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ABL1
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  • ABL1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

ABL1
Synonyms ABL, c-ABL, JTK7, p150
Gene descriptioni

Full gene name according to HGNC.

ABL proto-oncogene 1, non-receptor tyrosine kinase
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
RAS pathway related proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 9
Cytoband q34.12
Chromosome location (bp) 130713016 - 130887675
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000097007 (version 103.38)
Entrez gene 25
HGNC HGNC:76
UniProt P00519 (UniProt - Evidence at protein level)
neXtProt NX_P00519
Antibodypedia ABL1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 10      # Population variants: 601

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
ABL1-201
ABL1-202
ABL1-203


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
ABL1-201
ENSP00000323315
ENST00000318560
P00519 [Direct mapping]
Tyrosine-protein kinase ABL1
A0A024R8E2 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003785 [actin monomer binding]
GO:0004515 [nicotinate-nucleotide adenylyltransferase activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007050 [cell cycle arrest]
GO:0007155 [cell adhesion]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010506 [regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016604 [nuclear body]
GO:0016740 [transferase activity]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019905 [syntaxin binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030155 [regulation of cell adhesion]
GO:0030425 [dendrite]
GO:0030516 [regulation of axon extension]
GO:0031113 [regulation of microtubule polymerization]
GO:0031965 [nuclear membrane]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0032991 [protein-containing complex]
GO:0034599 [cellular response to oxidative stress]
GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0038191 [neuropilin binding]
GO:0042169 [SH2 domain binding]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043542 [endothelial cell migration]
GO:0045184 [establishment of protein localization]
GO:0045580 [regulation of T cell differentiation]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051882 [mitochondrial depolarization]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0070064 [proline-rich region binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071103 [DNA conformation change]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0098794 [postsynapse]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900275 [negative regulation of phospholipase C activity]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1903351 [cellular response to dopamine]
GO:1904528 [positive regulation of microtubule binding]
GO:1904531 [positive regulation of actin filament binding]
GO:1905244 [regulation of modification of synaptic structure]
GO:1990051 [activation of protein kinase C activity]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
1130 aa
122.9 kDa
No 0
ABL1-202
ENSP00000361423
ENST00000372348
P00519 [Direct mapping]
Tyrosine-protein kinase ABL1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0001784 [phosphotyrosine residue binding]
GO:0001843 [neural tube closure]
GO:0001922 [B-1 B cell homeostasis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002322 [B cell proliferation involved in immune response]
GO:0002333 [transitional one stage B cell differentiation]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0003785 [actin monomer binding]
GO:0004515 [nicotinate-nucleotide adenylyltransferase activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0006909 [phagocytosis]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007050 [cell cycle arrest]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009791 [post-embryonic development]
GO:0010506 [regulation of autophagy]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016604 [nuclear body]
GO:0016740 [transferase activity]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019904 [protein domain specific binding]
GO:0019905 [syntaxin binding]
GO:0021587 [cerebellum morphogenesis]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030035 [microspike assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030155 [regulation of cell adhesion]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030516 [regulation of axon extension]
GO:0031113 [regulation of microtubule polymerization]
GO:0031252 [cell leading edge]
GO:0031965 [nuclear membrane]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0032991 [protein-containing complex]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034599 [cellular response to oxidative stress]
GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038189 [neuropilin signaling pathway]
GO:0038191 [neuropilin binding]
GO:0042100 [B cell proliferation]
GO:0042127 [regulation of cell population proliferation]
GO:0042169 [SH2 domain binding]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042981 [regulation of apoptotic process]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043542 [endothelial cell migration]
GO:0045184 [establishment of protein localization]
GO:0045580 [regulation of T cell differentiation]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046632 [alpha-beta T cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0046875 [ephrin receptor binding]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048668 [collateral sprouting]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050798 [activated T cell proliferation]
GO:0050852 [T cell receptor signaling pathway]
GO:0050853 [B cell receptor signaling pathway]
GO:0050885 [neuromuscular process controlling balance]
GO:0051015 [actin filament binding]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0051726 [regulation of cell cycle]
GO:0051882 [mitochondrial depolarization]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060020 [Bergmann glial cell differentiation]
GO:0060563 [neuroepithelial cell differentiation]
GO:0070064 [proline-rich region binding]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071103 [DNA conformation change]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0072359 [circulatory system development]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090135 [actin filament branching]
GO:0098794 [postsynapse]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1900272 [negative regulation of long-term synaptic potentiation]
GO:1900275 [negative regulation of phospholipase C activity]
GO:1901216 [positive regulation of neuron death]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1903053 [regulation of extracellular matrix organization]
GO:1903351 [cellular response to dopamine]
GO:1904528 [positive regulation of microtubule binding]
GO:1904531 [positive regulation of actin filament binding]
GO:1905244 [regulation of modification of synaptic structure]
GO:1905555 [positive regulation blood vessel branching]
GO:1990051 [activation of protein kinase C activity]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000772 [regulation of cellular senescence]
GO:2000773 [negative regulation of cellular senescence]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
1149 aa
125 kDa
No 0
ABL1-203
ENSP00000376971
ENST00000393293
R4GRW0 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of haematopoietic and lymphoid tissues
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
64 aa
6.9 kDa
No 0

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  • PUBLICATIONS

The Human Protein Atlas

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  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.