: 28.3
Median nTPM: 78.9
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 205.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 179.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 171.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 153.9
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 145.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 142.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 141.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 139.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 139.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 138.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 135.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 131.4
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 130.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 129.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 128.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 127.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 124.4
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 120.8
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 119.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 114.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 113.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 110.9
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 110.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 109.4
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 106.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 104.0
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 103.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 102.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 102.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 100.3
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 99.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 98.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 98.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 97.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 97.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 96.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 94.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 93.9
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 93.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 92.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 92.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 92.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 91.3
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 91.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 90.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 90.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 89.2
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 88.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 88.3
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 87.6
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 86.2
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 86.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 85.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 85.7
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 85.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 85.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 84.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 84.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 82.8
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 82.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 82.1
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 81.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 81.5
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 80.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 80.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 80.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 80.3
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 80.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 80.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 78.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 78.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 78.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 78.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 78.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 78.5
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 78.2
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 77.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 77.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 76.3
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 76.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 76.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 75.9
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 75.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 74.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 74.8
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 74.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 74.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 73.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 72.7
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 71.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 70.2
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 69.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 69.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 69.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 69.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 68.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 68.4
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 67.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 67.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 67.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 66.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 66.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 66.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 66.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 65.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 65.6
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 65.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 64.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 64.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 64.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 63.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 63.7
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 63.3
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 62.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 61.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 61.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 61.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 60.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 60.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 59.4
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 59.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 58.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 58.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 58.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 56.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 56.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 55.8
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 55.0
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 55.0
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 54.2
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 54.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 53.7
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 52.0
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 51.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 50.3
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 50.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 45.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 41.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 39.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 373.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 373.0
FF:10158-103A5 76 years, female 373.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 66.7
Pig sample Sample description nTPM
Midbrain
nTPM: 66.7
Samples: 4

Max nTPM: 100.1
Min nTPM: 47.7
Sample A Female 100.1
Sample B Female 67.3
Sample C Male 51.6
Sample D Male 47.7
Periaqueductal gray
nTPM: 62.9
Samples: 3

Max nTPM: 65.3
Min nTPM: 61.0
Sample B Female 62.3
Sample C Male 65.3
Sample D Male 61.0
Substantia nigra
nTPM: 61.2
Samples: 4

Max nTPM: 71.1
Min nTPM: 54.8
Sample A Female 57.0
Sample B Female 54.8
Sample C Male 61.7
Sample D Male 71.1
Superior colliculi
nTPM: 53.9
Samples: 4

Max nTPM: 65.1
Min nTPM: 38.6
Sample A Female 56.7
Sample B Female 38.6
Sample C Male 55.3
Sample D Male 65.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 26.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 26.3
Samples: 4

Max nTPM: 28.1
Min nTPM: 24.2
Sample A Male 26.3
Sample B Male 26.5
Sample C Female 28.1
Sample D Female 24.2

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.1
70608547 Antisense, RP_050630_01_E07, Mouse strain C57BL/6J (56 days, male) 0.1

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